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Cyproheptadine resembles clozapine in rive following both acute and chronic administration in rats.

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  • معلومة اضافية
    • Author-Supplied Keywords:
      antipsychotic
      chlordiazepoxide
      clozapine
      cyproheptadine
      drug discrimination
      movement disorders
      rats
      weight gain
      withdrawal
    • NAICS/Industry Codes:
      325411 Medicinal and Botanical Manufacturing
      325410 Pharmaceutical and medicine manufacturing
      112990 All Other Animal Production
    • Abstract:
      Cyproheptadine is a cheap, widely available anti-allergy drug with a broad receptor binding profile which resembles that of clozapine. In rats discriminating clozapine from vehicle cyproheptadine mimicked clozapine very closely. Acutely it induced full generalization in the absence of response suppression, as observed with clozapine. Chronic administration of clozapine and cyproheptadine induced tolerance and cross-tolerance respectively to the clozapine stimulus. This was characterized by circa 3.5-fold parallel shifts to the right in the clozapine generalization curves. Such tolerance and cross-tolerance was spontaneously reversible, suggesting that it was pharmacodynamic, and that clozapine and cyproheptadine induce similar neuroadaptations when administered chronically. Administration of chtordiazepoxide at a very high dose induced no cross-tolerance to the clozapine stimulus showing the pharmacological specificity of tolerance. The clozapine stimulus is a compound cue involving actions at various receptors, and various clozapine-like antipsychotic (APD) drugs generalize fully to it. These data demonstrate that in vivo cyproheptadine resembles clozapine both acutely and chronically. Our findings, in conjunction with other actions of cyproheptadine -- induction of weight gain, alleviation of clozapine withdrawal, anxiolytic actions, alleviation of 'typical' APD-induced motoric side effects, and some preliminary clinical findings -- suggest that further study of cyproheptadine in conjunction with a 'typical' APD for the possible treatment of schizophrenia is merited at both pre-clinical and clinical levels. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Journal of Psychopharmacology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1School of Psychology, Liverpool University, Liverpool, UK
      2Centre for Public Health, Liverpool John Moores University, Liverpool, UK
    • ISSN:
      0269-8811
    • Accession Number:
      10.1177/0269881107067076
    • Accession Number:
      24682976
  • Citations
    • ABNT:
      GOUDIE, A. J. et al. Cyproheptadine resembles clozapine in rive following both acute and chronic administration in rats. Journal of Psychopharmacology, [s. l.], v. 21, n. 2, p. 179–190, 2007. DOI 10.1177/0269881107067076. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=24682976&custid=s8280428. Acesso em: 11 ago. 2020.
    • AMA:
      Goudie AJ, Cooper GD, Cole JC, Sumnall HR. Cyproheptadine resembles clozapine in rive following both acute and chronic administration in rats. Journal of Psychopharmacology. 2007;21(2):179-190. doi:10.1177/0269881107067076
    • APA:
      Goudie, A. J., Cooper, G. D., Cole, J. C., & Sumnall, H. R. (2007). Cyproheptadine resembles clozapine in rive following both acute and chronic administration in rats. Journal of Psychopharmacology, 21(2), 179–190. https://doi.org/10.1177/0269881107067076
    • Chicago/Turabian: Author-Date:
      Goudie, Andrew J., Gillian D. Cooper, Jan C. Cole, and Harry R. Sumnall. 2007. “Cyproheptadine Resembles Clozapine in Rive Following Both Acute and Chronic Administration in Rats.” Journal of Psychopharmacology 21 (2): 179–90. doi:10.1177/0269881107067076.
    • Harvard:
      Goudie, A. J. et al. (2007) ‘Cyproheptadine resembles clozapine in rive following both acute and chronic administration in rats’, Journal of Psychopharmacology, 21(2), pp. 179–190. doi: 10.1177/0269881107067076.
    • Harvard: Australian:
      Goudie, AJ, Cooper, GD, Cole, JC & Sumnall, HR 2007, ‘Cyproheptadine resembles clozapine in rive following both acute and chronic administration in rats’, Journal of Psychopharmacology, vol. 21, no. 2, pp. 179–190, viewed 11 August 2020, .
    • MLA:
      Goudie, Andrew J., et al. “Cyproheptadine Resembles Clozapine in Rive Following Both Acute and Chronic Administration in Rats.” Journal of Psychopharmacology, vol. 21, no. 2, Mar. 2007, pp. 179–190. EBSCOhost, doi:10.1177/0269881107067076.
    • Chicago/Turabian: Humanities:
      Goudie, Andrew J., Gillian D. Cooper, Jan C. Cole, and Harry R. Sumnall. “Cyproheptadine Resembles Clozapine in Rive Following Both Acute and Chronic Administration in Rats.” Journal of Psychopharmacology 21, no. 2 (March 2007): 179–90. doi:10.1177/0269881107067076.
    • Vancouver/ICMJE:
      Goudie AJ, Cooper GD, Cole JC, Sumnall HR. Cyproheptadine resembles clozapine in rive following both acute and chronic administration in rats. Journal of Psychopharmacology [Internet]. 2007 Mar [cited 2020 Aug 11];21(2):179–90. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=24682976&custid=s8280428