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T Cell Vaccination Inhibits Th1/Th17/Tfh Frequencies and Production of Autoantibodies in Collagen-Induced Arthritis

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  • معلومة اضافية
    • Publication Information:
      Hindawi Publishing Corporation, 2013.
    • Publication Date:
      2013
    • Collection:
      Hindawi_Publishing_Corporation
      DOAJ-Articles_enriched
      DOAJ-Articles
      Hindawi_Publishing_Corporation_enriched
    • Abstract:
      The aim of this study is to determine whether the regulatory role of T cell vaccination (TCV) is through inhibition of Th1/Th17/Tfh and production of autoantibodies on collagen-induced arthritis (CIA). First, CIA mice were treated with TCV. After disease onset, the incidence and severity of change in joint histopathology were evaluated. Mice in the TCV-treated group showed less disease severity and less infiltration of inflammatory cells in the joint sections. TCV decreased the frequencies of Th1/Th17/Tfh cells and related cytokines. Reduction of IL-21 may be associated with both Tfh and Th17, which further influence B cell and T cell responses. In addition, inhibition of Th1/Th17/Tfh frequencies led to the reduced expression of T-bet, RORα, RORγt, and Bcl6. Lastly, the proliferation of type-II-collagen-(CII-) specific T cells and the production of anti-CII antibodies were inhibited in the TCV-treated group. The results provide novel evidence that the therapeutic effects of TCV on CIA are associated with the inhibition of Th1/Th17/Tfh frequencies and autoantibodies production.
    • Accession Number:
      pmc: PMC3865644
      pmid: 24363764
    • File Description:
      text/xhtml
    • ISSN:
      1740-2530
      1740-2522
    • Accession Number:
      10.1155/2013/967301
    • Accession Number:
      edsair.dedup.wf.001..feee819bbb68e0093a9cef53a4bf299a
  • Citations
    • ABNT:
      LI, S. et al. T Cell Vaccination Inhibits Th1/Th17/Tfh Frequencies and Production of Autoantibodies in Collagen-Induced Arthritis. Clinical and Developmental Immunology, [s. l.], v. 2013, 2013. DOI 10.1155/2013/967301. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsair&AN=edsair.dedup.wf.001..feee819bbb68e0093a9cef53a4bf299a&custid=s8280428. Acesso em: 14 jul. 2020.
    • AMA:
      Li S, Niu X, Xi Y, et al. T Cell Vaccination Inhibits Th1/Th17/Tfh Frequencies and Production of Autoantibodies in Collagen-Induced Arthritis. Clinical and Developmental Immunology. 2013;2013. doi:10.1155/2013/967301.
    • AMA11:
      Li S, Niu X, Xi Y, et al. T Cell Vaccination Inhibits Th1/Th17/Tfh Frequencies and Production of Autoantibodies in Collagen-Induced Arthritis. Clinical and Developmental Immunology. 2013;2013. doi:10.1155/2013/967301
    • APA:
      Li, S., Niu, X., Xi, Y., Deng, S., Li, C., Zhao, Q., & Chen, G. (2013). T Cell Vaccination Inhibits Th1/Th17/Tfh Frequencies and Production of Autoantibodies in Collagen-Induced Arthritis. Clinical and Developmental Immunology, 2013. https://doi.org/10.1155/2013/967301
    • Chicago/Turabian: Author-Date:
      Li, Shan, Xiaoyin Niu, Yebin Xi, Shaohua Deng, Chengzhen Li, Qing Zhao, and Guangjie Chen. 2013. “T Cell Vaccination Inhibits Th1/Th17/Tfh Frequencies and Production of Autoantibodies in Collagen-Induced Arthritis.” Clinical and Developmental Immunology 2013 (December). doi:10.1155/2013/967301.
    • Harvard:
      Li, S. et al. (2013) ‘T Cell Vaccination Inhibits Th1/Th17/Tfh Frequencies and Production of Autoantibodies in Collagen-Induced Arthritis’, Clinical and Developmental Immunology, 2013. doi: 10.1155/2013/967301.
    • Harvard: Australian:
      Li, S, Niu, X, Xi, Y, Deng, S, Li, C, Zhao, Q & Chen, G 2013, ‘T Cell Vaccination Inhibits Th1/Th17/Tfh Frequencies and Production of Autoantibodies in Collagen-Induced Arthritis’, Clinical and Developmental Immunology, vol. 2013, viewed 14 July 2020, .
    • MLA:
      Li, Shan, et al. “T Cell Vaccination Inhibits Th1/Th17/Tfh Frequencies and Production of Autoantibodies in Collagen-Induced Arthritis.” Clinical and Developmental Immunology, vol. 2013, Dec. 2013. EBSCOhost, doi:10.1155/2013/967301.
    • Chicago/Turabian: Humanities:
      Li, Shan, Xiaoyin Niu, Yebin Xi, Shaohua Deng, Chengzhen Li, Qing Zhao, and Guangjie Chen. “T Cell Vaccination Inhibits Th1/Th17/Tfh Frequencies and Production of Autoantibodies in Collagen-Induced Arthritis.” Clinical and Developmental Immunology 2013 (December 1, 2013). doi:10.1155/2013/967301.
    • Vancouver/ICMJE:
      Li S, Niu X, Xi Y, Deng S, Li C, Zhao Q, et al. T Cell Vaccination Inhibits Th1/Th17/Tfh Frequencies and Production of Autoantibodies in Collagen-Induced Arthritis. Clinical and Developmental Immunology [Internet]. 2013 Dec 1 [cited 2020 Jul 14];2013. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsair&AN=edsair.dedup.wf.001..feee819bbb68e0093a9cef53a4bf299a&custid=s8280428