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Mesenchymal Stem Cells in Immune-Mediated Bone Marrow Failure Syndromes

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  • معلومة اضافية
    • Publication Information:
      Hindawi Publishing Corporation, 2013.
    • Publication Date:
      2013
    • Collection:
      Hindawi_Publishing_Corporation
      DOAJ-Articles_enriched
      DOAJ-Articles
      Hindawi_Publishing_Corporation_enriched
    • Abstract:
      Immune-mediated bone marrow failure syndromes (BMFS) are characterized by ineffective marrow haemopoiesis and subsequent peripheral cytopenias. Ineffective haemopoiesis is the result of a complex marrow deregulation including genetic, epigenetic, and immune-mediated alterations in haemopoietic stem/progenitor cells, as well as abnormal haemopoietic-to-stromal cell interactions, with abnormal release of haemopoietic growth factors, chemokines, and inhibitors. Mesenchymal stem/stromal cells (MSCs) and their progeny (i.e., osteoblasts, adipocytes, and reticular cells) are considered as key cellular components of the bone marrow haemopoietic niche. MSCs may interfere with haemopoietic as well as immune regulation. Evidence suggests that bone marrow MSCs may be involved in immune-mediated BMFS underlying pathophysiology, harboring either native abnormalities and/or secondary defects, caused by exposure to activated marrow components. This review summarizes previous as well as more recent information related to the biologic/functional characteristics of bone marrow MSCs in myelodysplastic syndromes, acquired aplastic anemia, and chronic idiopathic neutropenia.
    • Accession Number:
      pmc: PMC3872391
      pmid: 24386000
    • File Description:
      text/xhtml
    • ISSN:
      1740-2530
      1740-2522
    • Accession Number:
      10.1155/2013/265608
    • Accession Number:
      edsair.dedup.wf.001..5cb8554c4d24fb5f496ab8cde8e4870f
  • Citations
    • ABNT:
      KASTRINAKI, M.-C. et al. Mesenchymal Stem Cells in Immune-Mediated Bone Marrow Failure Syndromes. Clinical and Developmental Immunology, [s. l.], v. 2013, 2013. DOI 10.1155/2013/265608. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsair&AN=edsair.dedup.wf.001..5cb8554c4d24fb5f496ab8cde8e4870f&custid=s8280428. Acesso em: 14 jul. 2020.
    • AMA:
      Kastrinaki M-C, Pavlaki K, Batsali AK, et al. Mesenchymal Stem Cells in Immune-Mediated Bone Marrow Failure Syndromes. Clinical and Developmental Immunology. 2013;2013. doi:10.1155/2013/265608.
    • AMA11:
      Kastrinaki M-C, Pavlaki K, Batsali AK, et al. Mesenchymal Stem Cells in Immune-Mediated Bone Marrow Failure Syndromes. Clinical and Developmental Immunology. 2013;2013. doi:10.1155/2013/265608
    • APA:
      Kastrinaki, M.-C., Pavlaki, K., Batsali, A. K., Kouvidi, E., Mavroudi, I., Pontikoglou, C., & Papadaki, H. A. (2013). Mesenchymal Stem Cells in Immune-Mediated Bone Marrow Failure Syndromes. Clinical and Developmental Immunology, 2013. https://doi.org/10.1155/2013/265608
    • Chicago/Turabian: Author-Date:
      Kastrinaki, Maria-Christina, Konstantia Pavlaki, Aristea K. Batsali, Elisavet Kouvidi, Irene Mavroudi, Charalampos Pontikoglou, and Helen A. Papadaki. 2013. “Mesenchymal Stem Cells in Immune-Mediated Bone Marrow Failure Syndromes.” Clinical and Developmental Immunology 2013 (December). doi:10.1155/2013/265608.
    • Harvard:
      Kastrinaki, M.-C. et al. (2013) ‘Mesenchymal Stem Cells in Immune-Mediated Bone Marrow Failure Syndromes’, Clinical and Developmental Immunology, 2013. doi: 10.1155/2013/265608.
    • Harvard: Australian:
      Kastrinaki, M-C, Pavlaki, K, Batsali, AK, Kouvidi, E, Mavroudi, I, Pontikoglou, C & Papadaki, HA 2013, ‘Mesenchymal Stem Cells in Immune-Mediated Bone Marrow Failure Syndromes’, Clinical and Developmental Immunology, vol. 2013, viewed 14 July 2020, .
    • MLA:
      Kastrinaki, Maria-Christina, et al. “Mesenchymal Stem Cells in Immune-Mediated Bone Marrow Failure Syndromes.” Clinical and Developmental Immunology, vol. 2013, Dec. 2013. EBSCOhost, doi:10.1155/2013/265608.
    • Chicago/Turabian: Humanities:
      Kastrinaki, Maria-Christina, Konstantia Pavlaki, Aristea K. Batsali, Elisavet Kouvidi, Irene Mavroudi, Charalampos Pontikoglou, and Helen A. Papadaki. “Mesenchymal Stem Cells in Immune-Mediated Bone Marrow Failure Syndromes.” Clinical and Developmental Immunology 2013 (December 1, 2013). doi:10.1155/2013/265608.
    • Vancouver/ICMJE:
      Kastrinaki M-C, Pavlaki K, Batsali AK, Kouvidi E, Mavroudi I, Pontikoglou C, et al. Mesenchymal Stem Cells in Immune-Mediated Bone Marrow Failure Syndromes. Clinical and Developmental Immunology [Internet]. 2013 Dec 1 [cited 2020 Jul 14];2013. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsair&AN=edsair.dedup.wf.001..5cb8554c4d24fb5f496ab8cde8e4870f&custid=s8280428