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Imaging, biomarker and invasive assessment of diffuse left ventricular myocardial fibrosis in atrial fibrillation.

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  • معلومة اضافية
    • Author-Supplied Keywords:
      Atrial fibrillation
      Biomarkers
      Cardiovascular magnetic resonance imaging
      Fibrosis
      Voltage mapping
    • NAICS/Industry Codes:
      621512 Diagnostic Imaging Centers
    • Abstract:
      Background: Using cardiovascular magnetic resonance imaging (CMR), it is possible to detect diffuse fibrosis of the left ventricle (LV) in patients with atrial fibrillation (AF), which may be independently associated with recurrence of AF after ablation. By conducting CMR, clinical, electrophysiology and biomarker assessment we planned to investigate LV myocardial fibrosis in patients undergoing AF ablation. Methods: LV fibrosis was assessed by T1 mapping in 31 patients undergoing percutaneous ablation for AF. Galectin-3, coronary sinus type I collagen C terminal telopeptide (ICTP), and type III procollagen N terminal peptide were measured with ELISA. Comparison was made between groups above and below the median for LV extracellular volume fraction (ECV), followed by regression analysis. Results: On linear regression analysis LV ECV had significant associations with invasive left atrial pressure (Beta 0.49, P = 0.008) and coronary sinus ICTP (Beta 0.75, P < 0.001), which remained significant on multivariable regression. Conclusion: LV fibrosis in patients with AF is associated with left atrial pressure and invasively measured levels of ICTP turnover biomarker. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Author Affiliations:
      1Department of Cardiology, Leeds General Infirmary, X39 Cardiology Offices, Great George St, LS1 3EX, Leeds, UK
      2Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Clarendon Way, LS2 9JT, Leeds, UK
      3Department of Biomedical Engineering, King's College, London, UK
      4Institute of Biomedical Engineering, Karlsruhe Institute of Technology (KIT), 76131, Karlsruhe, Germany
      5MCRC and School of Biomedical Sciences, University of Leeds, LS2 9JT, Leeds, UK
      6University of Birmingham Institute of Cardiovascular Sciences, City Hospital, Birmingham, UK
      7University of Liverpool, Liverpool, UK
      8Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
    • Full Text Word Count:
      4635
    • ISSN:
      1532-429X
    • Accession Number:
      10.1186/s12968-020-0603-y
    • Accession Number:
      141625054
  • Citations
    • ABNT:
      BEGG, G. A. et al. Imaging, biomarker and invasive assessment of diffuse left ventricular myocardial fibrosis in atrial fibrillation. Journal of Cardiovascular Magnetic Resonance (BioMed Central), [s. l.], v. 22, n. 1, p. 1–7, 2020. DOI 10.1186/s12968-020-0603-y. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=141625054&custid=s8280428. Acesso em: 10 ago. 2020.
    • AMA:
      Begg GA, Swoboda PP, Karim R, et al. Imaging, biomarker and invasive assessment of diffuse left ventricular myocardial fibrosis in atrial fibrillation. Journal of Cardiovascular Magnetic Resonance (BioMed Central). 2020;22(1):1-7. doi:10.1186/s12968-020-0603-y
    • APA:
      Begg, G. A., Swoboda, P. P., Karim, R., Oesterlein, T., Rhode, K., Holden, A. V., Greenwood, J. P., Shantsila, E., Lip, G. Y. H., Plein, S., & Tayebjee, M. H. (2020). Imaging, biomarker and invasive assessment of diffuse left ventricular myocardial fibrosis in atrial fibrillation. Journal of Cardiovascular Magnetic Resonance (BioMed Central), 22(1), 1–7. https://doi.org/10.1186/s12968-020-0603-y
    • Chicago/Turabian: Author-Date:
      Begg, Gordon A., Peter P. Swoboda, Rashed Karim, Tobias Oesterlein, Kawal Rhode, Arun V. Holden, John P. Greenwood, et al. 2020. “Imaging, Biomarker and Invasive Assessment of Diffuse Left Ventricular Myocardial Fibrosis in Atrial Fibrillation.” Journal of Cardiovascular Magnetic Resonance (BioMed Central) 22 (1): 1–7. doi:10.1186/s12968-020-0603-y.
    • Harvard:
      Begg, G. A. et al. (2020) ‘Imaging, biomarker and invasive assessment of diffuse left ventricular myocardial fibrosis in atrial fibrillation’, Journal of Cardiovascular Magnetic Resonance (BioMed Central), 22(1), pp. 1–7. doi: 10.1186/s12968-020-0603-y.
    • Harvard: Australian:
      Begg, GA, Swoboda, PP, Karim, R, Oesterlein, T, Rhode, K, Holden, AV, Greenwood, JP, Shantsila, E, Lip, GYH, Plein, S & Tayebjee, MH 2020, ‘Imaging, biomarker and invasive assessment of diffuse left ventricular myocardial fibrosis in atrial fibrillation’, Journal of Cardiovascular Magnetic Resonance (BioMed Central), vol. 22, no. 1, pp. 1–7, viewed 10 August 2020, .
    • MLA:
      Begg, Gordon A., et al. “Imaging, Biomarker and Invasive Assessment of Diffuse Left Ventricular Myocardial Fibrosis in Atrial Fibrillation.” Journal of Cardiovascular Magnetic Resonance (BioMed Central), vol. 22, no. 1, Feb. 2020, pp. 1–7. EBSCOhost, doi:10.1186/s12968-020-0603-y.
    • Chicago/Turabian: Humanities:
      Begg, Gordon A., Peter P. Swoboda, Rashed Karim, Tobias Oesterlein, Kawal Rhode, Arun V. Holden, John P. Greenwood, et al. “Imaging, Biomarker and Invasive Assessment of Diffuse Left Ventricular Myocardial Fibrosis in Atrial Fibrillation.” Journal of Cardiovascular Magnetic Resonance (BioMed Central) 22, no. 1 (February 10, 2020): 1–7. doi:10.1186/s12968-020-0603-y.
    • Vancouver/ICMJE:
      Begg GA, Swoboda PP, Karim R, Oesterlein T, Rhode K, Holden AV, et al. Imaging, biomarker and invasive assessment of diffuse left ventricular myocardial fibrosis in atrial fibrillation. Journal of Cardiovascular Magnetic Resonance (BioMed Central) [Internet]. 2020 Feb 10 [cited 2020 Aug 10];22(1):1–7. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=141625054&custid=s8280428