Expression of liver fatty acid binding protein in hepatocellular carcinoma

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  • معلومة اضافية
    • Affiliation:
      Department of Pathology, University of California, San Francisco, CA 94143
    • Note:
      Disclosures: The authors have no conflict of interest to declare.
    • Keywords:
      Liver fatty acid binding protein
      Hepatocellular carcinoma
      Hepatocellular adenoma
      HNF1A
      Well differentiated hepatocellular neoplasm
    • Abstract:
      Summary Loss of expression of liver fatty acid binding protein (LFABP) by immunohistochemistry has been shown to be characteristic of a subset of hepatocellular adenomas (HCAs) in which HNF1A is inactivated. Transformation to hepatocellular carcinoma is thought to be a very rare phenomenon in the HNF1A-inactivated variant of HCA. However, we recently observed 2 cases at our institution, 1 definite hepatocellular carcinoma and 1 possible hepatocellular carcinoma, with loss of LFABP staining, raising the possibility that LFABP down-regulation may be associated with hepatocellular carcinogenesis. Our aim was to evaluate hepatocellular carcinomas arising in various backgrounds and with varying degrees of differentiation for loss of LFABP staining. Twenty total cases of hepatocellular carcinoma were examined. Thirteen cases arose in a background of cirrhosis due to hepatitis C (n = 8) or steatohepatitis (n = 5); 7 cases arose in a noncirrhotic background, with 2 cases arising within HNF1A-inactivated variant HCA and 2 cases arising within inflammatory variant HCA. Complete loss of expression of LFABP was seen in 6 of 20 cases, including 2 cases of hepatocellular carcinoma arising within HNF1A-inactivated variant HCA. Thus, loss of staining for LFABP appears to be common in hepatocellular carcinoma and may be seen in well-differentiated hepatocellular carcinoma. Therefore, LFABP loss should not be interpreted as evidence for hepatocellular adenoma over carcinoma, when other features support a diagnosis of hepatocellular carcinoma. The findings raise consideration for a role of HNF1A inactivation in hepatocellular carcinogenesis, particularly in less differentiated tumors.
    • ISSN:
      0046-8177
    • Accession Number:
      10.1016/j.humpath.2015.12.002
    • Accession Number:
      S0046817715004852
    • Copyright:
      Copyright © 2015 Elsevier Inc. All rights reserved.
  • Citations
    • ABNT:
      CHO, S.-J.; FERRELL, L. D.; GILL, R. M. Expression of liver fatty acid binding protein in hepatocellular carcinoma. Human Pathology, [s. l.], v. 50, p. 135–139, 2016. Disponível em: . Acesso em: 21 nov. 2019.
    • AMA:
      Cho S-J, Ferrell LD, Gill RM. Expression of liver fatty acid binding protein in hepatocellular carcinoma. Human Pathology. 2016;50:135-139. doi:10.1016/j.humpath.2015.12.002.
    • APA:
      Cho, S.-J., Ferrell, L. D., & Gill, R. M. (2016). Expression of liver fatty acid binding protein in hepatocellular carcinoma. Human Pathology, 50, 135–139. https://doi.org/10.1016/j.humpath.2015.12.002
    • Chicago/Turabian: Author-Date:
      Cho, Soo-Jin, Linda D. Ferrell, and Ryan M. Gill. 2016. “Expression of Liver Fatty Acid Binding Protein in Hepatocellular Carcinoma.” Human Pathology 50 (April): 135–39. doi:10.1016/j.humpath.2015.12.002.
    • Harvard:
      Cho, S.-J., Ferrell, L. D. and Gill, R. M. (2016) ‘Expression of liver fatty acid binding protein in hepatocellular carcinoma’, Human Pathology, 50, pp. 135–139. doi: 10.1016/j.humpath.2015.12.002.
    • Harvard: Australian:
      Cho, S-J, Ferrell, LD & Gill, RM 2016, ‘Expression of liver fatty acid binding protein in hepatocellular carcinoma’, Human Pathology, vol. 50, pp. 135–139, viewed 21 November 2019, .
    • MLA:
      Cho, Soo-Jin, et al. “Expression of Liver Fatty Acid Binding Protein in Hepatocellular Carcinoma.” Human Pathology, vol. 50, Apr. 2016, pp. 135–139. EBSCOhost, doi:10.1016/j.humpath.2015.12.002.
    • Chicago/Turabian: Humanities:
      Cho, Soo-Jin, Linda D. Ferrell, and Ryan M. Gill. “Expression of Liver Fatty Acid Binding Protein in Hepatocellular Carcinoma.” Human Pathology 50 (April 1, 2016): 135–39. doi:10.1016/j.humpath.2015.12.002.
    • Vancouver/ICMJE:
      Cho S-J, Ferrell LD, Gill RM. Expression of liver fatty acid binding protein in hepatocellular carcinoma. Human Pathology [Internet]. 2016 Apr 1 [cited 2019 Nov 21];50:135–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edselp&AN=S0046817715004852&custid=s8280428