Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Functional and Structural Adaptations of Skeletal Muscle in Long‐Term Juvenile Dermatomyositis: A Controlled Cross‐Sectional Study.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • معلومة اضافية
    • NAICS/Industry Codes:
      621512 Diagnostic Imaging Centers
      713940 Fitness and Recreational Sports Centers
    • Abstract:
      Objective: To compare muscle strength and endurance of the knee extensors between patients with long‐term juvenile dermatomyositis (DM) and controls and between patients with active disease and those with inactive disease, and to explore associations between strength/endurance and 1) clinical parameters, 2) physical activity, and 3) humoral/structural adaptation in the skeletal muscle of patients. Methods: In a cross‐sectional study (44 patients and 44 age‐ and sex‐matched controls), we tested isometric muscle strength (peak torque, in Nm) and dynamic muscle endurance (total work, in Joules) of the knee extensors, physical activity (measured by accelerometer), and serum myokine levels (by enzyme‐linked immunosorbent assay). Patients were examined with validated tools (clinical muscle tests and measures of disease activity/damage and inactive disease) and using magnetic resonance imaging of the thigh muscles, which included evaluation of the quadriceps cross‐sectional area (CSA). Needle biopsy samples of the vastus lateralis muscle (obtained from 12 patients ages ≥18 years) were assessed by histochemistry. Results: After a mean ± SD disease duration of 21.8 ± 11.8 years, peak torque was lower in patients with juvenile DM compared to controls (mean difference 29 Nm, 95% confidence interval 13–46; P = 0.001). Similarly, total work of the knee extensors was lower in patients compared to controls (median 738J [interquartile range 565–1,155] versus 1,249J [interquartile range 815–1,665]; P < 0.001). Both peak torque and total work were lower in patients with active juvenile DM compared to those with inactive disease (both P < 0.019); in analyses controlled for quadriceps CSA, only total work remained lower in patients with active disease. Moreover, peak torque and total work correlated with findings from clinical muscle tests in patients with active disease (r = 0.57–0.84). Muscle biopsy results indicated that the fiber type composition was different, but capillary density was similar, between patients with active disease and those with inactive disease. Conclusion: In patients with long‐term juvenile DM, both muscle strength and endurance of the knee extensors were lower when compared to matched controls, and also lower in patients with active disease compared to those with inactive disease. Our results indicate a need for more sensitive muscle tests in this clinical setting. We hypothesize that impaired muscle endurance in patients with active juvenile DM may be influenced by structural/functional adaptations of muscle tissue independent of muscle size. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Arthritis & Rheumatology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1Oslo University Hospital, Rikshospitalet Oslo,, Norway
      2Norwegian School of Sport Sciences, Oslo, Norway
      3Oslo University Hospital and University of Oslo, Oslo, Norway
      4Norwegian National Advisory Unit on Rheumatic Diseases in Children and Adolescents, Oslo University Hospital, Rikshospitalet, and Bjørknes University College, Oslo, Norway
    • ISSN:
      2326-5191
    • Accession Number:
      10.1002/art.41174
    • Accession Number:
      142926917
  • Citations
    • ABNT:
      BERNTSEN, K. S. et al. Functional and Structural Adaptations of Skeletal Muscle in Long‐Term Juvenile Dermatomyositis: A Controlled Cross‐Sectional Study. Arthritis & Rheumatology, [s. l.], v. 72, n. 5, p. 837–848, 2020. DOI 10.1002/art.41174. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=142926917&custid=s8280428. Acesso em: 10 jul. 2020.
    • AMA:
      Berntsen KS, Raastad T, Marstein H, et al. Functional and Structural Adaptations of Skeletal Muscle in Long‐Term Juvenile Dermatomyositis: A Controlled Cross‐Sectional Study. Arthritis & Rheumatology. 2020;72(5):837-848. doi:10.1002/art.41174.
    • AMA11:
      Berntsen KS, Raastad T, Marstein H, et al. Functional and Structural Adaptations of Skeletal Muscle in Long‐Term Juvenile Dermatomyositis: A Controlled Cross‐Sectional Study. Arthritis & Rheumatology. 2020;72(5):837-848. doi:10.1002/art.41174
    • APA:
      Berntsen, K. S., Raastad, T., Marstein, H., Kirkhus, E., Merckoll, E., Cumming, K. T., Flatø, B., Sjaastad, I., & Sanner, H. (2020). Functional and Structural Adaptations of Skeletal Muscle in Long‐Term Juvenile Dermatomyositis: A Controlled Cross‐Sectional Study. Arthritis & Rheumatology, 72(5), 837–848. https://doi.org/10.1002/art.41174
    • Chicago/Turabian: Author-Date:
      Berntsen, Kristin Schjander, Truls Raastad, Henriette Marstein, Eva Kirkhus, Else Merckoll, Kristoffer Toldnes Cumming, Berit Flatø, Ivar Sjaastad, and Helga Sanner. 2020. “Functional and Structural Adaptations of Skeletal Muscle in Long‐Term Juvenile Dermatomyositis: A Controlled Cross‐Sectional Study.” Arthritis & Rheumatology 72 (5): 837–48. doi:10.1002/art.41174.
    • Harvard:
      Berntsen, K. S. et al. (2020) ‘Functional and Structural Adaptations of Skeletal Muscle in Long‐Term Juvenile Dermatomyositis: A Controlled Cross‐Sectional Study’, Arthritis & Rheumatology, 72(5), pp. 837–848. doi: 10.1002/art.41174.
    • Harvard: Australian:
      Berntsen, KS, Raastad, T, Marstein, H, Kirkhus, E, Merckoll, E, Cumming, KT, Flatø, B, Sjaastad, I & Sanner, H 2020, ‘Functional and Structural Adaptations of Skeletal Muscle in Long‐Term Juvenile Dermatomyositis: A Controlled Cross‐Sectional Study’, Arthritis & Rheumatology, vol. 72, no. 5, pp. 837–848, viewed 10 July 2020, .
    • MLA:
      Berntsen, Kristin Schjander, et al. “Functional and Structural Adaptations of Skeletal Muscle in Long‐Term Juvenile Dermatomyositis: A Controlled Cross‐Sectional Study.” Arthritis & Rheumatology, vol. 72, no. 5, May 2020, pp. 837–848. EBSCOhost, doi:10.1002/art.41174.
    • Chicago/Turabian: Humanities:
      Berntsen, Kristin Schjander, Truls Raastad, Henriette Marstein, Eva Kirkhus, Else Merckoll, Kristoffer Toldnes Cumming, Berit Flatø, Ivar Sjaastad, and Helga Sanner. “Functional and Structural Adaptations of Skeletal Muscle in Long‐Term Juvenile Dermatomyositis: A Controlled Cross‐Sectional Study.” Arthritis & Rheumatology 72, no. 5 (May 2020): 837–48. doi:10.1002/art.41174.
    • Vancouver/ICMJE:
      Berntsen KS, Raastad T, Marstein H, Kirkhus E, Merckoll E, Cumming KT, et al. Functional and Structural Adaptations of Skeletal Muscle in Long‐Term Juvenile Dermatomyositis: A Controlled Cross‐Sectional Study. Arthritis & Rheumatology [Internet]. 2020 May [cited 2020 Jul 10];72(5):837–48. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=142926917&custid=s8280428