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Haptoglobin Phenotype, Preeclampsia Risk and the Efficacy of Vitamin C and E Supplementation to Prevent Preeclampsia in a Racially Diverse Population.

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  • معلومة اضافية
    • Author-Supplied Keywords:
      Biochemistry
      Biology
      Blood chemistry
      Ethnic differences
      Genetics
      Genetics and Genomics
      Health care policy
      Health risk analysis
      Heredity
      Hypertensive disorders in pregnancy
      Medicine
      Non-clinical medicine
      Obstetrics
      Obstetrics and gynecology
      Phenotypes
      Pregnancy
      Research Article
    • NAICS/Industry Codes:
      325411 Medicinal and Botanical Manufacturing
    • Abstract:
      Haptoglobin’s (Hp) antioxidant and pro-angiogenic properties differ between the 1-1, 2-1, and 2-2 phenotypes. Hp phenotype affects cardiovascular disease risk and treatment response to antioxidant vitamins in some non-pregnant populations. We previously demonstrated that preeclampsia risk was doubled in white Hp 2-1 women, compared to Hp 1-1 women. Our objectives were to determine whether we could reproduce this finding in a larger cohort, and to determine whether Hp phenotype influences lack of efficacy of antioxidant vitamins in preventing preeclampsia and serious complications of pregnancy-associated hypertension (PAH). This is a secondary analysis of a randomized controlled trial in which 10,154 low-risk women received daily vitamin C and E, or placebo, from 9-16 weeks gestation until delivery. Hp phenotype was determined in the study prediction cohort (n = 2,393) and a case-control cohort (703 cases, 1,406 controls). The primary outcome was severe PAH, or mild or severe PAH with elevated liver enzymes, elevated serum creatinine, thrombocytopenia, eclampsia, fetal growth restriction, medically indicated preterm birth or perinatal death. Preeclampsia was a secondary outcome. Odds ratios were estimated by logistic regression. Sampling weights were used to reduce bias from an overrepresentation of women with preeclampsia or the primary outcome. There was no relationship between Hp phenotype and the primary outcome or preeclampsia in Hispanic, white/other or black women. Vitamin supplementation did not reduce the risk of the primary outcome or preeclampsia in women of any phenotype. Supplementation increased preeclampsia risk (odds ratio 3.30; 95% confidence interval 1.61–6.82, p<0.01) in Hispanic Hp 2-2 women. Hp phenotype does not influence preeclampsia risk, or identify a subset of women who may benefit from vitamin C and E supplementation to prevent preeclampsia. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Author Affiliations:
      11 Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States of America
      22 Department of Obstetrics, Gynecology and Reproductive Science, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
      33 The George Washington University Biostatistics Center, Washington, DC, United States of America
      44 The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, United States of America
      5Department of Obstetrics and Gynecology of University of Cincinnati, Cincinnati, Ohio, United States of America
      66 University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
      77 University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
      88 Case Western Reserve University-MetroHealth Medical Center, Cleveland, Ohio, United States of America
      99 Northwestern University, Chicago, Illinois, United States of America
      1010 University of Texas Health Science Center at Houston-Children’s Memorial Hermann Hospital, Houston, Texas, United States of America
      1111 Brown University, Providence, Rhode Island, United States of America
      1212 The Ohio State University, Columbus, Ohio, United States of America
      1313 Drexel University, Philadelphia, Pennsylvania, United States of America
      1414 Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America
      1515 Oregon Health and Science University, Portland, Oregon, United States of America
      1616 University of Texas Medical Branch, Galveston, Texas, United States of America
      1717 Wayne State University, Detroit, Michigan, United States of America
    • ISSN:
      1932-6203
    • Accession Number:
      10.1371/journal.pone.0060479
    • Accession Number:
      87677484
  • Citations
    • ABNT:
      WEISSGERBER, T. L. et al. Haptoglobin Phenotype, Preeclampsia Risk and the Efficacy of Vitamin C and E Supplementation to Prevent Preeclampsia in a Racially Diverse Population. PLoS ONE, [s. l.], v. 8, n. 4, p. 1–9, 2013. DOI 10.1371/journal.pone.0060479. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=87677484&custid=s8280428. Acesso em: 10 ago. 2020.
    • AMA:
      Weissgerber TL, Gandley RE, McGee PL, et al. Haptoglobin Phenotype, Preeclampsia Risk and the Efficacy of Vitamin C and E Supplementation to Prevent Preeclampsia in a Racially Diverse Population. PLoS ONE. 2013;8(4):1-9. doi:10.1371/journal.pone.0060479
    • APA:
      Weissgerber, T. L., Gandley, R. E., McGee, P. L., Spong, C. Y., Myatt, L., Leveno, K. J., Thorp Jr, J. M., Mercer, B. M., Peaceman, A. M., Ramin, S. M., Carpenter, M. W., Samuels, P., Sciscione, A., Harper, M., Tolosa, J. E., Saade, G., & Sorokin, Y. (2013). Haptoglobin Phenotype, Preeclampsia Risk and the Efficacy of Vitamin C and E Supplementation to Prevent Preeclampsia in a Racially Diverse Population. PLoS ONE, 8(4), 1–9. https://doi.org/10.1371/journal.pone.0060479
    • Chicago/Turabian: Author-Date:
      Weissgerber, Tracey L., Robin E. Gandley, Paula L. McGee, Catherine Y. Spong, Leslie Myatt, Kenneth J. Leveno, John M. Thorp Jr, et al. 2013. “Haptoglobin Phenotype, Preeclampsia Risk and the Efficacy of Vitamin C and E Supplementation to Prevent Preeclampsia in a Racially Diverse Population.” PLoS ONE 8 (4): 1–9. doi:10.1371/journal.pone.0060479.
    • Harvard:
      Weissgerber, T. L. et al. (2013) ‘Haptoglobin Phenotype, Preeclampsia Risk and the Efficacy of Vitamin C and E Supplementation to Prevent Preeclampsia in a Racially Diverse Population’, PLoS ONE, 8(4), pp. 1–9. doi: 10.1371/journal.pone.0060479.
    • Harvard: Australian:
      Weissgerber, TL, Gandley, RE, McGee, PL, Spong, CY, Myatt, L, Leveno, KJ, Thorp Jr, JM, Mercer, BM, Peaceman, AM, Ramin, SM, Carpenter, MW, Samuels, P, Sciscione, A, Harper, M, Tolosa, JE, Saade, G & Sorokin, Y 2013, ‘Haptoglobin Phenotype, Preeclampsia Risk and the Efficacy of Vitamin C and E Supplementation to Prevent Preeclampsia in a Racially Diverse Population’, PLoS ONE, vol. 8, no. 4, pp. 1–9, viewed 10 August 2020, .
    • MLA:
      Weissgerber, Tracey L., et al. “Haptoglobin Phenotype, Preeclampsia Risk and the Efficacy of Vitamin C and E Supplementation to Prevent Preeclampsia in a Racially Diverse Population.” PLoS ONE, vol. 8, no. 4, Apr. 2013, pp. 1–9. EBSCOhost, doi:10.1371/journal.pone.0060479.
    • Chicago/Turabian: Humanities:
      Weissgerber, Tracey L., Robin E. Gandley, Paula L. McGee, Catherine Y. Spong, Leslie Myatt, Kenneth J. Leveno, John M. Thorp Jr, et al. “Haptoglobin Phenotype, Preeclampsia Risk and the Efficacy of Vitamin C and E Supplementation to Prevent Preeclampsia in a Racially Diverse Population.” PLoS ONE 8, no. 4 (April 2013): 1–9. doi:10.1371/journal.pone.0060479.
    • Vancouver/ICMJE:
      Weissgerber TL, Gandley RE, McGee PL, Spong CY, Myatt L, Leveno KJ, et al. Haptoglobin Phenotype, Preeclampsia Risk and the Efficacy of Vitamin C and E Supplementation to Prevent Preeclampsia in a Racially Diverse Population. PLoS ONE [Internet]. 2013 Apr [cited 2020 Aug 10];8(4):1–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=87677484&custid=s8280428