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Sauchinone ameliorates intestinal inflammation and promotes Th17 cell production of IL-10 via Blimp-1.

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  • معلومة اضافية
    • Author-Supplied Keywords:
      Blimp-1
      Experimental colitis
      Inflammatory bowel disease
      Interleukin-10
      Sauchinone
      T helper 17 cell
    • NAICS/Industry Codes:
      111422 Floriculture Production
    • Abstract:
      Inflammatory bowel disease (IBD) is characterized by chronic, unpredictable relapsing and inflammatory disease of the gastrointestinal tract. Daily diet patterns have long been one of the most important hotspots for IBD therapeutic strategies. Sauchinone (SAU), a key bioactive lignin isolated from the roots of the herb Saururus chinensis , has been known to play an anti-inflammatory role in several diseases. However, its effect on IBD has not yet been investigated. In the current study, we established 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice and treated them with SAU. Flow cytometric analysis was performed to determine the phenotype of T cells in the lamina propria. qRT-PCR and ELISA were performed to measure cytokine transcript and protein levels, respectively. We found that SAU ameliorated TNBS-induced mouse colitis and inflammatory responses in mucosal tissues and peripheral blood CD4+ T cells from IBD patients. SAU significantly suppressed Th17 differentiation but facilitated IL-10 production, and SAU-treated Th17 cells exhibited inhibitory functions in vitro and in vivo. Mechanistically, we demonstrated that SAU induced Blimp-1 expression (encoded by Prdm1) in Th17 cells, and SAU failed to increase IL-10 production in Prdm1-knockout Th17 cells. Our data reveal an uncharacterized mechanism through which SAU regulates intestinal inflammation and Th17 differentiation. • Sauchinone ameliorates TNBS-induced colitis in mice. • Sauchinone inhibits Th17 differentiation but facilitates their production of IL-10. • Sauchinone enhances Th17 cell production of IL-10 via the Blimp-1 pathway. • Sauchinone suppresses inflammatory responses in human IBD. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Biochemical & Biophysical Research Communications is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China
      2Department of Gastroenterology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China
    • ISSN:
      0006-291X
    • Accession Number:
      10.1016/j.bbrc.2019.11.122
    • Accession Number:
      141135954
  • Citations
    • ABNT:
      XIAO, J. et al. Sauchinone ameliorates intestinal inflammation and promotes Th17 cell production of IL-10 via Blimp-1. Biochemical & Biophysical Research Communications, [s. l.], v. 522, n. 2, p. 435–441, 2020. DOI 10.1016/j.bbrc.2019.11.122. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=141135954&custid=s8280428. Acesso em: 9 ago. 2020.
    • AMA:
      Xiao J, Wang J, Chen Y, Zhou Z, Gao C, Guo Z. Sauchinone ameliorates intestinal inflammation and promotes Th17 cell production of IL-10 via Blimp-1. Biochemical & Biophysical Research Communications. 2020;522(2):435-441. doi:10.1016/j.bbrc.2019.11.122
    • APA:
      Xiao, J., Wang, J., Chen, Y., Zhou, Z., Gao, C., & Guo, Z. (2020). Sauchinone ameliorates intestinal inflammation and promotes Th17 cell production of IL-10 via Blimp-1. Biochemical & Biophysical Research Communications, 522(2), 435–441. https://doi.org/10.1016/j.bbrc.2019.11.122
    • Chicago/Turabian: Author-Date:
      Xiao, Jie, Jinxia Wang, Yanxi Chen, Zhou Zhou, Caiping Gao, and Zhenzhen Guo. 2020. “Sauchinone Ameliorates Intestinal Inflammation and Promotes Th17 Cell Production of IL-10 via Blimp-1.” Biochemical & Biophysical Research Communications 522 (2): 435–41. doi:10.1016/j.bbrc.2019.11.122.
    • Harvard:
      Xiao, J. et al. (2020) ‘Sauchinone ameliorates intestinal inflammation and promotes Th17 cell production of IL-10 via Blimp-1’, Biochemical & Biophysical Research Communications, 522(2), pp. 435–441. doi: 10.1016/j.bbrc.2019.11.122.
    • Harvard: Australian:
      Xiao, J, Wang, J, Chen, Y, Zhou, Z, Gao, C & Guo, Z 2020, ‘Sauchinone ameliorates intestinal inflammation and promotes Th17 cell production of IL-10 via Blimp-1’, Biochemical & Biophysical Research Communications, vol. 522, no. 2, pp. 435–441, viewed 9 August 2020, .
    • MLA:
      Xiao, Jie, et al. “Sauchinone Ameliorates Intestinal Inflammation and Promotes Th17 Cell Production of IL-10 via Blimp-1.” Biochemical & Biophysical Research Communications, vol. 522, no. 2, Feb. 2020, pp. 435–441. EBSCOhost, doi:10.1016/j.bbrc.2019.11.122.
    • Chicago/Turabian: Humanities:
      Xiao, Jie, Jinxia Wang, Yanxi Chen, Zhou Zhou, Caiping Gao, and Zhenzhen Guo. “Sauchinone Ameliorates Intestinal Inflammation and Promotes Th17 Cell Production of IL-10 via Blimp-1.” Biochemical & Biophysical Research Communications 522, no. 2 (February 5, 2020): 435–41. doi:10.1016/j.bbrc.2019.11.122.
    • Vancouver/ICMJE:
      Xiao J, Wang J, Chen Y, Zhou Z, Gao C, Guo Z. Sauchinone ameliorates intestinal inflammation and promotes Th17 cell production of IL-10 via Blimp-1. Biochemical & Biophysical Research Communications [Internet]. 2020 Feb 5 [cited 2020 Aug 9];522(2):435–41. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=141135954&custid=s8280428