Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Induction of Antinuclear Antibodies by De Novo Autoimmune Hepatitis Regulates Alloimmune Responses in Rat Liver Transplantation

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • معلومة اضافية
    • Publication Information:
      Hindawi Publishing Corporation, 2013.
    • Publication Date:
      2013
    • Collection:
      Hindawi_Publishing_Corporation
      DOAJ-Articles_enriched
      DOAJ-Articles
      Hindawi_Publishing_Corporation_enriched
    • Abstract:
      Concanavalin A (Con A) is a lectin originating from the jack-bean and well known for its ability to stimulate T cells and induce autoimmune hepatitis. We previously demonstrated the induction of immunosuppressive antinuclear autoantibody in the course of Con A-induced transient autoimmune hepatitis. This study aimed to clarify the effects of Con A-induced hepatitis on liver allograft rejection and acceptance. In this study, we observed the unique phenomenon that the induction of transient de novo autoimmune hepatitis by Con A injection paradoxically overcomes the rejection without any immunosuppressive drug and exhibits significantly prolonged survival after orthotopic liver transplantation (OLT). Significantly increased titers of anti-nuclear Abs against histone H1 and high-mobility group box 1 (HMGB1) and reduced donor specific alloantibody response were observed in Con A-injected recipients. Induction of Foxp3 and IL-10 in OLT livers of Con A-injected recipients suggested the involvement of regulatory T cells in this unique phenomenon. Our present data suggest the significance of autoimmune responses against nuclear histone H1 and HMGB1 for competing allogeneic immune responses, resulting in the acceptance of liver allografts in experimental liver transplantation.
    • Accession Number:
      pmc: PMC3886613
      pmid: 24454474
    • File Description:
      text/xhtml
    • ISSN:
      1740-2530
      1740-2522
    • Accession Number:
      10.1155/2013/413928
    • Accession Number:
      edsair.dedup.wf.001..8050f585b105989919090668c097ae17
  • Citations
    • ABNT:
      CHIU, K.-W. et al. Induction of Antinuclear Antibodies by De Novo Autoimmune Hepatitis Regulates Alloimmune Responses in Rat Liver Transplantation. Clinical and Developmental Immunology, [s. l.], v. 2013, 2013. DOI 10.1155/2013/413928. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsair&AN=edsair.dedup.wf.001..8050f585b105989919090668c097ae17&custid=s8280428. Acesso em: 28 out. 2020.
    • AMA:
      Chiu K-W, Nakano T, Goto S, et al. Induction of Antinuclear Antibodies by De Novo Autoimmune Hepatitis Regulates Alloimmune Responses in Rat Liver Transplantation. Clinical and Developmental Immunology. 2013;2013. doi:10.1155/2013/413928
    • APA:
      Chiu, K.-W., Nakano, T., Goto, S., Lai, C.-Y., Hsu, L.-W., Tseng, H.-P., Chen, K.-D., Wang, C.-C., Cheng, Y.-F., & Chen, C.-L. (2013). Induction of Antinuclear Antibodies by De Novo Autoimmune Hepatitis Regulates Alloimmune Responses in Rat Liver Transplantation. Clinical and Developmental Immunology, 2013. https://doi.org/10.1155/2013/413928
    • Chicago/Turabian: Author-Date:
      Chiu, King-Wah, Toshiaki Nakano, Shigeru Goto, Chia-Yun Lai, Li-Wen Hsu, Hui-Peng Tseng, Kuang-Den Chen, Chih-Chi Wang, Yu-Fan Cheng, and Chao-Long Chen. 2013. “Induction of Antinuclear Antibodies by De Novo Autoimmune Hepatitis Regulates Alloimmune Responses in Rat Liver Transplantation.” Clinical and Developmental Immunology 2013 (December). doi:10.1155/2013/413928.
    • Harvard:
      Chiu, K.-W. et al. (2013) ‘Induction of Antinuclear Antibodies by De Novo Autoimmune Hepatitis Regulates Alloimmune Responses in Rat Liver Transplantation’, Clinical and Developmental Immunology, 2013. doi: 10.1155/2013/413928.
    • Harvard: Australian:
      Chiu, K-W, Nakano, T, Goto, S, Lai, C-Y, Hsu, L-W, Tseng, H-P, Chen, K-D, Wang, C-C, Cheng, Y-F & Chen, C-L 2013, ‘Induction of Antinuclear Antibodies by De Novo Autoimmune Hepatitis Regulates Alloimmune Responses in Rat Liver Transplantation’, Clinical and Developmental Immunology, vol. 2013, viewed 28 October 2020, .
    • MLA:
      Chiu, King-Wah, et al. “Induction of Antinuclear Antibodies by De Novo Autoimmune Hepatitis Regulates Alloimmune Responses in Rat Liver Transplantation.” Clinical and Developmental Immunology, vol. 2013, Dec. 2013. EBSCOhost, doi:10.1155/2013/413928.
    • Chicago/Turabian: Humanities:
      Chiu, King-Wah, Toshiaki Nakano, Shigeru Goto, Chia-Yun Lai, Li-Wen Hsu, Hui-Peng Tseng, Kuang-Den Chen, Chih-Chi Wang, Yu-Fan Cheng, and Chao-Long Chen. “Induction of Antinuclear Antibodies by De Novo Autoimmune Hepatitis Regulates Alloimmune Responses in Rat Liver Transplantation.” Clinical and Developmental Immunology 2013 (December 1, 2013). doi:10.1155/2013/413928.
    • Vancouver/ICMJE:
      Chiu K-W, Nakano T, Goto S, Lai C-Y, Hsu L-W, Tseng H-P, et al. Induction of Antinuclear Antibodies by De Novo Autoimmune Hepatitis Regulates Alloimmune Responses in Rat Liver Transplantation. Clinical and Developmental Immunology [Internet]. 2013 Dec 1 [cited 2020 Oct 28];2013. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsair&AN=edsair.dedup.wf.001..8050f585b105989919090668c097ae17&custid=s8280428