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Of Mice, Men and Elephants: The Relation between Articular Cartilage Thickness and Body Mass.

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  • معلومة اضافية
    • Author-Supplied Keywords:
      Anatomy and physiology
      Biochemistry
      Biology
      Bone
      Cartilage
      Cytochemistry
      Extracellular matrix
      Mathematics
      Medicine
      Musculoskeletal system
      Physiology
      Research Article
      Scaling theory
      Statistical theories
      Statistics
    • NAICS/Industry Codes:
      112990 All Other Animal Production
    • Abstract:
      Mammalian articular cartilage serves diverse functions, including shock absorption, force transmission and enabling low-friction joint motion. These challenging requirements are met by the tissue’s thickness combined with its highly specific extracellular matrix, consisting of a glycosaminoglycan-interspersed collagen fiber network that provides a unique combination of resilience and high compressive and shear resistance. It is unknown how this critical tissue deals with the challenges posed by increases in body mass. For this study, osteochondral cores were harvested post-mortem from the central sites of both medial and lateral femoral condyles of 58 different mammalian species ranging from 25 g (mouse) to 4000 kg (African elephant). Joint size and cartilage thickness were measured and biochemical composition (glycosaminoclycan, collagen and DNA content) and collagen cross-links densities were analyzed. Here, we show that cartilage thickness at the femoral condyle in the mammalian species investigated varies between 90 µm and 3000 µm and bears a negative allometric relationship to body mass, unlike the isometric scaling of the skeleton. Cellular density (as determined by DNA content) decreases with increasing body mass, but gross biochemical composition is remarkably constant. This however need not affect life-long performance of the tissue in heavier mammals, due to relatively constant static compressive stresses, the zonal organization of the tissue and additional compensation by joint congruence, posture and activity pattern of larger mammals. These findings provide insight in the scaling of articular cartilage thickness with body weight, as well as in cartilage biochemical composition and cellularity across mammalian species. They underscore the need for the use of appropriate in vivo models in translational research aiming at human applications. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      11 Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands
      22 Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
      33 Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
      44 Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
      55 Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    • ISSN:
      1932-6203
    • Accession Number:
      10.1371/journal.pone.0057683
    • Accession Number:
      87625600
  • Citations
    • ABNT:
      MALDA, J. et al. Of Mice, Men and Elephants: The Relation between Articular Cartilage Thickness and Body Mass. PLoS ONE, [s. l.], v. 8, n. 2, p. 1–8, 2013. DOI 10.1371/journal.pone.0057683. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=87625600&custid=s8280428. Acesso em: 25 maio. 2020.
    • AMA:
      Malda J, de Grauw JC, Benders KEM, et al. Of Mice, Men and Elephants: The Relation between Articular Cartilage Thickness and Body Mass. PLoS ONE. 2013;8(2):1-8. doi:10.1371/journal.pone.0057683.
    • APA:
      Malda, J., de Grauw, J. C., Benders, K. E. M., Kik, M. J. L., van de Lest, C. H. A., Creemers, L. B., Dhert, W. J. A., & van Weeren, P. R. (2013). Of Mice, Men and Elephants: The Relation between Articular Cartilage Thickness and Body Mass. PLoS ONE, 8(2), 1–8. https://doi.org/10.1371/journal.pone.0057683
    • Chicago/Turabian: Author-Date:
      Malda, Jos, Janny C. de Grauw, Kim E. M. Benders, Marja J. L. Kik, Chris H. A. van de Lest, Laura B. Creemers, Wouter J. A. Dhert, and P. René van Weeren. 2013. “Of Mice, Men and Elephants: The Relation between Articular Cartilage Thickness and Body Mass.” PLoS ONE 8 (2): 1–8. doi:10.1371/journal.pone.0057683.
    • Harvard:
      Malda, J. et al. (2013) ‘Of Mice, Men and Elephants: The Relation between Articular Cartilage Thickness and Body Mass’, PLoS ONE, 8(2), pp. 1–8. doi: 10.1371/journal.pone.0057683.
    • Harvard: Australian:
      Malda, J, de Grauw, JC, Benders, KEM, Kik, MJL, van de Lest, CHA, Creemers, LB, Dhert, WJA & van Weeren, PR 2013, ‘Of Mice, Men and Elephants: The Relation between Articular Cartilage Thickness and Body Mass’, PLoS ONE, vol. 8, no. 2, pp. 1–8, viewed 25 May 2020, .
    • MLA:
      Malda, Jos, et al. “Of Mice, Men and Elephants: The Relation between Articular Cartilage Thickness and Body Mass.” PLoS ONE, vol. 8, no. 2, Feb. 2013, pp. 1–8. EBSCOhost, doi:10.1371/journal.pone.0057683.
    • Chicago/Turabian: Humanities:
      Malda, Jos, Janny C. de Grauw, Kim E. M. Benders, Marja J. L. Kik, Chris H. A. van de Lest, Laura B. Creemers, Wouter J. A. Dhert, and P. René van Weeren. “Of Mice, Men and Elephants: The Relation between Articular Cartilage Thickness and Body Mass.” PLoS ONE 8, no. 2 (February 2013): 1–8. doi:10.1371/journal.pone.0057683.
    • Vancouver/ICMJE:
      Malda J, de Grauw JC, Benders KEM, Kik MJL, van de Lest CHA, Creemers LB, et al. Of Mice, Men and Elephants: The Relation between Articular Cartilage Thickness and Body Mass. PLoS ONE [Internet]. 2013 Feb [cited 2020 May 25];8(2):1–8. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=87625600&custid=s8280428