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Deep brain stimulation in Parkinson's disease: A multicentric, long-term, observational pilot study

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  • معلومة اضافية
    • Affiliation:
      a “Aldo Ravelli” Center for Neurotechnology and Experimental Brain Therapeutics, University of Milan and Fondazione IRCCS Ca' Granda - Ospedale Maggiore, Milan, Italy
      b Department of Neuroscience, Istituto di Ricerche Farmacologiche “Mario Negri IRCCS, Milan, Italy
      c Department of Neuroscience, University of Turin, Italy
      d Department of Neuroscience (DNS), University of Padua, Italy
      e Movement Disorder Unit, Department of Clinical Neurosciences, IRCCS Carlo Besta Neurological Institute, Milan, Italy
      f Department of Neurology, “F. Miulli” General Hospital, Acquaviva delle Fonti, Italy
      g Department of Neurology, Parkinson's Center, IRCCS Neuromed, Pozzilli, Italy
      h Parkinson Unit, IRCCS San Camillo Hospital, Venice, Italy
      i Department of Engineering and Architecture, University of Trieste, Trieste, Italy
      j Parkinson and movement disorders Unit, IRCCS Mondino Foundation, Pavia, Italy
      k Department of Neurology, Villa Margherita, Private clinic, Arcugnano, Vicenza, Italy
      l Department of Health Sciences, University of Milan, San Paolo Hospital, Milan, Italy
    • Keywords:
      Dementia
      Deep brain stimulation
      Falls
      Parkinson's disease
      Urinary symptoms
      Non-motor symptoms
    • Abstract:
      Background The impact of deep brain stimulation (DBS) on cognitive and urinary disorders, falls, and eventually hospitalizations and mortality in Parkinson's disease (PD) is still debated.
    • Abstract:
      Methods We conducted a retrospective pilot study in six Italian DBS centers. 91 PD patients receiving DBS and 91 age- and gender-matched controls receiving the best medical treatment alone with a minimum follow-up of one year were enrolled. Clinical data were collected from baseline to the last follow-up visit using an ad-hoc developed web-based system.
    • Abstract:
      Results The risk of dementia was similar in the two groups while patients in the surgical cohort had lower rates of MCI, urinary incontinence, nocturia, and falls. In contrast, the risk of hospital admissions related to PD was higher in the surgical cohort. However, when excluding hospitalizations related to DBS surgery, the difference between the two cohorts was not significant. The surgical cohort had a lower number of hospitalizations not related to PD. The risk of death was similar in the two groups.
    • Abstract:
      Conclusion Despite a higher risk of hospitalization, patients receiving DBS had a lower rate of MCI, urinary incontinence, nocturia and falls, without evidence of an increased risk of dementia and mortality. Although these findings need to be confirmed in prospective studies, they seem to suggest that DBS may play a significant role in the management of non-motor symptoms and common complications of advanced PD.
    • Abstract:
      @@@@Highlights •The impact of DBS on advanced Parkinson's disease complications is still debated.•The rate of MCI, urinary symptoms and falls is lower in the surgical cohort.•DBS does not increase the risk of dementia and mortality.•DBS may improve the management of non-motor symptoms of Parkinson's disease.•DBS increases the risk of hospitalizations compared to the best medical treatment.
    • ISSN:
      0022-510X
    • Accession Number:
      10.1016/j.jns.2019.07.029
    • Accession Number:
      S0022510X19303326
    • Copyright:
      © 2019 Published by Elsevier B.V.
  • Citations
    • ABNT:
      SCELZO, E. et al. Deep brain stimulation in Parkinson’s disease: A multicentric, long-term, observational pilot study. Journal of the Neurological Sciences, [s. l.], v. 405, 2019. DOI 10.1016/j.jns.2019.07.029. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edselp&AN=S0022510X19303326&custid=s8280428. Acesso em: 30 mar. 2020.
    • AMA:
      Scelzo E, Beghi E, Rosa M, et al. Deep brain stimulation in Parkinson’s disease: A multicentric, long-term, observational pilot study. Journal of the Neurological Sciences. 2019;405. doi:10.1016/j.jns.2019.07.029.
    • APA:
      Scelzo, E., Beghi, E., Rosa, M., Angrisano, S., Antonini, A., Bagella, C., Bianchi, E., Caputo, E., Lena, F., Lopiano, L., Marcante, A., Marceglia, S., Massaro, F., Modugno, N., Pacchetti, C., Pilleri, M., Pozzi, N. G., Romito, L. M., Santilli, M., … Priori, A. (2019). Deep brain stimulation in Parkinson’s disease: A multicentric, long-term, observational pilot study. Journal of the Neurological Sciences, 405. https://doi.org/10.1016/j.jns.2019.07.029
    • Chicago/Turabian: Author-Date:
      Scelzo, Emma, Ettore Beghi, Manuela Rosa, Serena Angrisano, Angelo Antonini, Caterina Bagella, Elisa Bianchi, et al. 2019. “Deep Brain Stimulation in Parkinson’s Disease: A Multicentric, Long-Term, Observational Pilot Study.” Journal of the Neurological Sciences 405 (October). doi:10.1016/j.jns.2019.07.029.
    • Harvard:
      Scelzo, E. et al. (2019) ‘Deep brain stimulation in Parkinson’s disease: A multicentric, long-term, observational pilot study’, Journal of the Neurological Sciences, 405. doi: 10.1016/j.jns.2019.07.029.
    • Harvard: Australian:
      Scelzo, E, Beghi, E, Rosa, M, Angrisano, S, Antonini, A, Bagella, C, Bianchi, E, Caputo, E, Lena, F, Lopiano, L, Marcante, A, Marceglia, S, Massaro, F, Modugno, N, Pacchetti, C, Pilleri, M, Pozzi, NG, Romito, LM, Santilli, M, Tamma, F, Weis, L, Zibetti, M & Priori, A 2019, ‘Deep brain stimulation in Parkinson’s disease: A multicentric, long-term, observational pilot study’, Journal of the Neurological Sciences, vol. 405, viewed 30 March 2020, .
    • MLA:
      Scelzo, Emma, et al. “Deep Brain Stimulation in Parkinson’s Disease: A Multicentric, Long-Term, Observational Pilot Study.” Journal of the Neurological Sciences, vol. 405, Oct. 2019. EBSCOhost, doi:10.1016/j.jns.2019.07.029.
    • Chicago/Turabian: Humanities:
      Scelzo, Emma, Ettore Beghi, Manuela Rosa, Serena Angrisano, Angelo Antonini, Caterina Bagella, Elisa Bianchi, et al. “Deep Brain Stimulation in Parkinson’s Disease: A Multicentric, Long-Term, Observational Pilot Study.” Journal of the Neurological Sciences 405 (October 15, 2019). doi:10.1016/j.jns.2019.07.029.
    • Vancouver/ICMJE:
      Scelzo E, Beghi E, Rosa M, Angrisano S, Antonini A, Bagella C, et al. Deep brain stimulation in Parkinson’s disease: A multicentric, long-term, observational pilot study. Journal of the Neurological Sciences [Internet]. 2019 Oct 15 [cited 2020 Mar 30];405. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edselp&AN=S0022510X19303326&custid=s8280428