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Does Isoniazid Preventive Therapy Provide Better Treatment Outcomes in HIV-Infected Individuals in Northern Ethiopia? A Retrospective Cohort Study

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  • معلومة اضافية
    • Publication Information:
      Hindawi Limited, 2020.
    • Publication Date:
      2020
    • Collection:
      LCC:Immunologic diseases. Allergy
    • Abstract:
      Objectives. Early antiretroviral therapy (ART), isoniazid preventive therapy (IPT), and isoniazid-rifapentine (3HP) are effective strategies for preventing tuberculosis (TB) among people living with HIV (PLHIV). The study aimed to determine the effect of IPT on the TB incidence, follow-up CD4+ T cells, and all-cause mortality rate. Participants. Eligible patients on ART (n = 1, 863) were categorized into one-to-two ratios of exposed groups to IPT (n = 621) and nonexposed groups to IPT (n = 1, 242). Exposed groups entered the cohort at their first prescription of IPT, and unexposed groups entered into the study at the first prescription of ART and then followed until the occurrence of the outcome or date of administrative censoring (June 30, 2017). The outcome endpoints were TB incidence, follow-up CD4+ T cells, and all-cause mortality rate. Results. The follow-up CD4+ T cells for the exposed and nonexposed groups were 405.74 and 366.95 cells/mm (World Health Organization (WHO), 2017), respectively, a statistically significant finding (t1861 = −3.770, p
    • File Description:
      electronic resource
    • ISSN:
      2090-1240
      2090-1259
    • Relation:
      https://doaj.org/toc/2090-1240; https://doaj.org/toc/2090-1259
    • Accession Number:
      10.1155/2020/7025738
    • Rights:
      Journal Licence: CC BY
    • Accession Number:
      edsdoj.810e6dd53c344779975403fe7a1e596e
  • Citations
    • ABNT:
      TESFAY MEHARI ATEY et al. Does Isoniazid Preventive Therapy Provide Better Treatment Outcomes in HIV-Infected Individuals in Northern Ethiopia? A Retrospective Cohort Study. AIDS Research and Treatment, [s. l.], v. 2020, 2020. DOI 10.1155/2020/7025738. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsdoj&AN=edsdoj.810e6dd53c344779975403fe7a1e596e&custid=s8280428. Acesso em: 25 maio. 2020.
    • AMA:
      Tesfay Mehari Atey, Helen Bitew, Solomon Weldegebreal Asgedom, Asrat Endrias, Derbew Fikadu Berhe. Does Isoniazid Preventive Therapy Provide Better Treatment Outcomes in HIV-Infected Individuals in Northern Ethiopia? A Retrospective Cohort Study. AIDS Research and Treatment. 2020;2020. doi:10.1155/2020/7025738.
    • APA:
      Tesfay Mehari Atey, Helen Bitew, Solomon Weldegebreal Asgedom, Asrat Endrias, & Derbew Fikadu Berhe. (2020). Does Isoniazid Preventive Therapy Provide Better Treatment Outcomes in HIV-Infected Individuals in Northern Ethiopia? A Retrospective Cohort Study. AIDS Research and Treatment, 2020. https://doi.org/10.1155/2020/7025738
    • Chicago/Turabian: Author-Date:
      Tesfay Mehari Atey, Helen Bitew, Solomon Weldegebreal Asgedom, Asrat Endrias, and Derbew Fikadu Berhe. 2020. “Does Isoniazid Preventive Therapy Provide Better Treatment Outcomes in HIV-Infected Individuals in Northern Ethiopia? A Retrospective Cohort Study.” AIDS Research and Treatment 2020 (January). doi:10.1155/2020/7025738.
    • Harvard:
      Tesfay Mehari Atey et al. (2020) ‘Does Isoniazid Preventive Therapy Provide Better Treatment Outcomes in HIV-Infected Individuals in Northern Ethiopia? A Retrospective Cohort Study’, AIDS Research and Treatment, 2020. doi: 10.1155/2020/7025738.
    • Harvard: Australian:
      Tesfay Mehari Atey, Helen Bitew, Solomon Weldegebreal Asgedom, Asrat Endrias & Derbew Fikadu Berhe 2020, ‘Does Isoniazid Preventive Therapy Provide Better Treatment Outcomes in HIV-Infected Individuals in Northern Ethiopia? A Retrospective Cohort Study’, AIDS Research and Treatment, vol. 2020, viewed 25 May 2020, .
    • MLA:
      Tesfay Mehari Atey, et al. “Does Isoniazid Preventive Therapy Provide Better Treatment Outcomes in HIV-Infected Individuals in Northern Ethiopia? A Retrospective Cohort Study.” AIDS Research and Treatment, vol. 2020, Jan. 2020. EBSCOhost, doi:10.1155/2020/7025738.
    • Chicago/Turabian: Humanities:
      Tesfay Mehari Atey, Helen Bitew, Solomon Weldegebreal Asgedom, Asrat Endrias, and Derbew Fikadu Berhe. “Does Isoniazid Preventive Therapy Provide Better Treatment Outcomes in HIV-Infected Individuals in Northern Ethiopia? A Retrospective Cohort Study.” AIDS Research and Treatment 2020 (January 1, 2020). doi:10.1155/2020/7025738.
    • Vancouver/ICMJE:
      Tesfay Mehari Atey, Helen Bitew, Solomon Weldegebreal Asgedom, Asrat Endrias, Derbew Fikadu Berhe. Does Isoniazid Preventive Therapy Provide Better Treatment Outcomes in HIV-Infected Individuals in Northern Ethiopia? A Retrospective Cohort Study. AIDS Research and Treatment [Internet]. 2020 Jan 1 [cited 2020 May 25];2020. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsdoj&AN=edsdoj.810e6dd53c344779975403fe7a1e596e&custid=s8280428