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A20 in dendritic cells restrains intestinal anti-bacterial peptide expression and preserves commensal homeostasis.

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  • معلومة اضافية
    • Author-Supplied Keywords:
      Amniotes
      Anatomy
      Animal cells
      Animals
      Antibacterials
      Antimicrobials
      Biochemistry
      Biology and life sciences
      Blood cells
      Cell biology
      Cellular types
      Defensins
      Digestive system
      Drugs
      Eukaryota
      Gastroenterology and hepatology
      Gastrointestinal tract
      Genetics
      Genomics
      Homeostasis
      Immune cells
      Immune system proteins
      Immunology
      Inflammatory bowel disease
      Lymphocytes
      Mammals
      Medical microbiology
      Medicine and health sciences
      Mice
      Microbial control
      Microbial genomics
      Microbiology
      Microbiome
      Organisms
      Pharmacology
      Physiological processes
      Physiology
      Proteins
      Research Article
      Rodents
      Vertebrates
      White blood cells
    • Abstract:
      Microbial dysbiosis commonly occurs in patients with inflammatory bowel diseases (IBD). Exogenous causes of dysbiosis such as antibiotics and diet are well described, but host derived causes are understudied. A20 is a potent regulator of signals triggered by microbial pattern molecules, and A20 regulates susceptibility to intestinal inflammation in mice and in humans. We now report that mice lacking A20 expression in dendritic cells, A20FL/FL CD11c-Cre mice (or A20dDC mice), spontaneously develop colitogenic intestinal dysbiosis that is evident upon weaning and precedes the onset of colitis. Intestines from A20dDC mice express increased amounts of Reg3β and Reg3γ, but not Ang4. A20 deficient DCs promote gut microbiota perturbation in the absence of adaptive lymphocytes. Moreover, A20 deficient DCs directly induce expression of Reg3β and Reg3γ but not Ang 4 in normal intestinal epithelial cell enteroid cultures in the absence of other cell types. These findings reveal a pathophysiological pathway in which defective expression of an IBD susceptibility gene in DCs drives aberrant expression of anti-bacterial peptides and luminal dysbiosis that in turn confers host susceptibility to intestinal inflammation. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1Department of Medicine, University of California, San Francisco, San Francisco, CA, United States of America
    • Full Text Word Count:
      4833
    • ISSN:
      1932-6203
    • Accession Number:
      10.1371/journal.pone.0218999
    • Accession Number:
      137426707
  • Citations
    • ABNT:
      TALPIN, A. et al. A20 in dendritic cells restrains intestinal anti-bacterial peptide expression and preserves commensal homeostasis. PLoS ONE, [s. l.], v. 14, n. 7, p. 1–12, 2019. DOI 10.1371/journal.pone.0218999. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=137426707&custid=s8280428. Acesso em: 26 fev. 2020.
    • AMA:
      Talpin A, Kattah MG, Advincula R, et al. A20 in dendritic cells restrains intestinal anti-bacterial peptide expression and preserves commensal homeostasis. PLoS ONE. 2019;14(7):1-12. doi:10.1371/journal.pone.0218999.
    • APA:
      Talpin, A., Kattah, M. G., Advincula, R., Fadrosh, D., Lynch, K., LaMere, B., Fujimura, K. E., Nagalingam, N. A., Malynn, B. A., Lynch, S. V., & Ma, A. (2019). A20 in dendritic cells restrains intestinal anti-bacterial peptide expression and preserves commensal homeostasis. PLoS ONE, 14(7), 1–12. https://doi.org/10.1371/journal.pone.0218999
    • Chicago/Turabian: Author-Date:
      Talpin, Alice, Michael G. Kattah, Rommel Advincula, Douglas Fadrosh, Kole Lynch, Brandon LaMere, Kei E. Fujimura, et al. 2019. “A20 in Dendritic Cells Restrains Intestinal Anti-Bacterial Peptide Expression and Preserves Commensal Homeostasis.” PLoS ONE 14 (7): 1–12. doi:10.1371/journal.pone.0218999.
    • Harvard:
      Talpin, A. et al. (2019) ‘A20 in dendritic cells restrains intestinal anti-bacterial peptide expression and preserves commensal homeostasis’, PLoS ONE, 14(7), pp. 1–12. doi: 10.1371/journal.pone.0218999.
    • Harvard: Australian:
      Talpin, A, Kattah, MG, Advincula, R, Fadrosh, D, Lynch, K, LaMere, B, Fujimura, KE, Nagalingam, NA, Malynn, BA, Lynch, SV & Ma, A 2019, ‘A20 in dendritic cells restrains intestinal anti-bacterial peptide expression and preserves commensal homeostasis’, PLoS ONE, vol. 14, no. 7, pp. 1–12, viewed 26 February 2020, .
    • MLA:
      Talpin, Alice, et al. “A20 in Dendritic Cells Restrains Intestinal Anti-Bacterial Peptide Expression and Preserves Commensal Homeostasis.” PLoS ONE, vol. 14, no. 7, July 2019, pp. 1–12. EBSCOhost, doi:10.1371/journal.pone.0218999.
    • Chicago/Turabian: Humanities:
      Talpin, Alice, Michael G. Kattah, Rommel Advincula, Douglas Fadrosh, Kole Lynch, Brandon LaMere, Kei E. Fujimura, et al. “A20 in Dendritic Cells Restrains Intestinal Anti-Bacterial Peptide Expression and Preserves Commensal Homeostasis.” PLoS ONE 14, no. 7 (July 11, 2019): 1–12. doi:10.1371/journal.pone.0218999.
    • Vancouver/ICMJE:
      Talpin A, Kattah MG, Advincula R, Fadrosh D, Lynch K, LaMere B, et al. A20 in dendritic cells restrains intestinal anti-bacterial peptide expression and preserves commensal homeostasis. PLoS ONE [Internet]. 2019 Jul 11 [cited 2020 Feb 26];14(7):1–12. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=137426707&custid=s8280428