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The effect of interleukin-8 in the early stage after anterior cruciate ligament reconstruction with remnant preservation.

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  • معلومة اضافية
    • Author-Supplied Keywords:
      Angiogenesis
      Anterior cruciate ligament reconstruction
      Interleukin-8
      Joint fluid
      Remnant preservation
    • NAICS/Industry Codes:
      621512 Diagnostic Imaging Centers
    • Abstract:
      Purpose: We studied the effect of interleukin-8 (IL-8) as the factor for angiogenesis in the joint fluid of remnant-preserved anterior cruciate ligament reconstruction (RP-ACLR). Materials and methods: We measured 12 cytokines in joint fluid by multiplex assay and assessed the relationship between IL-8 and vascular endothelial growth factor (VEGF) concentrations. The signal intensity and mean sagittal diameter via postoperative magnetic resonance imaging (MRI) scans were evaluated and the stress X-ray image was analyzed at 3, 6, and 12 months after operation. Results: The IL-8 concentration was highest 3 months postoperatively in those patients who underwent RP-ACLR. Clinical data also showed that the signal intensity and stress radiography of the knee graft were significantly better at the early postoperative stage. Discussion: Our results show that IL-8 plays an important role in angiogenesis within 3 months after RP-ACLR. This effect yields better recovery after operation. RP-ACLR patients with high knee stability in clinical data were identical to those with high expression of IL-8 in experimental data. Therefore, IL-8 has been shown to help revascularization and ligamentization of the grafted tendon. These results indicate that IL-8 in RP-ACLR is an important factor for angiogenesis after operation. Unfortunately, the relationship of IL-8 and VEGF in vivo has not been studied. Conclusion: Our results showed that the IL-8 concentration was very high within 3 months after RP-ACLR operation. The increase in concentration of IL-8 over time was consistent with the increase in VEGF concentration. In the IL-8 clinical setting, MRI analysis showed that ACL synovialization and tension were better in patients who underwent the remnant preservation method. In addition, it was shown that RP-ACLR may be advantageous for early anterior stability within 1 year post operation and beneficial for tendon graft in the early stage post operation. Taken together, our findings suggest that IL-8 may contribute to angiogenesis which is helpful for revascularization and ligamentization of the graft tendon in the early stages of RP-ACLR. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Author Affiliations:
      1Gachon Medical Research Institute, Gil Medical Center, Gachon University, 38-13 Dokjeom-ro 3beon-gil, Namdong-gu, 21565, Incheon, Republic of Korea
      2Department of Orthopaedic Surgery, Gil Medical Center, Gachon University, 21 Namdong-daero 774beon-gil, Namdong-gu, 21565, Incheon, Republic of Korea
    • Full Text Word Count:
      4921
    • ISSN:
      2234-0726
    • Accession Number:
      10.1186/s43019-019-0024-0
    • Accession Number:
      141752770
  • Citations
    • ABNT:
      KIM, K.-O. et al. The effect of interleukin-8 in the early stage after anterior cruciate ligament reconstruction with remnant preservation. Knee Surgery & Related Research, [s. l.], v. 32, n. 1, p. 1–9, 2020. DOI 10.1186/s43019-019-0024-0. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=141752770&custid=s8280428. Acesso em: 3 jul. 2020.
    • AMA:
      Kim K-O, Sim JA, Choi JU, Lee BK, Park HG. The effect of interleukin-8 in the early stage after anterior cruciate ligament reconstruction with remnant preservation. Knee Surgery & Related Research. 2020;32(1):1-9. doi:10.1186/s43019-019-0024-0.
    • AMA11:
      Kim K-O, Sim JA, Choi JU, Lee BK, Park HG. The effect of interleukin-8 in the early stage after anterior cruciate ligament reconstruction with remnant preservation. Knee Surgery & Related Research. 2020;32(1):1-9. doi:10.1186/s43019-019-0024-0
    • APA:
      Kim, K.-O., Sim, J. A., Choi, J. U., Lee, B. K., & Park, H. G. (2020). The effect of interleukin-8 in the early stage after anterior cruciate ligament reconstruction with remnant preservation. Knee Surgery & Related Research, 32(1), 1–9. https://doi.org/10.1186/s43019-019-0024-0
    • Chicago/Turabian: Author-Date:
      Kim, Kyung-Ok, Jae Ang Sim, Ji Uk Choi, Beom Koo Lee, and Hong Gi Park. 2020. “The Effect of Interleukin-8 in the Early Stage after Anterior Cruciate Ligament Reconstruction with Remnant Preservation.” Knee Surgery & Related Research 32 (1): 1–9. doi:10.1186/s43019-019-0024-0.
    • Harvard:
      Kim, K.-O. et al. (2020) ‘The effect of interleukin-8 in the early stage after anterior cruciate ligament reconstruction with remnant preservation’, Knee Surgery & Related Research, 32(1), pp. 1–9. doi: 10.1186/s43019-019-0024-0.
    • Harvard: Australian:
      Kim, K-O, Sim, JA, Choi, JU, Lee, BK & Park, HG 2020, ‘The effect of interleukin-8 in the early stage after anterior cruciate ligament reconstruction with remnant preservation’, Knee Surgery & Related Research, vol. 32, no. 1, pp. 1–9, viewed 3 July 2020, .
    • MLA:
      Kim, Kyung-Ok, et al. “The Effect of Interleukin-8 in the Early Stage after Anterior Cruciate Ligament Reconstruction with Remnant Preservation.” Knee Surgery & Related Research, vol. 32, no. 1, Mar. 2020, pp. 1–9. EBSCOhost, doi:10.1186/s43019-019-0024-0.
    • Chicago/Turabian: Humanities:
      Kim, Kyung-Ok, Jae Ang Sim, Ji Uk Choi, Beom Koo Lee, and Hong Gi Park. “The Effect of Interleukin-8 in the Early Stage after Anterior Cruciate Ligament Reconstruction with Remnant Preservation.” Knee Surgery & Related Research 32, no. 1 (March 2020): 1–9. doi:10.1186/s43019-019-0024-0.
    • Vancouver/ICMJE:
      Kim K-O, Sim JA, Choi JU, Lee BK, Park HG. The effect of interleukin-8 in the early stage after anterior cruciate ligament reconstruction with remnant preservation. Knee Surgery & Related Research [Internet]. 2020 Mar [cited 2020 Jul 3];32(1):1–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=141752770&custid=s8280428