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Role of the vascular and lymphatic endothelium in the pathogenesis of inflammatory bowel disease: 'brothers in arms'.

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  • معلومة اضافية
    • Abstract:
      The 'IN' of chronic inflammationdthat is, the mechanisms of cell entry into the intestinal mucosa, bacterial and foreign antigen invasion, angiogenesis, and the control of gut inflammation through intestinal microvasculaturedhas received a great deal of attention in studies of the pathogenesis of inflammatory bowel disease (IBD). This has resulted in the validation of several targets for the treatment of experimental inflammationdboth on immune and non-immune cellsdsome of which have translated into effective treatments for patients with IBD. An important aspect of this has been our growing understanding of the role the intestinal vascular microcirculation plays in the initiation and perpetuation of the inflammatory process, by regulating the migration of leucocytes into the interstitial space. However, it is becoming increasingly clear that it is also important to focus on the 'OUT' of chronic inflammationdthat is, the lymphatics and their role in controlling tissue oedema, leucocyte exit, bacterial antigen and inflammatory chemokine clearance. As our understanding of the lymphatics and the role they play grows, another rich source of non-immune cell targets for therapeutic intervention is gradually being revealed. This article describes current knowledge of the roles played by the vascular and lymphatic endothelium throughout the gut in the pathogenesis of IBD, and how this differs from their role under physiological conditions, as well as discussing current and future therapeutic targets that have been identified. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Author Affiliations:
      1Division of Gastroenterology, IRCCS Istituto Clinico Humanitas, Via Manzoni 56, 20089, Rozzano, Milan, Italy
    • ISSN:
      0017-5749
    • Accession Number:
      10.1136/gut.2010.207480
    • Accession Number:
      64735914
  • Citations
    • ABNT:
      DANESE, S. Role of the vascular and lymphatic endothelium in the pathogenesis of inflammatory bowel disease: “brothers in arms”. Gut, [s. l.], v. 60, n. 7, p. 998–1008, 2011. DOI 10.1136/gut.2010.207480. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=64735914&custid=s8280428. Acesso em: 25 maio. 2020.
    • AMA:
      Danese S. Role of the vascular and lymphatic endothelium in the pathogenesis of inflammatory bowel disease: “brothers in arms.” Gut. 2011;60(7):998-1008. doi:10.1136/gut.2010.207480.
    • APA:
      Danese, S. (2011). Role of the vascular and lymphatic endothelium in the pathogenesis of inflammatory bowel disease: “brothers in arms.” Gut, 60(7), 998–1008. https://doi.org/10.1136/gut.2010.207480
    • Chicago/Turabian: Author-Date:
      Danese, Silvio. 2011. “Role of the Vascular and Lymphatic Endothelium in the Pathogenesis of Inflammatory Bowel Disease: ‘Brothers in Arms.’” Gut 60 (7): 998–1008. doi:10.1136/gut.2010.207480.
    • Harvard:
      Danese, S. (2011) ‘Role of the vascular and lymphatic endothelium in the pathogenesis of inflammatory bowel disease: “brothers in arms”’, Gut, 60(7), pp. 998–1008. doi: 10.1136/gut.2010.207480.
    • Harvard: Australian:
      Danese, S 2011, ‘Role of the vascular and lymphatic endothelium in the pathogenesis of inflammatory bowel disease: “brothers in arms”’, Gut, vol. 60, no. 7, pp. 998–1008, viewed 25 May 2020, .
    • MLA:
      Danese, Silvio. “Role of the Vascular and Lymphatic Endothelium in the Pathogenesis of Inflammatory Bowel Disease: ‘Brothers in Arms.’” Gut, vol. 60, no. 7, July 2011, pp. 998–1008. EBSCOhost, doi:10.1136/gut.2010.207480.
    • Chicago/Turabian: Humanities:
      Danese, Silvio. “Role of the Vascular and Lymphatic Endothelium in the Pathogenesis of Inflammatory Bowel Disease: ‘Brothers in Arms.’” Gut 60, no. 7 (July 2011): 998–1008. doi:10.1136/gut.2010.207480.
    • Vancouver/ICMJE:
      Danese S. Role of the vascular and lymphatic endothelium in the pathogenesis of inflammatory bowel disease: “brothers in arms.” Gut [Internet]. 2011 Jul [cited 2020 May 25];60(7):998–1008. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=64735914&custid=s8280428