Multicentre randomised trial comparing contact force with electrical coupling index in atrial flutter ablation (VERISMART trial).

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  • معلومة اضافية
    • Author-Supplied Keywords:
      Analysis of variance
      Anatomy
      Arrhythmia
      Atrial fibrillation
      Bioassays and physiological analysis
      Bioengineering
      Biology and life sciences
      Biotechnology
      Capacitance
      Cardiac electrophysiology
      Cardiology
      Cardiovascular anatomy
      Catheters
      Diagnostic medicine
      Earth sciences
      Electrocardiography
      Electrophysiological techniques
      Engineering and technology
      Heart
      Lesions
      Material properties
      Materials science
      Mathematical and statistical techniques
      Mathematics
      Medical devices and equipment
      Medicine and health sciences
      Myocardium
      Pathology and laboratory medicine
      Physical sciences
      Research and analysis methods
      Research Article
      Seasons
      Signs and symptoms
      Spring
      Statistical methods
      Statistics
    • NAICS/Industry Codes:
      541712 Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology)
    • Abstract:
      Introduction: Electrical coupling index (ECI) and contact force (CF) have been developed to aid lesion formation during catheter ablation. ECI measures tissue impedance and capacitance whilst CF measures direct contact. The aim was to determine whether the presence of catheter / tissue interaction information, such as ECI and CF, reduce time to achieve bidirectional cavotricuspid isthmus block during atrial flutter (AFL) ablation. Methods: Patients with paroxysmal or persistent AFL were randomised to CF visible (range 5-40g), CF not visible, ECI visible (change of 12%) or ECI not visible. Follow-up occurred at 3 and 6 months and included a 7 day ECG recording. The primary endpoint was time to bidirectional cavotricuspid isthmus block. Results: 114 patients were randomised, 16 were excluded. Time to bidirectional block was significantly shorter when ECI was visible (median 30.0 mins (IQR 31) to median 10.5mins (IQR 12) p 0.023) versus ECI not visible. There was a trend towards a shorter time to bidirectional block when CF was visible. Higher force was applied when CF was visible (median 9.03g (IQR 7.4) vs. 11.3g (5.5) p 0.017). There was no difference in the acute recurrence of conduction between groups. The complication rate was 2%, AFL recurrence was 1.1% and at 6 month follow-up, 12% had atrial fibrillation. Conclusion: The use of tissue contact information during AFL ablation was associated with reduced time taken to achieve bidirectional block when ECI was visible. Contact force data improved contact when visible with a trend towards a reduction in the procedural endpoint. ClinicalTrials.gov trial identifier: . [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Author Affiliations:
      1Department of Cardiology, Leeds Teaching Hospitals NHS Trust, Leeds General Infirmary, Leeds, United Kingdom
      2Department of Cardiology, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, United Kingdom
      3Department of Cardiology, Barts Health NHS Trust, St Bartholomew’s Hospital, London, United Kingdom
    • Full Text Word Count:
      5617
    • ISSN:
      1932-6203
    • Accession Number:
      10.1371/journal.pone.0212903
    • Accession Number:
      135705085
  • Citations
    • ABNT:
      BEGG, G. A. et al. Multicentre randomised trial comparing contact force with electrical coupling index in atrial flutter ablation (VERISMART trial). PLoS ONE, [s. l.], v. 14, n. 4, p. 1–13, 2019. Disponível em: . Acesso em: 11 nov. 2019.
    • AMA:
      Begg GA, O NJ, Sohaib A, et al. Multicentre randomised trial comparing contact force with electrical coupling index in atrial flutter ablation (VERISMART trial). PLoS ONE. 2019;14(4):1-13. doi:10.1371/journal.pone.0212903.
    • APA:
      Begg, G. A., O, N. J., Sohaib, A., McLean, A., Pepper, C. B., Graham, L. N., … Tayebjee, M. H. (2019). Multicentre randomised trial comparing contact force with electrical coupling index in atrial flutter ablation (VERISMART trial). PLoS ONE, 14(4), 1–13. https://doi.org/10.1371/journal.pone.0212903
    • Chicago/Turabian: Author-Date:
      Begg, Gordon A., Neill, James O, Afzal Sohaib, Ailsa McLean, Chris B. Pepper, Lee N. Graham, Andrew J. Hogarth, et al. 2019. “Multicentre Randomised Trial Comparing Contact Force with Electrical Coupling Index in Atrial Flutter Ablation (VERISMART Trial).” PLoS ONE 14 (4): 1–13. doi:10.1371/journal.pone.0212903.
    • Harvard:
      Begg, G. A. et al. (2019) ‘Multicentre randomised trial comparing contact force with electrical coupling index in atrial flutter ablation (VERISMART trial)’, PLoS ONE, 14(4), pp. 1–13. doi: 10.1371/journal.pone.0212903.
    • Harvard: Australian:
      Begg, GA, O, NJ, Sohaib, A, McLean, A, Pepper, CB, Graham, LN, Hogarth, AJ, Page, SP, Gillott, RG, Hill, N, Walshaw, J, Schilling, RJ, Kanagaratnam, P & Tayebjee, MH 2019, ‘Multicentre randomised trial comparing contact force with electrical coupling index in atrial flutter ablation (VERISMART trial)’, PLoS ONE, vol. 14, no. 4, pp. 1–13, viewed 11 November 2019, .
    • MLA:
      Begg, Gordon A., et al. “Multicentre Randomised Trial Comparing Contact Force with Electrical Coupling Index in Atrial Flutter Ablation (VERISMART Trial).” PLoS ONE, vol. 14, no. 4, Apr. 2019, pp. 1–13. EBSCOhost, doi:10.1371/journal.pone.0212903.
    • Chicago/Turabian: Humanities:
      Begg, Gordon A., Neill, James O, Afzal Sohaib, Ailsa McLean, Chris B. Pepper, Lee N. Graham, Andrew J. Hogarth, et al. “Multicentre Randomised Trial Comparing Contact Force with Electrical Coupling Index in Atrial Flutter Ablation (VERISMART Trial).” PLoS ONE 14, no. 4 (April 3, 2019): 1–13. doi:10.1371/journal.pone.0212903.
    • Vancouver/ICMJE:
      Begg GA, O NJ, Sohaib A, McLean A, Pepper CB, Graham LN, et al. Multicentre randomised trial comparing contact force with electrical coupling index in atrial flutter ablation (VERISMART trial). PLoS ONE [Internet]. 2019 Apr 3 [cited 2019 Nov 11];14(4):1–13. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=135705085&custid=s8280428