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NOD1 and NOD2 in inflammation, immunity and disease.

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  • معلومة اضافية
    • Abstract:
      NOD1 and NOD2 are related intracellular sensors of bacterial peptidoglycan and belong to the Nod-like receptor (NLR) family of innate immune proteins that play fundamental and pleiotropic roles in host defense against infection and in the control of inflammation. The importance of these proteins is also highlighted by the genetic association between single nucleotide polymorphisms in NOD2 and susceptibility to Crohn's disease, an inflammatory bowel disease. At the cellular level, recent efforts have delineated the signaling pathways triggered following activation of NOD1 and NOD2, and the interplay with various cellular processes, such as autophagy. In vivo studies have revealed the importance of NOD-dependent host defense in models of infection, and a crucial area of investigation focuses on understanding the role of NOD1 and NOD2 at the intestinal mucosa, as this is of prime importance for understanding the etiology of Crohn's disease. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Archives of Biochemistry & Biophysics is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1Department of Immunology, University of Toronto, Toronto, Canada
      2Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
    • ISSN:
      0003-9861
    • Accession Number:
      10.1016/j.abb.2018.12.022
    • Accession Number:
      137851741
  • Citations
    • ABNT:
      MUKHERJEE, T. et al. NOD1 and NOD2 in inflammation, immunity and disease. Archives of Biochemistry & Biophysics, [s. l.], v. 670, p. 69–81, 2019. DOI 10.1016/j.abb.2018.12.022. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=137851741&custid=s8280428. Acesso em: 22 fev. 2020.
    • AMA:
      Mukherjee T, Hovingh ES, Foerster EG, Abdel-Nour M, Philpott DJ, Girardin SE. NOD1 and NOD2 in inflammation, immunity and disease. Archives of Biochemistry & Biophysics. 2019;670:69-81. doi:10.1016/j.abb.2018.12.022.
    • APA:
      Mukherjee, T., Hovingh, E. S., Foerster, E. G., Abdel-Nour, M., Philpott, D. J., & Girardin, S. E. (2019). NOD1 and NOD2 in inflammation, immunity and disease. Archives of Biochemistry & Biophysics, 670, 69–81. https://doi.org/10.1016/j.abb.2018.12.022
    • Chicago/Turabian: Author-Date:
      Mukherjee, Tapas, Elise Sofie Hovingh, Elisabeth G. Foerster, Mena Abdel-Nour, Dana J. Philpott, and Stephen E. Girardin. 2019. “NOD1 and NOD2 in Inflammation, Immunity and Disease.” Archives of Biochemistry & Biophysics 670 (July): 69–81. doi:10.1016/j.abb.2018.12.022.
    • Harvard:
      Mukherjee, T. et al. (2019) ‘NOD1 and NOD2 in inflammation, immunity and disease’, Archives of Biochemistry & Biophysics, 670, pp. 69–81. doi: 10.1016/j.abb.2018.12.022.
    • Harvard: Australian:
      Mukherjee, T, Hovingh, ES, Foerster, EG, Abdel-Nour, M, Philpott, DJ & Girardin, SE 2019, ‘NOD1 and NOD2 in inflammation, immunity and disease’, Archives of Biochemistry & Biophysics, vol. 670, pp. 69–81, viewed 22 February 2020, .
    • MLA:
      Mukherjee, Tapas, et al. “NOD1 and NOD2 in Inflammation, Immunity and Disease.” Archives of Biochemistry & Biophysics, vol. 670, July 2019, pp. 69–81. EBSCOhost, doi:10.1016/j.abb.2018.12.022.
    • Chicago/Turabian: Humanities:
      Mukherjee, Tapas, Elise Sofie Hovingh, Elisabeth G. Foerster, Mena Abdel-Nour, Dana J. Philpott, and Stephen E. Girardin. “NOD1 and NOD2 in Inflammation, Immunity and Disease.” Archives of Biochemistry & Biophysics 670 (July 30, 2019): 69–81. doi:10.1016/j.abb.2018.12.022.
    • Vancouver/ICMJE:
      Mukherjee T, Hovingh ES, Foerster EG, Abdel-Nour M, Philpott DJ, Girardin SE. NOD1 and NOD2 in inflammation, immunity and disease. Archives of Biochemistry & Biophysics [Internet]. 2019 Jul 30 [cited 2020 Feb 22];670:69–81. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=137851741&custid=s8280428