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Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India

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  • معلومة اضافية
    • Publication Information:
      Nature Publishing Group, 2020.
    • Publication Date:
      2020
    • Collection:
      LCC:Immunologic diseases. Allergy
      LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
    • Abstract:
      Abstract Identification of the causes of poor oral vaccine immunogenicity in low-income countries might lead to more effective vaccines. We measured mucosal and systemic immune parameters at the time of vaccination with oral poliovirus vaccine (OPV) in 292 Indian infants aged 6–11 months, including plasma cytokines, leukocyte counts, fecal biomarkers of environmental enteropathy and peripheral blood T-cell phenotype, focused on gut-homing regulatory CD4+ populations. We did not find a distinct immune phenotype associated with OPV immunogenicity, although viral pathogens were more prevalent in stool at the time of immunization among infants who failed to seroconvert (63.9% vs. 45.6%, p = 0.002). Using a machine-learning approach, we could predict seroconversion a priori using immune parameters and infection status with a median 58% accuracy (cross-validation IQR: 50–69%) compared with 50% expected by chance. Better identification of immune predictors of OPV immunogenicity is likely to require sampling of mucosal tissue and improved oral poliovirus infection models.
    • File Description:
      electronic resource
    • ISSN:
      2059-0105
    • Relation:
      http://link.springer.com/article/10.1038/s41541-020-0178-5; https://doaj.org/toc/2059-0105
    • Accession Number:
      10.1038/s41541-020-0178-5
    • Rights:
      Journal Licence: CC BY
    • Accession Number:
      edsdoj.5a2aa9b569864a2993e743c2d764ab11
  • Citations
    • ABNT:
      SUDHIR BABJI et al. Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India. npj Vaccines, [s. l.], v. 5, n. 1, p. 1–8, 2020. DOI 10.1038/s41541-020-0178-5. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsdoj&AN=edsdoj.5a2aa9b569864a2993e743c2d764ab11&custid=s8280428. Acesso em: 2 jun. 2020.
    • AMA:
      Sudhir Babji, Punithavathy Manickavasagam, Yin-Huai Chen, et al. Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India. npj Vaccines. 2020;5(1):1-8. doi:10.1038/s41541-020-0178-5.
    • APA:
      Sudhir Babji, Punithavathy Manickavasagam, Yin-Huai Chen, Nithya Jeyavelu, Nisha Vincy Jose, Ira Praharaj, Chanduni Syed, Saravanakumar Puthupalayam Kaliappan, Jacob John, Sidhartha Giri, Srinivasan Venugopal, Beate Kampmann, Edward P. K. Parker, Miren Iturriza-Gómara, Gagandeep Kang, Nicholas C. Grassly, & Holm H. Uhlig. (2020). Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India. Npj Vaccines, 5(1), 1–8. https://doi.org/10.1038/s41541-020-0178-5
    • Chicago/Turabian: Author-Date:
      Sudhir Babji, Punithavathy Manickavasagam, Yin-Huai Chen, Nithya Jeyavelu, Nisha Vincy Jose, Ira Praharaj, Chanduni Syed, et al. 2020. “Immune Predictors of Oral Poliovirus Vaccine Immunogenicity among Infants in South India.” Npj Vaccines 5 (1): 1–8. doi:10.1038/s41541-020-0178-5.
    • Harvard:
      Sudhir Babji et al. (2020) ‘Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India’, npj Vaccines, 5(1), pp. 1–8. doi: 10.1038/s41541-020-0178-5.
    • Harvard: Australian:
      Sudhir Babji, Punithavathy Manickavasagam, Yin-Huai Chen, Nithya Jeyavelu, Nisha Vincy Jose, Ira Praharaj, Chanduni Syed, Saravanakumar Puthupalayam Kaliappan, Jacob John, Sidhartha Giri, Srinivasan Venugopal, Beate Kampmann, Edward P. K. Parker, Miren Iturriza-Gómara, Gagandeep Kang, Nicholas C. Grassly & Holm H. Uhlig 2020, ‘Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India’, npj Vaccines, vol. 5, no. 1, pp. 1–8, viewed 2 June 2020, .
    • MLA:
      Sudhir Babji, et al. “Immune Predictors of Oral Poliovirus Vaccine Immunogenicity among Infants in South India.” Npj Vaccines, vol. 5, no. 1, Mar. 2020, pp. 1–8. EBSCOhost, doi:10.1038/s41541-020-0178-5.
    • Chicago/Turabian: Humanities:
      Sudhir Babji, Punithavathy Manickavasagam, Yin-Huai Chen, Nithya Jeyavelu, Nisha Vincy Jose, Ira Praharaj, Chanduni Syed, et al. “Immune Predictors of Oral Poliovirus Vaccine Immunogenicity among Infants in South India.” Npj Vaccines 5, no. 1 (March 1, 2020): 1–8. doi:10.1038/s41541-020-0178-5.
    • Vancouver/ICMJE:
      Sudhir Babji, Punithavathy Manickavasagam, Yin-Huai Chen, Nithya Jeyavelu, Nisha Vincy Jose, Ira Praharaj, et al. Immune predictors of oral poliovirus vaccine immunogenicity among infants in South India. npj Vaccines [Internet]. 2020 Mar 1 [cited 2020 Jun 2];5(1):1–8. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsdoj&AN=edsdoj.5a2aa9b569864a2993e743c2d764ab11&custid=s8280428