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Magnetic Resonance Imaging-Assessed Vastus Medialis Muscle Fat Content and Risk for Knee Osteoarthritis Progression: Relevance From a Clinical Trial.

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  • معلومة اضافية
    • Source:
      Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101518086 Publication Model: Print Cited Medium: Internet ISSN: 2151-4658 (Electronic) Linking ISSN: 2151464X NLM ISO Abbreviation: Arthritis Care Res (Hoboken) Subsets: MEDLINE
    • Publication Information:
      Original Publication: Hoboken, NJ : John Wiley & Sons
    • Subject Terms:
    • Abstract:
      Objective: Studies have proposed vastus medialis (VM) muscle cross-sectional area change as a variable associated with cartilage volume loss in knee osteoarthritis (OA). However, the VM also includes fat (%Fat), which may influence knee function. This study analyzed the VM area and %Fat data, separately and in combination, to predict symptoms, cartilage volume loss, and bone marrow lesion (BML) change in knee OA.
      Methods: This study included the according-to-protocol population (n = 143) of a 2-year knee OA randomized clinical trial having magnetic resonance imaging at baseline and 2 years. Correlations used multivariate analyses.
      Results: Greater baseline value for VM area and %Fat were significantly associated with sex (male, area; female, %Fat), higher body mass index (BMI), and Western Ontario and McMaster Universities Osteoarthritis Index stiffness, function, and total scores (better, high area; worse, high %Fat). Moreover, a VM %Fat increase of 1% at 2 years was associated with worsening of cartilage volume loss in the global knee (P = 0.015) and some subregions (P ≤ 0.030), and with an increment of BML global score change (P < 0.001). A 1% decrease in VM area at 2 years was associated with worsening of knee pain score (P = 0.048). Importantly, the concurrent presence of low VM area, high VM %Fat, and high BMI identified a subgroup of patients with greater cartilage volume loss in the medial femur (P = 0.028) than the rest of the cohort.
      Conclusion: These data demonstrated, for the first time, that VM fat content is a strong predictor of cartilage volume loss and the occurrence and progression of BML. Importantly, the combined data of VM area, VM %Fat, and BMI identified patients at higher risk for OA progression.
      (© 2015, American College of Rheumatology.)
    • Publication Date:
      Date Created: 20150318 Date Completed: 20151215 Latest Revision: 20150923
    • Publication Date:
      20200716
    • Accession Number:
      10.1002/acr.22590
    • Accession Number:
      25778112
  • Citations
    • ABNT:
      RAYNAULD, J.-P. et al. Magnetic Resonance Imaging-Assessed Vastus Medialis Muscle Fat Content and Risk for Knee Osteoarthritis Progression: Relevance From a Clinical Trial. Arthritis care & research, [s. l.], v. 67, n. 10, p. 1406–1415, 2015. DOI 10.1002/acr.22590. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=25778112&custid=s8280428. Acesso em: 15 ago. 2020.
    • AMA:
      Raynauld J-P, Pelletier J-P, Roubille C, et al. Magnetic Resonance Imaging-Assessed Vastus Medialis Muscle Fat Content and Risk for Knee Osteoarthritis Progression: Relevance From a Clinical Trial. Arthritis care & research. 2015;67(10):1406-1415. doi:10.1002/acr.22590
    • APA:
      Raynauld, J.-P., Pelletier, J.-P., Roubille, C., Dorais, M., Abram, F., Li, W., Wang, Y., Fairley, J., Cicuttini, F. M., & Martel-Pelletier, J. (2015). Magnetic Resonance Imaging-Assessed Vastus Medialis Muscle Fat Content and Risk for Knee Osteoarthritis Progression: Relevance From a Clinical Trial. Arthritis Care & Research, 67(10), 1406–1415. https://doi.org/10.1002/acr.22590
    • Chicago/Turabian: Author-Date:
      Raynauld, Jean-Pierre, Jean-Pierre Pelletier, Camille Roubille, Marc Dorais, François Abram, Wei Li, Yuanyuan Wang, Jessica Fairley, Flavia M Cicuttini, and Johanne Martel-Pelletier. 2015. “Magnetic Resonance Imaging-Assessed Vastus Medialis Muscle Fat Content and Risk for Knee Osteoarthritis Progression: Relevance From a Clinical Trial.” Arthritis Care & Research 67 (10): 1406–15. doi:10.1002/acr.22590.
    • Harvard:
      Raynauld, J.-P. et al. (2015) ‘Magnetic Resonance Imaging-Assessed Vastus Medialis Muscle Fat Content and Risk for Knee Osteoarthritis Progression: Relevance From a Clinical Trial’, Arthritis care & research, 67(10), pp. 1406–1415. doi: 10.1002/acr.22590.
    • Harvard: Australian:
      Raynauld, J-P, Pelletier, J-P, Roubille, C, Dorais, M, Abram, F, Li, W, Wang, Y, Fairley, J, Cicuttini, FM & Martel-Pelletier, J 2015, ‘Magnetic Resonance Imaging-Assessed Vastus Medialis Muscle Fat Content and Risk for Knee Osteoarthritis Progression: Relevance From a Clinical Trial’, Arthritis care & research, vol. 67, no. 10, pp. 1406–1415, viewed 15 August 2020, .
    • MLA:
      Raynauld, Jean-Pierre, et al. “Magnetic Resonance Imaging-Assessed Vastus Medialis Muscle Fat Content and Risk for Knee Osteoarthritis Progression: Relevance From a Clinical Trial.” Arthritis Care & Research, vol. 67, no. 10, Oct. 2015, pp. 1406–1415. EBSCOhost, doi:10.1002/acr.22590.
    • Chicago/Turabian: Humanities:
      Raynauld, Jean-Pierre, Jean-Pierre Pelletier, Camille Roubille, Marc Dorais, François Abram, Wei Li, Yuanyuan Wang, Jessica Fairley, Flavia M Cicuttini, and Johanne Martel-Pelletier. “Magnetic Resonance Imaging-Assessed Vastus Medialis Muscle Fat Content and Risk for Knee Osteoarthritis Progression: Relevance From a Clinical Trial.” Arthritis Care & Research 67, no. 10 (October 2015): 1406–15. doi:10.1002/acr.22590.
    • Vancouver/ICMJE:
      Raynauld J-P, Pelletier J-P, Roubille C, Dorais M, Abram F, Li W, et al. Magnetic Resonance Imaging-Assessed Vastus Medialis Muscle Fat Content and Risk for Knee Osteoarthritis Progression: Relevance From a Clinical Trial. Arthritis care & research [Internet]. 2015 Oct [cited 2020 Aug 15];67(10):1406–15. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=25778112&custid=s8280428