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Aging with HIV vs. HIV Seroconversion at Older Age: A Diverse Population with Distinct Comorbidity Profiles

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  • معلومة اضافية
    • Publication Information:
      Public Library of Science (PLoS), 2015.
    • Publication Date:
      2015
    • Collection:
      DOAJ-Articles_enriched
      DOAJ-Articles
    • Abstract:
      Objective People aging with HIV might have different health conditions compared with people who seroconverted at older ages. The study objective was to assess the prevalence of, and risk factors for, individual co-morbidities and multimorbidity (MM) between HIV-positive patients with a longer duration of HIV infection, and patients who seroconverted at an older age. We compared estimates across both groups to a matched community-based cohort sampled from the general population. Methods We performed a case-control study including antiretroviral therapy (ART)–experienced patients who were HIV seropositive for ≥ 20.6 years (“HIV-Aging”), or who were seropositive for < 11.3 years (“HIV-Aged”) having access in 2013 at the Modena HIV Metabolic Clinic. Patients were matched in a 1:3 ratio with controls from the CINECA ARNO database. MM was defined as the concurrent presence of >2 NICM. Logistic regression models were constructed to evaluate associated predictors of NICM and MM. Results We analysed 404 HIV-Aging and 404 HIV-Aged participants in comparison to 2424 controls. The mean age was 46.7±6.2 years, 28.9% were women. Prevalence of HIV co-morbidities and MM were significantly higher in the HIV-positive groups compared to the general population (p<0.001) and a trend towards higher rates of MM was found in aging vs aged group. This difference turned to be significant in patients above the age of 45 years old (p<0.001). Conclusions People aging with HIV display heterogeneous health conditions. Host factors and duration of HIV infection are associated with increased risk of MM compared to the general population.
    • Accession Number:
      pmc: PMC4395353
      pmid: 25874806
    • ISSN:
      1932-6203
    • Accession Number:
      10.1371/journal.pone.0118531
    • Accession Number:
      edsair.dedup.wf.001..671a7a085e118d14be70af78c5330be4
  • Citations
    • ABNT:
      GUARALDI, G. et al. Aging with HIV vs. HIV Seroconversion at Older Age: A Diverse Population with Distinct Comorbidity Profiles. [s. l.], v. 10, 2015. DOI 10.1371/journal.pone.0118531. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsair&AN=edsair.dedup.wf.001..671a7a085e118d14be70af78c5330be4&custid=s8280428. Acesso em: 1 abr. 2020.
    • AMA:
      Guaraldi G, Zona S, Brothers TD, et al. Aging with HIV vs. HIV Seroconversion at Older Age: A Diverse Population with Distinct Comorbidity Profiles. 2015;10. doi:10.1371/journal.pone.0118531.
    • APA:
      Guaraldi, G., Zona, S., Brothers, T. D., Carli, F., Stentarelli, C., Dolci, G., Santoro, A., Beghetto, B., Menozzi, M., Mussini, C., & Falutz, J. (2015). Aging with HIV vs. HIV Seroconversion at Older Age: A Diverse Population with Distinct Comorbidity Profiles. 10. https://doi.org/10.1371/journal.pone.0118531
    • Chicago/Turabian: Author-Date:
      Guaraldi, Giovanni, Stefano Zona, Thomas D Brothers, Federica Carli, Chiara Stentarelli, Giovanni Dolci, Antonella Santoro, et al. 2015. “Aging with HIV vs. HIV Seroconversion at Older Age: A Diverse Population with Distinct Comorbidity Profiles” 10 (January). doi:10.1371/journal.pone.0118531.
    • Harvard:
      Guaraldi, G. et al. (2015) ‘Aging with HIV vs. HIV Seroconversion at Older Age: A Diverse Population with Distinct Comorbidity Profiles’, 10. doi: 10.1371/journal.pone.0118531.
    • Harvard: Australian:
      Guaraldi, G, Zona, S, Brothers, TD, Carli, F, Stentarelli, C, Dolci, G, Santoro, A, Beghetto, B, Menozzi, M, Mussini, C & Falutz, J 2015, ‘Aging with HIV vs. HIV Seroconversion at Older Age: A Diverse Population with Distinct Comorbidity Profiles’, vol. 10, viewed 1 April 2020, .
    • MLA:
      Guaraldi, Giovanni, et al. Aging with HIV vs. HIV Seroconversion at Older Age: A Diverse Population with Distinct Comorbidity Profiles. Vol. 10, Jan. 2015. EBSCOhost, doi:10.1371/journal.pone.0118531.
    • Chicago/Turabian: Humanities:
      Guaraldi, Giovanni, Stefano Zona, Thomas D Brothers, Federica Carli, Chiara Stentarelli, Giovanni Dolci, Antonella Santoro, et al. “Aging with HIV vs. HIV Seroconversion at Older Age: A Diverse Population with Distinct Comorbidity Profiles” 10 (January 1, 2015). doi:10.1371/journal.pone.0118531.
    • Vancouver/ICMJE:
      Guaraldi G, Zona S, Brothers TD, Carli F, Stentarelli C, Dolci G, et al. Aging with HIV vs. HIV Seroconversion at Older Age: A Diverse Population with Distinct Comorbidity Profiles. 2015 Jan 1 [cited 2020 Apr 1];10. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsair&AN=edsair.dedup.wf.001..671a7a085e118d14be70af78c5330be4&custid=s8280428