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Discriminative stimulus properties in rats of the novel antipsychotic quetiapine.

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  • Author(s): Smith, Judith A., Liverpool U, Dept of Psychology, Liverpool, United Kingdom; Goudie, Andrew J., Liverpool U, Dept of Psychology, Liverpool, United Kingdom, Goudie, Andrew J., Liverpool U, Dept of Psychology, Liverpool, United Kingdom,
  • Source:
    Experimental and Clinical Psychopharmacology, Vol 10(4), Nov, 2002. pp. 376-384.
  • Publisher:
    US : American Psychological Association
  • Publication Type:
    Journal; Peer Reviewed Journal
  • Document Type:
    Journal Article
  • معلومة اضافية
    • Address:
      Goudie, Andrew J., Liverpool U, Dept of Psychology, Eleanor Rathbone Bldg, Bedford Street, Liverpool, United Kingdom, L69 7ZA, ajg@liverpool.ac.uk
    • Keywords:
      novel antipsychotic discrimination, novel antipsychotic generalization, atypical vs typical antipsychotics, rats
    • Abstract:
      Rats discriminated the novel antipsychotic quetiapine (Seroquel). Full generalization was seen with the novel ("atypical") antipsychotics, clozapine, olanzapine, and risperidone. Generalization was not seen with the older "typical" antipsychotics, haloperidol, chlorpromazine, and loxapine, or with the novel atypical antipsychotic, amisulpride. The pattern of generalization resembled that seen in rats trained to discriminate a low dose (1.25 mg/kg) of clozapine, which dissociates most novel antipsychotics from typical antipsychotics. However, the failure of the novel antipsychotic amisulpride to generalize demonstrates that this bioassay does not detect all novel antipsychotics. These data suggest that the discrimination of antipsychotics such as quetiapine may be of value in the development of novel antipsychotics, although the relationship between the discriminative properties of such drugs and their clinical actions is unclear. (PsycINFO Database Record (c) 2013 APA, all rights reserved) (journal abstract)
    • Subject Terms:
    • PsycINFO Classification:
      Psychopharmacology (2580)
    • Population:
      Animal
      Female
    • Methodology:
      Empirical Study
    • Physical Description:
      Print
    • Publication Date:
      Accepted: May 16, 2002; Revised: Apr 8, 2002; First Submitted: Oct 22, 2001
    • Publication Date:
      20060710
    • Copyright:
      American Psychological Association. 2002
    • Accession Number:
      http://dx.doi.org/10.1037/1064-1297.10.4.376
    • Accession Number:
      12498334
    • Accession Number:
      pha-10-4-376
    • Accession Number:
      2002-06535-009
  • Citations
    • ABNT:
      SMITH, J. A.; GOUDIE, A. J. Discriminative stimulus properties in rats of the novel antipsychotic quetiapine. Experimental and Clinical Psychopharmacology, [s. l.], v. 10, n. 4, p. 376–384, 2002. DOI 10.1037/1064-1297.10.4.376. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edspdh&AN=2002-06535-009&custid=s8280428. Acesso em: 14 ago. 2020.
    • AMA:
      Smith JA, Goudie AJ. Discriminative stimulus properties in rats of the novel antipsychotic quetiapine. Experimental and Clinical Psychopharmacology. 2002;10(4):376-384. doi:10.1037/1064-1297.10.4.376
    • APA:
      Smith, J. A., & Goudie, A. J. (2002). Discriminative stimulus properties in rats of the novel antipsychotic quetiapine. Experimental and Clinical Psychopharmacology, 10(4), 376–384. https://doi.org/10.1037/1064-1297.10.4.376
    • Chicago/Turabian: Author-Date:
      Smith, Judith A., and Andrew J. Goudie. 2002. “Discriminative Stimulus Properties in Rats of the Novel Antipsychotic Quetiapine.” Experimental and Clinical Psychopharmacology 10 (4): 376–84. doi:10.1037/1064-1297.10.4.376.
    • Harvard:
      Smith, J. A. and Goudie, A. J. (2002) ‘Discriminative stimulus properties in rats of the novel antipsychotic quetiapine’, Experimental and Clinical Psychopharmacology, 10(4), pp. 376–384. doi: 10.1037/1064-1297.10.4.376.
    • Harvard: Australian:
      Smith, JA & Goudie, AJ 2002, ‘Discriminative stimulus properties in rats of the novel antipsychotic quetiapine’, Experimental and Clinical Psychopharmacology, vol. 10, no. 4, pp. 376–384, viewed 14 August 2020, .
    • MLA:
      Smith, Judith A., and Andrew J. Goudie. “Discriminative Stimulus Properties in Rats of the Novel Antipsychotic Quetiapine.” Experimental and Clinical Psychopharmacology, vol. 10, no. 4, Nov. 2002, pp. 376–384. EBSCOhost, doi:10.1037/1064-1297.10.4.376.
    • Chicago/Turabian: Humanities:
      Smith, Judith A., and Andrew J. Goudie. “Discriminative Stimulus Properties in Rats of the Novel Antipsychotic Quetiapine.” Experimental and Clinical Psychopharmacology 10, no. 4 (November 2002): 376–84. doi:10.1037/1064-1297.10.4.376.
    • Vancouver/ICMJE:
      Smith JA, Goudie AJ. Discriminative stimulus properties in rats of the novel antipsychotic quetiapine. Experimental and Clinical Psychopharmacology [Internet]. 2002 Nov [cited 2020 Aug 14];10(4):376–84. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edspdh&AN=2002-06535-009&custid=s8280428