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Airborne protein concentration: a key metric for type 1 allergy risk assessment—in home measurement challenges and considerations

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  • معلومة اضافية
    • Publication Information:
      BMC, 2018.
    • Publication Date:
      2018
    • Collection:
      LCC:Immunologic diseases. Allergy
    • Abstract:
      Abstract Background Exposure to airborne proteins can be associated with the development of immediate, IgE-mediated respiratory allergies, with genetic, epigenetic and environmental factors also playing a role in determining the likelihood that sensitisation will be induced. The main objective of this study was to determine whether airborne concentrations of selected common aeroallergens could be quantified in the air of homes using easily deployable, commercially available equipment and analytical methods, at low levels relevant to risk assessment of the potential to develop respiratory allergies. Additionally, air and dust sampling were compared and the influence of factors such as different filter types on allergen quantification explored. Methods Low volume air sampling pumps and DUSTREAM® dust samplers were used to sample 20 homes and allergen levels were quantified using a MARIA® immunoassay. Results It proved possible to detect a range of common aeroallergens in the home with sufficient sensitivity to quantify airborne concentrations in ranges relevant to risk assessment (Limits of Detection of 0.005–0.03 ng/m3). The methodology discriminates between homes related to pet ownership and there were clear advantages to sampling air over dust which are described in this paper. Furthermore, in an adsorption–extraction study, PTFE (polytetrafluoroethylene) filters gave higher and more consistent recovery values than glass fibre (grade A) filters for the range of aeroallergens studied. Conclusions Very low airborne concentrations of allergenic proteins in home settings can be successfully quantified using commercially available pumps and immunoassays. Considering the greater relevance of air sampling to human exposure of the respiratory tract and its other advantages, wider use of standardised, sensitive techniques to measure low airborne protein concentrations and how they influence development of allergic sensitisation and symptoms could accelerate our understanding of human dose–response relationships and refine our knowledge of thresholds of allergic sensitisation and elicitation via the respiratory tract.
    • File Description:
      electronic resource
    • ISSN:
      2045-7022
    • Relation:
      http://link.springer.com/article/10.1186/s13601-018-0196-9; https://doaj.org/toc/2045-7022
    • Accession Number:
      10.1186/s13601-018-0196-9
    • Rights:
      Journal Licence: CC BY
    • Accession Number:
      edsdoj.6840cbb1a9fd4dfe9066ddd468355e8e
  • Citations
    • ABNT:
      LIZ TULUM et al. Airborne protein concentration: a key metric for type 1 allergy risk assessment—in home measurement challenges and considerations. Clinical and Translational Allergy, [s. l.], v. 8, n. 1, p. 1–9, 2018. DOI 10.1186/s13601-018-0196-9. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsdoj&AN=edsdoj.6840cbb1a9fd4dfe9066ddd468355e8e&custid=s8280428. Acesso em: 26 out. 2020.
    • AMA:
      Liz Tulum, Zoë Deag, Matthew Brown, et al. Airborne protein concentration: a key metric for type 1 allergy risk assessment—in home measurement challenges and considerations. Clinical and Translational Allergy. 2018;8(1):1-9. doi:10.1186/s13601-018-0196-9
    • APA:
      Liz Tulum, Zoë Deag, Matthew Brown, Annette Furniss, Lynn Meech, Anja Lalljie, & Stella Cochrane. (2018). Airborne protein concentration: a key metric for type 1 allergy risk assessment—in home measurement challenges and considerations. Clinical and Translational Allergy, 8(1), 1–9. https://doi.org/10.1186/s13601-018-0196-9
    • Chicago/Turabian: Author-Date:
      Liz Tulum, Zoë Deag, Matthew Brown, Annette Furniss, Lynn Meech, Anja Lalljie, and Stella Cochrane. 2018. “Airborne Protein Concentration: A Key Metric for Type 1 Allergy Risk Assessment—in Home Measurement Challenges and Considerations.” Clinical and Translational Allergy 8 (1): 1–9. doi:10.1186/s13601-018-0196-9.
    • Harvard:
      Liz Tulum et al. (2018) ‘Airborne protein concentration: a key metric for type 1 allergy risk assessment—in home measurement challenges and considerations’, Clinical and Translational Allergy, 8(1), pp. 1–9. doi: 10.1186/s13601-018-0196-9.
    • Harvard: Australian:
      Liz Tulum, Zoë Deag, Matthew Brown, Annette Furniss, Lynn Meech, Anja Lalljie & Stella Cochrane 2018, ‘Airborne protein concentration: a key metric for type 1 allergy risk assessment—in home measurement challenges and considerations’, Clinical and Translational Allergy, vol. 8, no. 1, pp. 1–9, viewed 26 October 2020, .
    • MLA:
      Liz Tulum, et al. “Airborne Protein Concentration: A Key Metric for Type 1 Allergy Risk Assessment—in Home Measurement Challenges and Considerations.” Clinical and Translational Allergy, vol. 8, no. 1, Mar. 2018, pp. 1–9. EBSCOhost, doi:10.1186/s13601-018-0196-9.
    • Chicago/Turabian: Humanities:
      Liz Tulum, Zoë Deag, Matthew Brown, Annette Furniss, Lynn Meech, Anja Lalljie, and Stella Cochrane. “Airborne Protein Concentration: A Key Metric for Type 1 Allergy Risk Assessment—in Home Measurement Challenges and Considerations.” Clinical and Translational Allergy 8, no. 1 (March 1, 2018): 1–9. doi:10.1186/s13601-018-0196-9.
    • Vancouver/ICMJE:
      Liz Tulum, Zoë Deag, Matthew Brown, Annette Furniss, Lynn Meech, Anja Lalljie, et al. Airborne protein concentration: a key metric for type 1 allergy risk assessment—in home measurement challenges and considerations. Clinical and Translational Allergy [Internet]. 2018 Mar 1 [cited 2020 Oct 26];8(1):1–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsdoj&AN=edsdoj.6840cbb1a9fd4dfe9066ddd468355e8e&custid=s8280428