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Clinical evaluation of pimecrolimus eye drops for treatment of canine keratoconjunctivitis sicca: A comparison with cyclosporine A

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  • معلومة اضافية
    • Affiliation:
      a Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot 76100, Israel
      b Novartis Institutes for BioMedical Research, Basel 4002, Switzerland
      c Faculty of Medicine, University of Strasbourg, Strasbourg 67085, France
      d Veterinary Ophthalmology Clinic, Berlin 14163, Germany
      e Veterinary Ophthalmology Clinic, Chemnitz 09127, Germany
      f School of Veterinary Medicine, Autonomous University of Barcelona, Bellaterra 08193, Spain
      g Vetsuisse Faculty, University of Zurich, Zurich 8057, Switzerland
    • Keywords:
      Dog
      Keratoconjunctivitis sicca
      Dry eye
      Cyclosporine A
      Pimecrolimus
    • Abstract:
      The aim of this study was to evaluate the efficacy of pimecrolimus oil-based eye drops in alleviating the clinical signs of keratoconjunctivitis sicca (KCS) in dogs and to compare the efficacy with that of cyclosporine A (CsA) ointment. An open-label, multicenter study enrolling 44 dogs previously untreated with CsA was conducted. Dogs were randomly assigned to a treatment group and medicated twice daily for 8 weeks. After that time the mean increase (±SEM) in the Schirmer tear test was 9.2 ± 1.6 mm/min in the pimecrolimus group and 5.8 ± 1.1 mm/min in the CsA group ( P = 0.085). The improvement in clinical signs of inflammation in eyes treated with pimecrolimus was significantly greater than in eyes treated with CsA ( P = 0.02). The results show that 1% pimecrolimus oily eye drops are as safe as and more effective than CsA ointment in controlling KCS in dogs.
    • ISSN:
      1090-0233
    • Accession Number:
      10.1016/j.tvjl.2007.08.034
    • Accession Number:
      S1090023307003024
    • Copyright:
      Copyright @ 2007 Elsevier Ltd All rights reserved.
  • Citations
    • ABNT:
      OFRI, R. et al. Clinical evaluation of pimecrolimus eye drops for treatment of canine keratoconjunctivitis sicca: A comparison with cyclosporine A. The Veterinary Journal, [s. l.], v. 179, n. 1, p. 70–77, 2009. DOI 10.1016/j.tvjl.2007.08.034. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edselp&AN=S1090023307003024&custid=s8280428. Acesso em: 1 abr. 2020.
    • AMA:
      Ofri R, Lambrou GN, Allgoewer I, et al. Clinical evaluation of pimecrolimus eye drops for treatment of canine keratoconjunctivitis sicca: A comparison with cyclosporine A. The Veterinary Journal. 2009;179(1):70-77. doi:10.1016/j.tvjl.2007.08.034.
    • APA:
      Ofri, R., Lambrou, G. N., Allgoewer, I., Graenitz, U., Pena, T. M., Spiess, B. M., & Latour, E. (2009). Clinical evaluation of pimecrolimus eye drops for treatment of canine keratoconjunctivitis sicca: A comparison with cyclosporine A. The Veterinary Journal, 179(1), 70–77. https://doi.org/10.1016/j.tvjl.2007.08.034
    • Chicago/Turabian: Author-Date:
      Ofri, Ron, George N. Lambrou, Ingrid Allgoewer, Uwe Graenitz, Teresa M. Pena, Bernhard M. Spiess, and Elisabeth Latour. 2009. “Clinical Evaluation of Pimecrolimus Eye Drops for Treatment of Canine Keratoconjunctivitis Sicca: A Comparison with Cyclosporine A.” The Veterinary Journal 179 (1): 70–77. doi:10.1016/j.tvjl.2007.08.034.
    • Harvard:
      Ofri, R. et al. (2009) ‘Clinical evaluation of pimecrolimus eye drops for treatment of canine keratoconjunctivitis sicca: A comparison with cyclosporine A’, The Veterinary Journal, 179(1), pp. 70–77. doi: 10.1016/j.tvjl.2007.08.034.
    • Harvard: Australian:
      Ofri, R, Lambrou, GN, Allgoewer, I, Graenitz, U, Pena, TM, Spiess, BM & Latour, E 2009, ‘Clinical evaluation of pimecrolimus eye drops for treatment of canine keratoconjunctivitis sicca: A comparison with cyclosporine A’, The Veterinary Journal, vol. 179, no. 1, pp. 70–77, viewed 1 April 2020, .
    • MLA:
      Ofri, Ron, et al. “Clinical Evaluation of Pimecrolimus Eye Drops for Treatment of Canine Keratoconjunctivitis Sicca: A Comparison with Cyclosporine A.” The Veterinary Journal, vol. 179, no. 1, Jan. 2009, pp. 70–77. EBSCOhost, doi:10.1016/j.tvjl.2007.08.034.
    • Chicago/Turabian: Humanities:
      Ofri, Ron, George N. Lambrou, Ingrid Allgoewer, Uwe Graenitz, Teresa M. Pena, Bernhard M. Spiess, and Elisabeth Latour. “Clinical Evaluation of Pimecrolimus Eye Drops for Treatment of Canine Keratoconjunctivitis Sicca: A Comparison with Cyclosporine A.” The Veterinary Journal 179, no. 1 (January 1, 2009): 70–77. doi:10.1016/j.tvjl.2007.08.034.
    • Vancouver/ICMJE:
      Ofri R, Lambrou GN, Allgoewer I, Graenitz U, Pena TM, Spiess BM, et al. Clinical evaluation of pimecrolimus eye drops for treatment of canine keratoconjunctivitis sicca: A comparison with cyclosporine A. The Veterinary Journal [Internet]. 2009 Jan 1 [cited 2020 Apr 1];179(1):70–7. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edselp&AN=S1090023307003024&custid=s8280428