Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Effect of acute hyperinsulinemia on brain metabolism evaluated by 1H MR spectroscopy--a pilot study.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • معلومة اضافية
    • Source:
      Publisher: Published for the Institute of Physiology of the Czechoslovak Academy of Sciences by Academia, Pub. House of the Academy Country of Publication: Czech Republic NLM ID: 9112413 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1802-9973 (Electronic) Linking ISSN: 08628408 NLM ISO Abbreviation: Physiol Res Subsets: MEDLINE
    • Publication Information:
      Original Publication: Praha : Published for the Institute of Physiology of the Czechoslovak Academy of Sciences by Academia, Pub. House of the Academy
    • Subject Terms:
    • Abstract:
      To determine whether acutely-induced supraphysiological hyperinsulinemia influences brain metabolism in patients with type 1 diabetes (D) and healthy controls (C) as detected by MR Spectroscopy. Group D consisted of 4 patients with the average duration of diabetes for 7 years. They were matched according to age, sex and BMI to 4 healthy controls. 1H MR Spectroscopy was performed with a 1.5 Tesla. Spectra were obtained from parietooccipital white matter repeatedly during a 3-h hyperinsulinemic euglycemic clamp with 2 mU.kg(-1).min(-1). In group D, significantly lower basal concentrations of N-acetylaspartate (p=0.02), choline (p=0.03), creatine (p=0.002) and inositol (p=0.007) were detected compared to C. After the induction of hyperinsulinemia, concentrations of choline, creatine, GABA, inositol, lactate, NAA and composite signal glutamate + glutamine (Glx) stayed stable. The detection of glucose signal is less realiable at 1.5 Tesla but we registered the alteration in glucose concentration (p=0.003) in the whole group. Originally sightly elevated glucose concentration in D decreased on the contrary to the increase of originally lower glucose level in C. In conclusions, brain metabolism was altered in D. Short term supraphysiological euglycemic hyperinsulinemia induced changes in the concentration of brain glucose in both C and D.
    • Accession Number:
      0 (Amino Acids)
      0 (Blood Glucose)
    • Publication Date:
      Date Created: 20140408 Date Completed: 20150515 Latest Revision: 20201031
    • Publication Date:
      20210210
    • Accession Number:
      10.33549/physiolres.932505
    • Accession Number:
      24702495