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Tau Protein in Normal and Alzheimer's Disease Brain: An Update.

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  • معلومة اضافية
    • Abstract:
      Tau is a microtubule-associated protein that, in a hyperphosphorylated form, comprises the main component of the paired helical filaments and neurofibrillary tangles found in Alzheimer's Disease (AD) brain.  It is therefore important to understand the normal functioning and processing of tau protein, and the abnormal posttranslational processing of tau in AD pathology.  In 1996, Johnson and Jenkins reviewed the literature on the biochemistry, function, and phos-phorylation of tau in normal and AD brain.  Since that time, numerous publications have come out further elucidating the properties of tau.  The present review updates the topics originally covered in the 1996 review, as well as presents a number of new topics. For example, mutations in the tau gene have been found in several non-AD, autosomal dominant neurodegenerative disorders that exhibit extensive neurofibrillary pathology.  In addition, there is increasing evidence that tau may be involved in signal transduction, organelle transport, and cell growth, independent of its microtubule-binding functions. Taken together, the research reviewed here demonstrates that tau is a very complex protein with various functions that are intricately regulated.  It is clear that more research is required to completely understand the functions and regulation of tau in normal and AD brain. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Journal of Alzheimer's Disease is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • ISSN:
      1387-2877
    • Accession Number:
      10.3233/JAD-1999-14-512
    • Accession Number:
      4832878
  • Citations
    • ABNT:
      JOHNSON, G. V. W.; HARTIGAN, J. A. Tau Protein in Normal and Alzheimer’s Disease Brain: An Update. Journal of Alzheimer’s Disease, [s. l.], v. 1, n. 4/5, p. 329, 1999. DOI 10.3233/JAD-1999-14-512. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=4832878&custid=s8280428. Acesso em: 13 ago. 2020.
    • AMA:
      Johnson GVW, Hartigan JA. Tau Protein in Normal and Alzheimer’s Disease Brain: An Update. Journal of Alzheimer’s Disease. 1999;1(4/5):329. doi:10.3233/JAD-1999-14-512
    • APA:
      Johnson, G. V. W., & Hartigan, J. A. (1999). Tau Protein in Normal and Alzheimer’s Disease Brain: An Update. Journal of Alzheimer’s Disease, 1(4/5), 329. https://doi.org/10.3233/JAD-1999-14-512
    • Chicago/Turabian: Author-Date:
      Johnson, Gail V.W., and Judith A. Hartigan. 1999. “Tau Protein in Normal and Alzheimer’s Disease Brain: An Update.” Journal of Alzheimer’s Disease 1 (4/5): 329. doi:10.3233/JAD-1999-14-512.
    • Harvard:
      Johnson, G. V. W. and Hartigan, J. A. (1999) ‘Tau Protein in Normal and Alzheimer’s Disease Brain: An Update’, Journal of Alzheimer’s Disease, 1(4/5), p. 329. doi: 10.3233/JAD-1999-14-512.
    • Harvard: Australian:
      Johnson, GVW & Hartigan, JA 1999, ‘Tau Protein in Normal and Alzheimer’s Disease Brain: An Update’, Journal of Alzheimer’s Disease, vol. 1, no. 4/5, p. 329, viewed 13 August 2020, .
    • MLA:
      Johnson, Gail V. W., and Judith A. Hartigan. “Tau Protein in Normal and Alzheimer’s Disease Brain: An Update.” Journal of Alzheimer’s Disease, vol. 1, no. 4/5, Nov. 1999, p. 329. EBSCOhost, doi:10.3233/JAD-1999-14-512.
    • Chicago/Turabian: Humanities:
      Johnson, Gail V.W., and Judith A. Hartigan. “Tau Protein in Normal and Alzheimer’s Disease Brain: An Update.” Journal of Alzheimer’s Disease 1, no. 4/5 (November 1999): 329. doi:10.3233/JAD-1999-14-512.
    • Vancouver/ICMJE:
      Johnson GVW, Hartigan JA. Tau Protein in Normal and Alzheimer’s Disease Brain: An Update. Journal of Alzheimer’s Disease [Internet]. 1999 Nov [cited 2020 Aug 13];1(4/5):329. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=4832878&custid=s8280428