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Impact of simulated microgravity on microvascular endothelial cell apoptosis.

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  • معلومة اضافية
    • Author-Supplied Keywords:
      Apoptosis
      Endothelial cell
      Microgravity
      Microvascular
      PI3K/Akt pathway
    • Abstract:
      Cardiovascular deconditioning is known to occur in astronauts exposed to microgravity. Endothelial dysfunction at microcirculatory sites might contribute to cardiovascular deconditioning induced by weightlessness. Recent studies have reported changes in the morphology and gene expression of endothelial cells exposed to conditions of simulated microgravity. The present study was aimed at examining the effects of microgravity on the apoptosis of microvascular endothelial cells and the mechanism underlying these effects. We simulated a microgravity environment and found that microgravity induced microvascular endothelial cell apoptosis and that this effect was correlated with the downregulation of the PI3K/Akt pathway, increased expression of NF-κB, and depolymerization of F-actin. These findings may provide important insights into the origin of the adverse physiological changes occurring due to exposure to microgravity conditions. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of European Journal of Applied Physiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1Nanlou Respiratory Diseases Department, Chinese PLA General Hospital, Beijing 100853 People's Republic of China
      2The State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing 100094 People's Republic of China
      3Department of Respiratory Diseases, Affiliated Hospital of the Academy of Military Medical Science, Beijing 100071 People's Republic of China
      4Exclusive Medical Care Centre, General Hospital of Chinese People of Armed Police Forces, Beijing 100039 People's Republic of China
      5Nanlou Respiratory Diseases Department, Chinese PLA General Hospital, Beijing 100853, People's Republic of China
    • ISSN:
      1439-6319
    • Accession Number:
      10.1007/s00421-011-1844-0
    • Accession Number:
      64301516
  • Citations
    • ABNT:
      CHUN-YAN KANG et al. Impact of simulated microgravity on microvascular endothelial cell apoptosis. European Journal of Applied Physiology, [s. l.], v. 111, n. 9, p. 2131–2138, 2011. DOI 10.1007/s00421-011-1844-0. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=64301516&custid=s8280428. Acesso em: 24 maio. 2020.
    • AMA:
      Chun-Yan Kang, Lin Zou, Ming Yuan, et al. Impact of simulated microgravity on microvascular endothelial cell apoptosis. European Journal of Applied Physiology. 2011;111(9):2131-2138. doi:10.1007/s00421-011-1844-0.
    • APA:
      Chun-Yan Kang, Lin Zou, Ming Yuan, Yang Wang, Tian-Zhi Li, Ye Zhang, Jun-Feng Wang, Yan Li, Xiao-Wei Deng, Chang-Ting Liu, Kang, C.-Y., Zou, L., Yuan, M., Wang, Y., Li, T.-Z., Zhang, Y., Wang, J.-F., Li, Y., Deng, X.-W., & Liu, C.-T. (2011). Impact of simulated microgravity on microvascular endothelial cell apoptosis. European Journal of Applied Physiology, 111(9), 2131–2138. https://doi.org/10.1007/s00421-011-1844-0
    • Chicago/Turabian: Author-Date:
      Chun-Yan Kang, Lin Zou, Ming Yuan, Yang Wang, Tian-Zhi Li, Ye Zhang, Jun-Feng Wang, et al. 2011. “Impact of Simulated Microgravity on Microvascular Endothelial Cell Apoptosis.” European Journal of Applied Physiology 111 (9): 2131–38. doi:10.1007/s00421-011-1844-0.
    • Harvard:
      Chun-Yan Kang et al. (2011) ‘Impact of simulated microgravity on microvascular endothelial cell apoptosis’, European Journal of Applied Physiology, 111(9), pp. 2131–2138. doi: 10.1007/s00421-011-1844-0.
    • Harvard: Australian:
      Chun-Yan Kang, Lin Zou, Ming Yuan, Yang Wang, Tian-Zhi Li, Ye Zhang, Jun-Feng Wang, Yan Li, Xiao-Wei Deng, Chang-Ting Liu, Kang, C-Y, Zou, L, Yuan, M, Wang, Y, Li, T-Z, Zhang, Y, Wang, J-F, Li, Y, Deng, X-W & Liu, C-T 2011, ‘Impact of simulated microgravity on microvascular endothelial cell apoptosis’, European Journal of Applied Physiology, vol. 111, no. 9, pp. 2131–2138, viewed 24 May 2020, .
    • MLA:
      Chun-Yan Kang, et al. “Impact of Simulated Microgravity on Microvascular Endothelial Cell Apoptosis.” European Journal of Applied Physiology, vol. 111, no. 9, Aug. 2011, pp. 2131–2138. EBSCOhost, doi:10.1007/s00421-011-1844-0.
    • Chicago/Turabian: Humanities:
      Chun-Yan Kang, Lin Zou, Ming Yuan, Yang Wang, Tian-Zhi Li, Ye Zhang, Jun-Feng Wang, et al. “Impact of Simulated Microgravity on Microvascular Endothelial Cell Apoptosis.” European Journal of Applied Physiology 111, no. 9 (August 2011): 2131–38. doi:10.1007/s00421-011-1844-0.
    • Vancouver/ICMJE:
      Chun-Yan Kang, Lin Zou, Ming Yuan, Yang Wang, Tian-Zhi Li, Ye Zhang, et al. Impact of simulated microgravity on microvascular endothelial cell apoptosis. European Journal of Applied Physiology [Internet]. 2011 Aug [cited 2020 May 24];111(9):2131–8. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=64301516&custid=s8280428