Gp91phox contributes to the development of experimental inflammatory bowel disease.

Item request has been placed! ×
Item request cannot be made. ×
  Processing Request
  • معلومة اضافية
    • Abstract:
      Inflammatory bowel disease (IBD) is related to dysfunction of intestinal immunity. Neutrophils have an important role in innate immunity via the oxidative burst, using the p47phox- and gp91phox-containing NAD(P)H oxidase known as Nox2. In dextran sulphate sodium (DSS)-induced colitis, no significant difference in inflammation between p47phox−/− and wild-type (WT) mice was reported, but there was improved endothelium-dependent arteriolar dilation in gp91phox−/− mice, compared with that in WT mice. Gp91phox and p47 phox are not only essential components of phagocyte Nox2, but also have roles in other enzymes. Thus the differences in response of their respective gene knockout mice to DSS challenge are not completely unexpected, but need further investigation. The clinicopathological changes and immunological responses to DSS challenge have not been fully described in gp91phox−/− mice. Thus we treated WT and gp91phox−/− mice with 2.5% DSS for 7 days. The gp91phox−/− mice developed less severe colitis than WT mice following DSS treatment, reflected by a smaller body weight loss, less rectal bleeding and fewer histopathological changes. Less colonic myeloperoxidase was observed in gp91phox−/−, compared with WT mice, following DSS challenge, correlating with interleukin (IL)-6 production. IL-10 was upregulated in both gp91phox−/− and WT mice, but was significantly higher in the latter, following 7 days DSS challenge. These results suggest that gp91phox−/− mice are less susceptible to acute DSS-induced colitis, possibly because of a reduced oxidative burst in the intestine and, consequently, less tissue damage. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Immunology & Cell Biology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1Discipline of Pathology, Bosch Institute and School of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia
    • ISSN:
      0818-9641
    • Accession Number:
      10.1038/icb.2011.4
    • Accession Number:
      67115275
  • Citations
    • ABNT:
      BAO, S. et al. Gp91phox contributes to the development of experimental inflammatory bowel disease. Immunology & Cell Biology, [s. l.], v. 89, n. 8, p. 853–860, 2011. DOI 10.1038/icb.2011.4. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=67115275&custid=s8280428. Acesso em: 27 jan. 2020.
    • AMA:
      Bao S, Carr ED, Xu Y-H, Hunt NH. Gp91phox contributes to the development of experimental inflammatory bowel disease. Immunology & Cell Biology. 2011;89(8):853-860. doi:10.1038/icb.2011.4.
    • APA:
      Bao, S., Carr, E. D., Xu, Y.-H., & Hunt, N. H. (2011). Gp91phox contributes to the development of experimental inflammatory bowel disease. Immunology & Cell Biology, 89(8), 853–860. https://doi.org/10.1038/icb.2011.4
    • Chicago/Turabian: Author-Date:
      Bao, Shisan, Emma DJ Carr, Ying-Hua Xu, and Nicholas H Hunt. 2011. “Gp91phox Contributes to the Development of Experimental Inflammatory Bowel Disease.” Immunology & Cell Biology 89 (8): 853–60. doi:10.1038/icb.2011.4.
    • Harvard:
      Bao, S. et al. (2011) ‘Gp91phox contributes to the development of experimental inflammatory bowel disease’, Immunology & Cell Biology, 89(8), pp. 853–860. doi: 10.1038/icb.2011.4.
    • Harvard: Australian:
      Bao, S, Carr, ED, Xu, Y-H & Hunt, NH 2011, ‘Gp91phox contributes to the development of experimental inflammatory bowel disease’, Immunology & Cell Biology, vol. 89, no. 8, pp. 853–860, viewed 27 January 2020, .
    • MLA:
      Bao, Shisan, et al. “Gp91phox Contributes to the Development of Experimental Inflammatory Bowel Disease.” Immunology & Cell Biology, vol. 89, no. 8, Nov. 2011, pp. 853–860. EBSCOhost, doi:10.1038/icb.2011.4.
    • Chicago/Turabian: Humanities:
      Bao, Shisan, Emma DJ Carr, Ying-Hua Xu, and Nicholas H Hunt. “Gp91phox Contributes to the Development of Experimental Inflammatory Bowel Disease.” Immunology & Cell Biology 89, no. 8 (November 2011): 853–60. doi:10.1038/icb.2011.4.
    • Vancouver/ICMJE:
      Bao S, Carr ED, Xu Y-H, Hunt NH. Gp91phox contributes to the development of experimental inflammatory bowel disease. Immunology & Cell Biology [Internet]. 2011 Nov [cited 2020 Jan 27];89(8):853–60. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=67115275&custid=s8280428