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Thigh Muscle Specific-Strength and the Risk of Incident Knee Osteoarthritis: The Influence of Sex and Greater Body Mass Index.

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  • معلومة اضافية
    • Source:
      Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101518086 Publication Model: Print Cited Medium: Internet ISSN: 2151-4658 (Electronic) Linking ISSN: 2151464X NLM ISO Abbreviation: Arthritis Care Res (Hoboken) Subsets: MEDLINE
    • Publication Information:
      Original Publication: Hoboken, NJ : John Wiley & Sons
    • Subject Terms:
    • Abstract:
      Objective: To determine whether lower thigh muscle specific-strength increases the risk of incident radiographic knee osteoarthritis (RKOA), and whether there exists a sex-specific relationship between thigh muscle specific-strength and body mass index (BMI).
      Methods: A total of 161 Osteoarthritis Initiative participants (62% female) with incident RKOA (Kellgren/Lawrence grade 0/1 at baseline, developing an osteophyte and joint space narrowing grade ≥1 by year 4) were matched to 186 controls (58% female) without incident RKOA. Thigh muscle anatomical cross-sectional areas (ACSAs) were determined at baseline using axial magnetic resonance imaging scans. Isometric extensor and flexor muscle strength was measured at baseline, and specific strength (strength ÷ ACSA) was calculated. Logistic regression assessed the risk of incident RKOA associated with muscle specific-strength (with and without adjustment for BMI).
      Results: Lower knee extensor- and flexor-specific strength significantly increased the risk of incident RKOA in women but not in men (odds ratio 1.47 [95% confidence interval (95% CI) 1.10-1.96] and 1.41 [95% CI 1.06-1.89], respectively). The significant relationship in women was lost after adjustment for BMI. Lower specific strength was associated with higher BMI in women (r = -0.29, P < 0.001), but not in men, whereas absolute strength was associated with BMI in men (r = 0.28, P = 0.001), but not in women.
      Conclusion: Lower thigh muscle specific-strength predicts incident RKOA in women, with this relationship being confounded by BMI. The sex-specific relationship between muscle specific-strength and BMI provides a possible explanation why women with muscle-strength deficits typically have a poorer prognosis than men with similar strength deficits.
      (© 2017, American College of Rheumatology.)
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    • Grant Information:
      N01AR22260 United States AR NIAMS NIH HHS; P60 AR047785 United States AR NIAMS NIH HHS; N01 AR022261 United States AR NIAMS NIH HHS; N01 AR022259 United States AR NIAMS NIH HHS; N01 AR022258 United States AR NIAMS NIH HHS; N01 AR022262 United States AR NIAMS NIH HHS
    • Publication Date:
      Date Created: 20170209 Date Completed: 20170831 Latest Revision: 20191220
    • Publication Date:
      20200716
    • Accession Number:
      PMC5532059
    • Accession Number:
      10.1002/acr.23182
    • Accession Number:
      28176489
  • Citations
    • ABNT:
      CULVENOR, A. G. et al. Thigh Muscle Specific-Strength and the Risk of Incident Knee Osteoarthritis: The Influence of Sex and Greater Body Mass Index. Arthritis care & research, [s. l.], v. 69, n. 8, p. 1266–1270, 2017. DOI 10.1002/acr.23182. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=28176489&custid=s8280428. Acesso em: 15 ago. 2020.
    • AMA:
      Culvenor AG, Felson DT, Niu J, et al. Thigh Muscle Specific-Strength and the Risk of Incident Knee Osteoarthritis: The Influence of Sex and Greater Body Mass Index. Arthritis care & research. 2017;69(8):1266-1270. doi:10.1002/acr.23182
    • APA:
      Culvenor, A. G., Felson, D. T., Niu, J., Wirth, W., Sattler, M., Dannhauer, T., & Eckstein, F. (2017). Thigh Muscle Specific-Strength and the Risk of Incident Knee Osteoarthritis: The Influence of Sex and Greater Body Mass Index. Arthritis Care & Research, 69(8), 1266–1270. https://doi.org/10.1002/acr.23182
    • Chicago/Turabian: Author-Date:
      Culvenor, Adam G, David T Felson, Jingbo Niu, Wolfgang Wirth, Martina Sattler, Torben Dannhauer, and Felix Eckstein. 2017. “Thigh Muscle Specific-Strength and the Risk of Incident Knee Osteoarthritis: The Influence of Sex and Greater Body Mass Index.” Arthritis Care & Research 69 (8): 1266–70. doi:10.1002/acr.23182.
    • Harvard:
      Culvenor, A. G. et al. (2017) ‘Thigh Muscle Specific-Strength and the Risk of Incident Knee Osteoarthritis: The Influence of Sex and Greater Body Mass Index’, Arthritis care & research, 69(8), pp. 1266–1270. doi: 10.1002/acr.23182.
    • Harvard: Australian:
      Culvenor, AG, Felson, DT, Niu, J, Wirth, W, Sattler, M, Dannhauer, T & Eckstein, F 2017, ‘Thigh Muscle Specific-Strength and the Risk of Incident Knee Osteoarthritis: The Influence of Sex and Greater Body Mass Index’, Arthritis care & research, vol. 69, no. 8, pp. 1266–1270, viewed 15 August 2020, .
    • MLA:
      Culvenor, Adam G., et al. “Thigh Muscle Specific-Strength and the Risk of Incident Knee Osteoarthritis: The Influence of Sex and Greater Body Mass Index.” Arthritis Care & Research, vol. 69, no. 8, Aug. 2017, pp. 1266–1270. EBSCOhost, doi:10.1002/acr.23182.
    • Chicago/Turabian: Humanities:
      Culvenor, Adam G, David T Felson, Jingbo Niu, Wolfgang Wirth, Martina Sattler, Torben Dannhauer, and Felix Eckstein. “Thigh Muscle Specific-Strength and the Risk of Incident Knee Osteoarthritis: The Influence of Sex and Greater Body Mass Index.” Arthritis Care & Research 69, no. 8 (August 2017): 1266–70. doi:10.1002/acr.23182.
    • Vancouver/ICMJE:
      Culvenor AG, Felson DT, Niu J, Wirth W, Sattler M, Dannhauer T, et al. Thigh Muscle Specific-Strength and the Risk of Incident Knee Osteoarthritis: The Influence of Sex and Greater Body Mass Index. Arthritis care & research [Internet]. 2017 Aug [cited 2020 Aug 15];69(8):1266–70. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=28176489&custid=s8280428