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Invariant Natural Killer T Cells

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  • معلومة اضافية
    • Publication Information:
      MDPI AG, 2013.
    • Publication Date:
      2013
    • Collection:
      LCC:Immunologic diseases. Allergy
    • Abstract:
      Invariant Natural killer T cell (iNKT cells) are a subset of T cells, which are narrowly defined as a T cell lineage expressing a semi-invariant CD1d-restricted T cell Receptors (TCRs) composed by Vα24-Jα18/Vβ11 in human, and Vα14-Jα18/Vβ8,Vβ7, and Vβ2 in mouse. Unlike conventional T cells which recognize peptides bound to highly polymorphic major histocompatibility complex (MHC) class I and II molecules, iNKT cells recognize lipid antigens, such as glycolipids, presented by CD1d, a non-polymorphic non-classical MHC class I molecule. Lipids derived from microbes, tumors, and allergens, as well as self lipids have been shown to be able to activate iNKT cells. Early on, in an immune response, ligation of the iNKT cell TCR leads to rapid and copious secretion of prototypical Th1 and Th2 cytokines. Moreover, like NK cells, iNKT cells express cytotoxic granules, such as perforin and granzyme that polarize upon activation of TCR and are able to kill target cells. Therefore iNKT cells are a very interesting subset of T cells that may bridge the innate and adaptive immune systems. Indeed, iNKT cells can mount specific responses to antigen with cytokine production and cytotoxic activity, however, their TCR evolved to recognize different glycolipid antigens in a conserved manner and to perform innate-like rather than adaptive functions. iNKT cells are now recognized as important players in atopic, autoimmune, infectious diseases, and cancer.
    • File Description:
      electronic resource
    • ISSN:
      2073-4468
    • Relation:
      http://www.mdpi.com/2073-4468/3/1/16; https://doaj.org/toc/2073-4468
    • Accession Number:
      10.3390/antib3010016
    • Rights:
      Journal Licence: CC BY
    • Accession Number:
      edsdoj.86c9ce256b9143228ccb0ed5d5926695
  • Citations
    • ABNT:
      ANTONELLA CIANFERONI. Invariant Natural Killer T Cells. Antibodies, [s. l.], v. 3, n. 1, p. 16–36, 2013. DOI 10.3390/antib3010016. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsdoj&AN=edsdoj.86c9ce256b9143228ccb0ed5d5926695&custid=s8280428. Acesso em: 12 ago. 2020.
    • AMA:
      Antonella Cianferoni. Invariant Natural Killer T Cells. Antibodies. 2013;3(1):16-36. doi:10.3390/antib3010016
    • APA:
      Antonella Cianferoni. (2013). Invariant Natural Killer T Cells. Antibodies, 3(1), 16–36. https://doi.org/10.3390/antib3010016
    • Chicago/Turabian: Author-Date:
      Antonella Cianferoni. 2013. “Invariant Natural Killer T Cells.” Antibodies 3 (1): 16–36. doi:10.3390/antib3010016.
    • Harvard:
      Antonella Cianferoni (2013) ‘Invariant Natural Killer T Cells’, Antibodies, 3(1), pp. 16–36. doi: 10.3390/antib3010016.
    • Harvard: Australian:
      Antonella Cianferoni 2013, ‘Invariant Natural Killer T Cells’, Antibodies, vol. 3, no. 1, pp. 16–36, viewed 12 August 2020, .
    • MLA:
      Antonella Cianferoni. “Invariant Natural Killer T Cells.” Antibodies, vol. 3, no. 1, Dec. 2013, pp. 16–36. EBSCOhost, doi:10.3390/antib3010016.
    • Chicago/Turabian: Humanities:
      Antonella Cianferoni. “Invariant Natural Killer T Cells.” Antibodies 3, no. 1 (December 1, 2013): 16–36. doi:10.3390/antib3010016.
    • Vancouver/ICMJE:
      Antonella Cianferoni. Invariant Natural Killer T Cells. Antibodies [Internet]. 2013 Dec 1 [cited 2020 Aug 12];3(1):16–36. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsdoj&AN=edsdoj.86c9ce256b9143228ccb0ed5d5926695&custid=s8280428