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Sex-Specific Protection of Osteoarthritis by Deleting Cartilage Acid Protein 1

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  • معلومة اضافية
    • Publication Information:
      Public Library of Science, 2016.
    • Publication Date:
      2016
    • Collection:
      HMS Scholarly Articles
    • Abstract:
      Cartilage acidic protein 1 (CRTAC1) was recently identified as an elevated protein in the synovial fluid of patients with osteoarthritis (OA) by a proteomic analysis. This gene is also upregulated in both human and mouse OA by transcriptomic analysis. The objective of this study was to characterize the expression and function of CRTAC1 in OA. Here, we first confirm the increase of CRTAC1 in cartilage biopsies from OA patients undergoing joint replacement by real-time PCR and immunohistochemistry. Furthermore, we report that proinflammatory cytokines interleukin-1beta and tumor necrosis factor alpha upregulate CRTAC1 expression in primary human articular chondrocytes and synovial fibroblasts. Genetic deletion of Crtac1 in mice significantly inhibited cartilage degradation, osteophyte formation and gait abnormalities of post-traumatic OA in female, but not male, animals undergoing the destabilization of medial meniscus (DMM) surgery. Taken together, CRTAC1 is upregulated in the osteoarthritic joint and directly induced in chondrocytes and synovial fibroblasts by pro-inflammatory cytokines. This molecule is necessary for the progression of OA in female mice after DMM surgery and thus represents a potential therapy for this prevalent disease, especially for women who demonstrate higher rates and more severe OA.
    • ISSN:
      1932-6203
    • Relation:
      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945026/pdf/; PLoS ONE
    • Accession Number:
      10.1371/journal.pone.0159157
    • Rights:
      open
      URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
    • Accession Number:
      edshld.1.29002583
  • Citations
    • ABNT:
      GE, X. et al. Sex-Specific Protection of Osteoarthritis by Deleting Cartilage Acid Protein 1. [s. l.], 2016. DOI 10.1371/journal.pone.0159157. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edshld&AN=edshld.1.29002583&custid=s8280428. Acesso em: 15 ago. 2020.
    • AMA:
      Ge X, Ritter SY, Tsang K, Shi R, Takei K, Aliprantis AO. Sex-Specific Protection of Osteoarthritis by Deleting Cartilage Acid Protein 1. 2016. doi:10.1371/journal.pone.0159157
    • APA:
      Ge, X., Ritter, S. Y., Tsang, K., Shi, R., Takei, K., & Aliprantis, A. O. (2016). Sex-Specific Protection of Osteoarthritis by Deleting Cartilage Acid Protein 1. https://doi.org/10.1371/journal.pone.0159157
    • Chicago/Turabian: Author-Date:
      Ge, Xianpeng, Susan Y. Ritter, Kelly Tsang, Ruirui Shi, Kohtaro Takei, and Antonios O. Aliprantis. 2016. “Sex-Specific Protection of Osteoarthritis by Deleting Cartilage Acid Protein 1.” doi:10.1371/journal.pone.0159157.
    • Harvard:
      Ge, X. et al. (2016) ‘Sex-Specific Protection of Osteoarthritis by Deleting Cartilage Acid Protein 1’. doi: 10.1371/journal.pone.0159157.
    • Harvard: Australian:
      Ge, X, Ritter, SY, Tsang, K, Shi, R, Takei, K & Aliprantis, AO 2016, ‘Sex-Specific Protection of Osteoarthritis by Deleting Cartilage Acid Protein 1’, viewed 15 August 2020, .
    • MLA:
      Ge, Xianpeng, et al. Sex-Specific Protection of Osteoarthritis by Deleting Cartilage Acid Protein 1. 2016. EBSCOhost, doi:10.1371/journal.pone.0159157.
    • Chicago/Turabian: Humanities:
      Ge, Xianpeng, Susan Y. Ritter, Kelly Tsang, Ruirui Shi, Kohtaro Takei, and Antonios O. Aliprantis. “Sex-Specific Protection of Osteoarthritis by Deleting Cartilage Acid Protein 1,” 2016. doi:10.1371/journal.pone.0159157.
    • Vancouver/ICMJE:
      Ge X, Ritter SY, Tsang K, Shi R, Takei K, Aliprantis AO. Sex-Specific Protection of Osteoarthritis by Deleting Cartilage Acid Protein 1. 2016 [cited 2020 Aug 15]; Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edshld&AN=edshld.1.29002583&custid=s8280428