Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Platelet indices significantly correlate with liver fibrosis in HCV-infected patients.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • معلومة اضافية
    • Publication Information:
      Public Library of Science (PLoS), 2020.
    • Publication Date:
      2020
    • Collection:
      LCC:Medicine
      LCC:Science
    • Abstract:
      AIM:A total of 241 patients with chronic HCV infection were recruited to investigate the association between liver fibrosis and PLT counts, as well as with MPV, PDW and P-LCR indices. METHODS:The determination of PLT indices was carried out using a Sysmex XT-1800i automated hematology analyzer. Serological tests for HA, LN, C-IV and PIIINP were performed in 210 patients. The liver stiffness was measured in 69 patients by transient elastography (FibroScan). RESULTS:The analysis showed that the four serum fibrosis markers were negatively correlated with PLT counts, but positively correlated with the MPV, PDW and P-LCR values. Moreover, a similar pattern was found after analyzing the FibroScan measurements, which were negatively correlated with PLT counts, but positively correlated with MPV, PDW and P-LCR values. We subdivided the HCV-infected patients into mild and advanced fibrosis groups. The PLT counts were significantly decreased and the MPV, PDW and P-LCR values were significantly increased in the advanced fibrosis group when compared with the mild fibrosis group. CONCLUSIONS:Our results demonstrate that not only the PLT counts but also the MPV, PDW and P-LCR indices significantly correlate with liver fibrosis in HCV-infected patients. Therefore, these indices may be useful laboratory measures for evaluating liver fibrosis progression.
    • File Description:
      electronic resource
    • ISSN:
      1932-6203
    • Relation:
      https://doaj.org/toc/1932-6203
    • Accession Number:
      10.1371/journal.pone.0227544
    • Rights:
      Journal Licence: CC BY
    • Accession Number:
      edsdoj.8fe7be60feac4ca7b89e082ffc6bf715
  • Citations
    • ABNT:
      LIN-NAN SHAO et al. Platelet indices significantly correlate with liver fibrosis in HCV-infected patients. PLoS ONE, [s. l.], n. 1, p. e0227544, 2020. DOI 10.1371/journal.pone.0227544. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsdoj&AN=edsdoj.8fe7be60feac4ca7b89e082ffc6bf715&custid=s8280428. Acesso em: 27 fev. 2020.
    • AMA:
      Lin-Nan Shao, Shu-Ting Zhang, Ni Wang, et al. Platelet indices significantly correlate with liver fibrosis in HCV-infected patients. PLoS ONE. 2020;(1):e0227544. doi:10.1371/journal.pone.0227544.
    • APA:
      Lin-Nan Shao, Shu-Ting Zhang, Ni Wang, Wei-Jian Yu, Mei Chen, Nan Xiao, Ying Duan, Ling-Zi Pan, Wen-Qian Song, Yue-Xin Xia, Li Zhang, Ning Qi, Ming Liu, & Shi-Hang Zhou. (2020). Platelet indices significantly correlate with liver fibrosis in HCV-infected patients. PLoS ONE, 1, e0227544. https://doi.org/10.1371/journal.pone.0227544
    • Chicago/Turabian: Author-Date:
      Lin-Nan Shao, Shu-Ting Zhang, Ni Wang, Wei-Jian Yu, Mei Chen, Nan Xiao, Ying Duan, et al. 2020. “Platelet Indices Significantly Correlate with Liver Fibrosis in HCV-Infected Patients.” PLoS ONE, no. 1: e0227544. doi:10.1371/journal.pone.0227544.
    • Harvard:
      Lin-Nan Shao et al. (2020) ‘Platelet indices significantly correlate with liver fibrosis in HCV-infected patients’, PLoS ONE, (1), p. e0227544. doi: 10.1371/journal.pone.0227544.
    • Harvard: Australian:
      Lin-Nan Shao, Shu-Ting Zhang, Ni Wang, Wei-Jian Yu, Mei Chen, Nan Xiao, Ying Duan, Ling-Zi Pan, Wen-Qian Song, Yue-Xin Xia, Li Zhang, Ning Qi, Ming Liu & Shi-Hang Zhou 2020, ‘Platelet indices significantly correlate with liver fibrosis in HCV-infected patients’, PLoS ONE, no. 1, p. e0227544, viewed 27 February 2020, .
    • MLA:
      Lin-Nan Shao, et al. “Platelet Indices Significantly Correlate with Liver Fibrosis in HCV-Infected Patients.” PLoS ONE, no. 1, 2020, p. e0227544. EBSCOhost, doi:10.1371/journal.pone.0227544.
    • Chicago/Turabian: Humanities:
      Lin-Nan Shao, Shu-Ting Zhang, Ni Wang, Wei-Jian Yu, Mei Chen, Nan Xiao, Ying Duan, et al. “Platelet Indices Significantly Correlate with Liver Fibrosis in HCV-Infected Patients.” PLoS ONE, no. 1 (2020): e0227544. doi:10.1371/journal.pone.0227544.
    • Vancouver/ICMJE:
      Lin-Nan Shao, Shu-Ting Zhang, Ni Wang, Wei-Jian Yu, Mei Chen, Nan Xiao, et al. Platelet indices significantly correlate with liver fibrosis in HCV-infected patients. PLoS ONE [Internet]. 2020 [cited 2020 Feb 27];(1):e0227544. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsdoj&AN=edsdoj.8fe7be60feac4ca7b89e082ffc6bf715&custid=s8280428