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Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRL/lpr Mouse Models of Systemic Lupus Erythematosus-Like Disease

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  • معلومة اضافية
    • Publication Information:
      Hindawi Publishing Corporation, 2013.
    • Publication Date:
      2013
    • Collection:
      Hindawi_Publishing_Corporation
      DOAJ-Articles_enriched
      DOAJ-Articles
      Hindawi_Publishing_Corporation_enriched
    • Abstract:
      Prolactin (PRL) plays an important role in modulating the immune response. In B cells, PRL enhances antibody production, including antibodies with self-specificity. In this study, our aims were to determine the level of PRL receptor expression during bone-marrow B-cell development and to assess whether the presence of high PRL serum concentrations influences absolute numbers of developing populations and disease outcome in lupus-prone murine models. We observed that the PRL-receptor is expressed in early bone-marrow B-cell; the expression in lupus-prone mice, which had the highest level of expression in pro-B cells and immature cells, differed from that in wild-type mice. These expression levels did not significantly change in response to hyperprolactinemia; however, populations of pro-B and immature cells from lupus-prone strains showed a decrease in the absolute numbers of cells with high PRL-receptor expression in response to PRL. Because immature self-reactive B cells are constantly being eliminated, we assessed the expression of survival factor BIRC5, which is more highly expressed in both pro-B and immature B-cells in response to PRL and correlates with the onset of disease. These results identify an important role of PRL in the early stages of the B-cell maturation process: PRL may promote the survival of self-reactive clones.
    • Accession Number:
      pmc: PMC3878598
      pmid: 24454471
    • File Description:
      text/xhtml
    • ISSN:
      1740-2530
      1740-2522
    • Accession Number:
      10.1155/2013/287469
    • Accession Number:
      edsair.dedup.wf.001..54165e720454c626f9baa278311a1b32
  • Citations
    • ABNT:
      LEGORRETA-HAQUET, M. V. et al. Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRL/lpr Mouse Models of Systemic Lupus Erythematosus-Like Disease. Clinical and Developmental Immunology, [s. l.], v. 2013, 2013. DOI 10.1155/2013/287469. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsair&AN=edsair.dedup.wf.001..54165e720454c626f9baa278311a1b32&custid=s8280428. Acesso em: 14 jul. 2020.
    • AMA:
      Legorreta-Haquet MV, Flores-Fernández R, Blanco-Favela F, et al. Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRL/lpr Mouse Models of Systemic Lupus Erythematosus-Like Disease. Clinical and Developmental Immunology. 2013;2013. doi:10.1155/2013/287469.
    • AMA11:
      Legorreta-Haquet MV, Flores-Fernández R, Blanco-Favela F, et al. Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRL/lpr Mouse Models of Systemic Lupus Erythematosus-Like Disease. Clinical and Developmental Immunology. 2013;2013. doi:10.1155/2013/287469
    • APA:
      Legorreta-Haquet, M. V., Flores-Fernández, R., Blanco-Favela, F., Fuentes-Pananá, E. M., Chávez-Sánchez, L., Hernández-González, R., Tesoro-Cruz, E., Arriaga-Pizano, L., & Chávez-Rueda, A. K. (2013). Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRL/lpr Mouse Models of Systemic Lupus Erythematosus-Like Disease. Clinical and Developmental Immunology, 2013. https://doi.org/10.1155/2013/287469
    • Chicago/Turabian: Author-Date:
      Legorreta-Haquet, Maria Victoria, Rocio Flores-Fernández, Francisco Blanco-Favela, Ezequiel M Fuentes-Pananá, Luis Chávez-Sánchez, Rafael Hernández-González, Emiliano Tesoro-Cruz, Lourdes Arriaga-Pizano, and Adriana Karina Chávez-Rueda. 2013. “Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRL/Lpr Mouse Models of Systemic Lupus Erythematosus-Like Disease.” Clinical and Developmental Immunology 2013 (December). doi:10.1155/2013/287469.
    • Harvard:
      Legorreta-Haquet, M. V. et al. (2013) ‘Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRL/lpr Mouse Models of Systemic Lupus Erythematosus-Like Disease’, Clinical and Developmental Immunology, 2013. doi: 10.1155/2013/287469.
    • Harvard: Australian:
      Legorreta-Haquet, MV, Flores-Fernández, R, Blanco-Favela, F, Fuentes-Pananá, EM, Chávez-Sánchez, L, Hernández-González, R, Tesoro-Cruz, E, Arriaga-Pizano, L & Chávez-Rueda, AK 2013, ‘Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRL/lpr Mouse Models of Systemic Lupus Erythematosus-Like Disease’, Clinical and Developmental Immunology, vol. 2013, viewed 14 July 2020, .
    • MLA:
      Legorreta-Haquet, Maria Victoria, et al. “Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRL/Lpr Mouse Models of Systemic Lupus Erythematosus-Like Disease.” Clinical and Developmental Immunology, vol. 2013, Dec. 2013. EBSCOhost, doi:10.1155/2013/287469.
    • Chicago/Turabian: Humanities:
      Legorreta-Haquet, Maria Victoria, Rocio Flores-Fernández, Francisco Blanco-Favela, Ezequiel M Fuentes-Pananá, Luis Chávez-Sánchez, Rafael Hernández-González, Emiliano Tesoro-Cruz, Lourdes Arriaga-Pizano, and Adriana Karina Chávez-Rueda. “Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRL/Lpr Mouse Models of Systemic Lupus Erythematosus-Like Disease.” Clinical and Developmental Immunology 2013 (December 1, 2013). doi:10.1155/2013/287469.
    • Vancouver/ICMJE:
      Legorreta-Haquet MV, Flores-Fernández R, Blanco-Favela F, Fuentes-Pananá EM, Chávez-Sánchez L, Hernández-González R, et al. Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRL/lpr Mouse Models of Systemic Lupus Erythematosus-Like Disease. Clinical and Developmental Immunology [Internet]. 2013 Dec 1 [cited 2020 Jul 14];2013. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsair&AN=edsair.dedup.wf.001..54165e720454c626f9baa278311a1b32&custid=s8280428