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Tau, where are we now?

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  • معلومة اضافية
    • Abstract:
      Tau is a multifunctional protein that was originally identified as a microtubule-associated protein. Tau is primarily a neuronal protein, but it is becoming increasingly evident that tau is present in non-neuronal cells where it also plays important roles. Tau is the primary protein component of the filaments (both paired helical and straight filaments) found in Alzheimer's disease brain. Further there is an ever growing family of neurodegenerative diseases called "tauopathies" where tau pathology is the primary, defining characteristic with little or no Abeta pathology. These findings, along with the fact that mutations in the tau gene cause a group of diseases collectively known as frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), clearly demonstrate that tau dysfunction results in neuronal dysfunction and death. This review highlights recent findings concerning the normal metabolism and function of tau, as well as the abnormal processing and function of tau in Alzheimer's disease and in the tauopathies, both sporadic and familial. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Journal of Alzheimer's Disease is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • ISSN:
      1387-2877
    • Accession Number:
      10.3233/JAD-2002-4505
    • Accession Number:
      8558926
  • Citations
    • ABNT:
      JOHNSON, G. V. W.; BAILEY, C. D. C. Tau, where are we now? Journal of Alzheimer’s Disease, [s. l.], v. 4, n. 5, p. 375–398, 2002. DOI 10.3233/JAD-2002-4505. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=8558926&custid=s8280428. Acesso em: 4 ago. 2020.
    • AMA:
      Johnson GVW, Bailey CDC. Tau, where are we now? Journal of Alzheimer’s Disease. 2002;4(5):375-398. doi:10.3233/JAD-2002-4505.
    • AMA11:
      Johnson GVW, Bailey CDC. Tau, where are we now? Journal of Alzheimer’s Disease. 2002;4(5):375-398. doi:10.3233/JAD-2002-4505
    • APA:
      Johnson, G. V. W., & Bailey, C. D. C. (2002). Tau, where are we now? Journal of Alzheimer’s Disease, 4(5), 375–398. https://doi.org/10.3233/JAD-2002-4505
    • Chicago/Turabian: Author-Date:
      Johnson, Gail V.W., and Craig D.C. Bailey. 2002. “Tau, Where Are We Now?” Journal of Alzheimer’s Disease 4 (5): 375–98. doi:10.3233/JAD-2002-4505.
    • Harvard:
      Johnson, G. V. W. and Bailey, C. D. C. (2002) ‘Tau, where are we now?’, Journal of Alzheimer’s Disease, 4(5), pp. 375–398. doi: 10.3233/JAD-2002-4505.
    • Harvard: Australian:
      Johnson, GVW & Bailey, CDC 2002, ‘Tau, where are we now?’, Journal of Alzheimer’s Disease, vol. 4, no. 5, pp. 375–398, viewed 4 August 2020, .
    • MLA:
      Johnson, Gail V. W., and Craig D. C. Bailey. “Tau, Where Are We Now?” Journal of Alzheimer’s Disease, vol. 4, no. 5, Oct. 2002, pp. 375–398. EBSCOhost, doi:10.3233/JAD-2002-4505.
    • Chicago/Turabian: Humanities:
      Johnson, Gail V.W., and Craig D.C. Bailey. “Tau, Where Are We Now?” Journal of Alzheimer’s Disease 4, no. 5 (October 2002): 375–98. doi:10.3233/JAD-2002-4505.
    • Vancouver/ICMJE:
      Johnson GVW, Bailey CDC. Tau, where are we now? Journal of Alzheimer’s Disease [Internet]. 2002 Oct [cited 2020 Aug 4];4(5):375–98. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=8558926&custid=s8280428