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The Last Tangle of Tau.

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  • معلومة اضافية
    • Author-Supplied Keywords:
      Alzheimer's disease
      intermediate tau aggregates
      neurotoxicity
      tangles
      tauopathy
    • Abstract:
      Tau aggregates into neurofibrillary tangles in Alzheimer's disease and tauopathies. There is ongoing debate about whether tau aggregation is toxic and which form of tau is toxic. Based on recent studies showing that mature tau tangles can be dissociated from neuronal loss and cognitive deficits, it can be hypothesized that the intermediate pre-fibrillar tau aggregate is the predominant neurotoxic tau species. The toxicity of tau aggregation includes loss of physiological functions of native tau and gain of pathological functions of pre-fibrillar tau species. Mature tau tangles per se might be relatively inert or even represent failed cytoprotective efforts of protein quality control machineries in response to accumulating toxic tau species. Further studies on the mechanisms of tau aggregation, the structure of intermediate tau forms and their toxicity are needed to settle this debate. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Journal of Alzheimer's Disease is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL, USA
      2Department of Anesthesiology, University of Rochester Medical Center, Rochester, NY, USA
    • ISSN:
      1387-2877
    • Accession Number:
      10.3233/JAD-2008-14413
    • Accession Number:
      33410213
  • Citations
    • ABNT:
      HUIPING DING; JOHNSON, G. V. W. The Last Tangle of Tau. Journal of Alzheimer’s Disease, [s. l.], v. 14, n. 4, p. 441–447, 2008. DOI 10.3233/JAD-2008-14413. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=33410213&custid=s8280428. Acesso em: 4 ago. 2020.
    • AMA:
      Huiping Ding, Johnson GVW. The Last Tangle of Tau. Journal of Alzheimer’s Disease. 2008;14(4):441-447. doi:10.3233/JAD-2008-14413.
    • AMA11:
      Huiping Ding, Johnson GVW. The Last Tangle of Tau. Journal of Alzheimer’s Disease. 2008;14(4):441-447. doi:10.3233/JAD-2008-14413
    • APA:
      Huiping Ding, & Johnson, G. V. W. (2008). The Last Tangle of Tau. Journal of Alzheimer’s Disease, 14(4), 441–447. https://doi.org/10.3233/JAD-2008-14413
    • Chicago/Turabian: Author-Date:
      Huiping Ding, and Gail V. W. Johnson. 2008. “The Last Tangle of Tau.” Journal of Alzheimer’s Disease 14 (4): 441–47. doi:10.3233/JAD-2008-14413.
    • Harvard:
      Huiping Ding and Johnson, G. V. W. (2008) ‘The Last Tangle of Tau’, Journal of Alzheimer’s Disease, 14(4), pp. 441–447. doi: 10.3233/JAD-2008-14413.
    • Harvard: Australian:
      Huiping Ding & Johnson, GVW 2008, ‘The Last Tangle of Tau’, Journal of Alzheimer’s Disease, vol. 14, no. 4, pp. 441–447, viewed 4 August 2020, .
    • MLA:
      Huiping Ding, and Gail V. W. Johnson. “The Last Tangle of Tau.” Journal of Alzheimer’s Disease, vol. 14, no. 4, Aug. 2008, pp. 441–447. EBSCOhost, doi:10.3233/JAD-2008-14413.
    • Chicago/Turabian: Humanities:
      Huiping Ding, and Gail V. W. Johnson. “The Last Tangle of Tau.” Journal of Alzheimer’s Disease 14, no. 4 (August 2008): 441–47. doi:10.3233/JAD-2008-14413.
    • Vancouver/ICMJE:
      Huiping Ding, Johnson GVW. The Last Tangle of Tau. Journal of Alzheimer’s Disease [Internet]. 2008 Aug [cited 2020 Aug 4];14(4):441–7. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=33410213&custid=s8280428