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Cell-Mediated Immune Responses in Paraneoplastic Neurological Syndromes

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  • معلومة اضافية
    • Publication Information:
      Hindawi Publishing Corporation, 2013.
    • Publication Date:
      2013
    • Collection:
      Hindawi_Publishing_Corporation
      DOAJ-Articles_enriched
      DOAJ-Articles
      Hindawi_Publishing_Corporation_enriched
    • Abstract:
      Paraneoplastic neurological syndromes (PNS) are disorders of the nervous system that are associated with remote effects of malignancy. PNS are considered to have an autoimmune pathology. It has been suggested that immune antitumor responses are the origin of improved outcome in PNS. We describe cell-mediated immune responses in PNS and their potential contributions to antitumor reactions. Experimental and neuropathological studies have revealed infiltrates in nervous tissue and disturbances in lymphocyte populations in both cerebrospinal fluid and peripheral blood. A predominance of cytotoxic T lymphocytes (CTLs) over T helper cells has been observed. CTLs can be specifically aggressive against antigens shared by tumors and nervous tissue. Based on genetic studies, a common clonal origin of lymphocytes from blood, tumor, and nervous tissue is suggested. Suppressive regulatory T (Treg) lymphocytes are dysfunctional. Simultaneously, in tumor tissue, more intense cell-mediated immune responses are observed, which often coincide with a less aggressive course of neoplastic disease. An increased titer of onconeural antibodies is also related to better prognoses in patients without PNS. The evaluation of onconeural and neuronal surface antibodies was recommended in current guidelines. The link between PNS emergence and antitumor responses may result from more active CTLs and less functional Treg lymphocytes.
    • Accession Number:
      pmc: PMC3932176
      pmid: 24575143
    • File Description:
      text/xhtml
    • ISSN:
      1740-2530
      1740-2522
    • Accession Number:
      10.1155/2013/630602
    • Accession Number:
      edsair.dedup.wf.001..1420a90c5a8d3f9ae04ed9b08926a9d8
  • Citations
    • ABNT:
      ZABOROWSKI, M. P.; MICHALAK, S. Cell-Mediated Immune Responses in Paraneoplastic Neurological Syndromes. Clinical and Developmental Immunology, [s. l.], v. 2013, 2013. DOI 10.1155/2013/630602. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsair&AN=edsair.dedup.wf.001..1420a90c5a8d3f9ae04ed9b08926a9d8&custid=s8280428. Acesso em: 14 ago. 2020.
    • AMA:
      Zaborowski MP, Michalak S. Cell-Mediated Immune Responses in Paraneoplastic Neurological Syndromes. Clinical and Developmental Immunology. 2013;2013. doi:10.1155/2013/630602
    • APA:
      Zaborowski, M. P., & Michalak, S. (2013). Cell-Mediated Immune Responses in Paraneoplastic Neurological Syndromes. Clinical and Developmental Immunology, 2013. https://doi.org/10.1155/2013/630602
    • Chicago/Turabian: Author-Date:
      Zaborowski, Mikolaj Piotr, and Slawomir Michalak. 2013. “Cell-Mediated Immune Responses in Paraneoplastic Neurological Syndromes.” Clinical and Developmental Immunology 2013 (December). doi:10.1155/2013/630602.
    • Harvard:
      Zaborowski, M. P. and Michalak, S. (2013) ‘Cell-Mediated Immune Responses in Paraneoplastic Neurological Syndromes’, Clinical and Developmental Immunology, 2013. doi: 10.1155/2013/630602.
    • Harvard: Australian:
      Zaborowski, MP & Michalak, S 2013, ‘Cell-Mediated Immune Responses in Paraneoplastic Neurological Syndromes’, Clinical and Developmental Immunology, vol. 2013, viewed 14 August 2020, .
    • MLA:
      Zaborowski, Mikolaj Piotr, and Slawomir Michalak. “Cell-Mediated Immune Responses in Paraneoplastic Neurological Syndromes.” Clinical and Developmental Immunology, vol. 2013, Dec. 2013. EBSCOhost, doi:10.1155/2013/630602.
    • Chicago/Turabian: Humanities:
      Zaborowski, Mikolaj Piotr, and Slawomir Michalak. “Cell-Mediated Immune Responses in Paraneoplastic Neurological Syndromes.” Clinical and Developmental Immunology 2013 (December 1, 2013). doi:10.1155/2013/630602.
    • Vancouver/ICMJE:
      Zaborowski MP, Michalak S. Cell-Mediated Immune Responses in Paraneoplastic Neurological Syndromes. Clinical and Developmental Immunology [Internet]. 2013 Dec 1 [cited 2020 Aug 14];2013. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=edsair&AN=edsair.dedup.wf.001..1420a90c5a8d3f9ae04ed9b08926a9d8&custid=s8280428