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Induction of circulating T follicular helper cells and regulatory T cells correlating with HIV-1 gp120 variable loop antibodies by a subtype C prophylactic vaccine tested in a Phase I trial in India.

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  • معلومة اضافية
    • Author-Supplied Keywords:
      Animal cells
      Antibodies
      Antibody response
      Antibody-producing cells
      B cells
      Biochemistry
      Biology and life sciences
      Blood cells
      Cell biology
      Cellular types
      HIV
      HIV vaccines
      HIV-1
      Immune cells
      Immune physiology
      Immune response
      Immune system proteins
      Immunodeficiency viruses
      Immunology
      Infectious disease control
      Infectious diseases
      Lentivirus
      Medical microbiology
      Medicine and health sciences
      Microbial pathogens
      Microbiology
      Organisms
      Pathogens
      Pathology and laboratory medicine
      Physiology
      Preventive medicine
      Proteins
      Public and occupational health
      Regulatory T cells
      Research Article
      Retroviruses
      RNA viruses
      T cells
      Vaccination and immunization
      Vaccines
      Viral pathogens
      Viral vaccines
      Virology
      Viruses
      White blood cells
    • Abstract:
      A Phase I HIV-1 vaccine trial sponsored by the International AIDS Vaccine Initiative (IAVI) was conducted in India in 2009 to test a subtype C prophylactic vaccine in a prime-boost regimen comprising of a DNA prime (ADVAX) and MVA (TBC-M4) boost. The trial demonstrated that the regimen was safe and well tolerated and resulted in enhancement of HIV-specific immune responses. Preliminary observations on vaccine-induced immune responses were limited to analysis of neutralizing antibodies and IFN-γ ELISPOT response. The present study involves a more detailed analysis of the nature of the vaccine-induced humoral immune response using specimens that were archived from the volunteers at the time of the trial. Interestingly, we found vaccine induced production of V1/V2 and V3 region-specific antibodies in a significant proportion of vaccinees. Variable region antibody levels correlated directly with the frequency of circulating T follicular helper cells (Tfh) and regulatory T cells (Treg). Our findings provide encouraging evidence to demonstrate the immunogenicity of the tested vaccine. Better insights into vaccine-induced immune responses can aid in informing future design of a successfulHIV-1 vaccine. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1National Institute for Research in Tuberculosis (Indian Council of Medical Research), Chennai, India
      2International AIDS Vaccine Initiative, New Delhi, India
      3IAVI Human Immunology Laboratory, Imperial College, London, United Kingdom
    • Full Text Word Count:
      8596
    • ISSN:
      1932-6203
    • Accession Number:
      10.1371/journal.pone.0203037
    • Accession Number:
      131482295
  • Citations
    • ABNT:
      MUNUSAMY PONNAN, S. et al. Induction of circulating T follicular helper cells and regulatory T cells correlating with HIV-1 gp120 variable loop antibodies by a subtype C prophylactic vaccine tested in a Phase I trial in India. PLoS ONE, [s. l.], v. 13, n. 8, p. 1–16, 2018. DOI 10.1371/journal.pone.0203037. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=131482295&custid=s8280428. Acesso em: 15 ago. 2020.
    • AMA:
      Munusamy Ponnan S, Swaminathan S, Tiruvengadam K, et al. Induction of circulating T follicular helper cells and regulatory T cells correlating with HIV-1 gp120 variable loop antibodies by a subtype C prophylactic vaccine tested in a Phase I trial in India. PLoS ONE. 2018;13(8):1-16. doi:10.1371/journal.pone.0203037
    • APA:
      Munusamy Ponnan, S., Swaminathan, S., Tiruvengadam, K., K. K., V., Cheedarla, N., Nesakumar, M., Kathirvel, S., Goyal, R., Singla, N., Mukherjee, J., Bergin, P., T. Kopycinski, J., Gilmour, J., Prasad Tripathy, S., & Elizabeth, L. H. (2018). Induction of circulating T follicular helper cells and regulatory T cells correlating with HIV-1 gp120 variable loop antibodies by a subtype C prophylactic vaccine tested in a Phase I trial in India. PLoS ONE, 13(8), 1–16. https://doi.org/10.1371/journal.pone.0203037
    • Chicago/Turabian: Author-Date:
      Munusamy Ponnan, Sivasankaran, Soumya Swaminathan, Kannan Tiruvengadam, Vidyavijayan K. K., Narayana Cheedarla, Manohar Nesakumar, Sujitha Kathirvel, et al. 2018. “Induction of Circulating T Follicular Helper Cells and Regulatory T Cells Correlating with HIV-1 Gp120 Variable Loop Antibodies by a Subtype C Prophylactic Vaccine Tested in a Phase I Trial in India.” PLoS ONE 13 (8): 1–16. doi:10.1371/journal.pone.0203037.
    • Harvard:
      Munusamy Ponnan, S. et al. (2018) ‘Induction of circulating T follicular helper cells and regulatory T cells correlating with HIV-1 gp120 variable loop antibodies by a subtype C prophylactic vaccine tested in a Phase I trial in India’, PLoS ONE, 13(8), pp. 1–16. doi: 10.1371/journal.pone.0203037.
    • Harvard: Australian:
      Munusamy Ponnan, S, Swaminathan, S, Tiruvengadam, K, K. K., V, Cheedarla, N, Nesakumar, M, Kathirvel, S, Goyal, R, Singla, N, Mukherjee, J, Bergin, P, T. Kopycinski, J, Gilmour, J, Prasad Tripathy, S & Elizabeth, LH 2018, ‘Induction of circulating T follicular helper cells and regulatory T cells correlating with HIV-1 gp120 variable loop antibodies by a subtype C prophylactic vaccine tested in a Phase I trial in India’, PLoS ONE, vol. 13, no. 8, pp. 1–16, viewed 15 August 2020, .
    • MLA:
      Munusamy Ponnan, Sivasankaran, et al. “Induction of Circulating T Follicular Helper Cells and Regulatory T Cells Correlating with HIV-1 Gp120 Variable Loop Antibodies by a Subtype C Prophylactic Vaccine Tested in a Phase I Trial in India.” PLoS ONE, vol. 13, no. 8, Aug. 2018, pp. 1–16. EBSCOhost, doi:10.1371/journal.pone.0203037.
    • Chicago/Turabian: Humanities:
      Munusamy Ponnan, Sivasankaran, Soumya Swaminathan, Kannan Tiruvengadam, Vidyavijayan K. K., Narayana Cheedarla, Manohar Nesakumar, Sujitha Kathirvel, et al. “Induction of Circulating T Follicular Helper Cells and Regulatory T Cells Correlating with HIV-1 Gp120 Variable Loop Antibodies by a Subtype C Prophylactic Vaccine Tested in a Phase I Trial in India.” PLoS ONE 13, no. 8 (August 29, 2018): 1–16. doi:10.1371/journal.pone.0203037.
    • Vancouver/ICMJE:
      Munusamy Ponnan S, Swaminathan S, Tiruvengadam K, K. K. V, Cheedarla N, Nesakumar M, et al. Induction of circulating T follicular helper cells and regulatory T cells correlating with HIV-1 gp120 variable loop antibodies by a subtype C prophylactic vaccine tested in a Phase I trial in India. PLoS ONE [Internet]. 2018 Aug 29 [cited 2020 Aug 15];13(8):1–16. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=131482295&custid=s8280428