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Calculate of withdrawal times of clenbuterol in goats to obtain safe times of slaughter.

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  • معلومة اضافية
    • Author-Supplied Keywords:
      elimination half-life
      new method for calculating withdrawal time
      prescriptions for obtained β2-agonist
      prescriptions for obtained β2-agonist
      residues in liver
    • NAICS/Industry Codes:
      411110 Live animal merchant wholesalers
      112420 Goat Farming
      424520 Livestock Merchant Wholesalers
      311611 Animal (except Poultry) Slaughtering
    • Abstract:
      Background and Aim: Clenbuterol as a β2-agonist drug was investigated according to the concentration of the drug available in the bodies of goats and according to the level of sensitivity of the instruments used for detection. The objective of the current study was to determine withdrawal times after giving a therapeutic dose that resulted in safe slaughters. Materials and Methods: Five healthy male goats with a mean body weight of 20.64 kg were treated with a single dose of 5.10-3 mg/kg in the BW onto jugular vein. Whole blood samples of approximately 5 mL were taken in a time series at 5, 30, 60, 90, 150, 210, 270, 390, 510, 630, and 750 min. At 24 h posttreatment, all subjects were sacrificed, and 300 g samples of the liver were obtained. The plasma concentration and liver residue of the drug were observed by reverse-phase high- performance liquid chromatography. Results: The drug reached a maximum concentration of 19.233±0.331 µg/mL at 5 min, and the elimination half-life was at 173.25 min. The limit detection was obtained at 0.053 µg/mL. A one-way analysis of variance between all goats showed that elimination of the clenbuterol in their bodies was similar (p=1.00), with a withdrawal time of 1,479.326 min and no residues in the liver (p<0.05). Conclusion: Safe times for slaughter were determined to be at 2 days, 13 h, and 12 min as the 2nd safety factor (SF) time and 3 days, 1 h, and 58 min as the 3rd SF time with the liver organ free from residue. [ABSTRACT FROM AUTHOR]
    • Abstract:
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    • Author Affiliations:
      1Department of Basic Science, Veterinary Pharmacy Subdivision, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia
      2Department of Pharmacology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
      3Department of Reproduction, Faculty of Veterinary Medicine, Airlangga University, Surabaya, Indonesia
    • ISSN:
      0972-8988
    • Accession Number:
      10.14202/vetworld.2018.731-738
    • Accession Number:
      130667575
  • Citations
    • ABNT:
      MOCHAMAD, L.; HERMANTO, B.; RESTIADI, T. I. Calculate of withdrawal times of clenbuterol in goats to obtain safe times of slaughter. Veterinary World, [s. l.], v. 11, n. 6, p. 731–738, 2018. DOI 10.14202/vetworld.2018.731-738. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=130667575&custid=s8280428. Acesso em: 10 jul. 2020.
    • AMA:
      Mochamad L, Hermanto B, Restiadi TI. Calculate of withdrawal times of clenbuterol in goats to obtain safe times of slaughter. Veterinary World. 2018;11(6):731-738. doi:10.14202/vetworld.2018.731-738.
    • AMA11:
      Mochamad L, Hermanto B, Restiadi TI. Calculate of withdrawal times of clenbuterol in goats to obtain safe times of slaughter. Veterinary World. 2018;11(6):731-738. doi:10.14202/vetworld.2018.731-738
    • APA:
      Mochamad, L., Hermanto, B., & Restiadi, T. I. (2018). Calculate of withdrawal times of clenbuterol in goats to obtain safe times of slaughter. Veterinary World, 11(6), 731–738. https://doi.org/10.14202/vetworld.2018.731-738
    • Chicago/Turabian: Author-Date:
      Mochamad, Lazuardi, Bambang Hermanto, and T. I. Restiadi. 2018. “Calculate of Withdrawal Times of Clenbuterol in Goats to Obtain Safe Times of Slaughter.” Veterinary World 11 (6): 731–38. doi:10.14202/vetworld.2018.731-738.
    • Harvard:
      Mochamad, L., Hermanto, B. and Restiadi, T. I. (2018) ‘Calculate of withdrawal times of clenbuterol in goats to obtain safe times of slaughter’, Veterinary World, 11(6), pp. 731–738. doi: 10.14202/vetworld.2018.731-738.
    • Harvard: Australian:
      Mochamad, L, Hermanto, B & Restiadi, TI 2018, ‘Calculate of withdrawal times of clenbuterol in goats to obtain safe times of slaughter’, Veterinary World, vol. 11, no. 6, pp. 731–738, viewed 10 July 2020, .
    • MLA:
      Mochamad, Lazuardi, et al. “Calculate of Withdrawal Times of Clenbuterol in Goats to Obtain Safe Times of Slaughter.” Veterinary World, vol. 11, no. 6, June 2018, pp. 731–738. EBSCOhost, doi:10.14202/vetworld.2018.731-738.
    • Chicago/Turabian: Humanities:
      Mochamad, Lazuardi, Bambang Hermanto, and T. I. Restiadi. “Calculate of Withdrawal Times of Clenbuterol in Goats to Obtain Safe Times of Slaughter.” Veterinary World 11, no. 6 (June 2018): 731–38. doi:10.14202/vetworld.2018.731-738.
    • Vancouver/ICMJE:
      Mochamad L, Hermanto B, Restiadi TI. Calculate of withdrawal times of clenbuterol in goats to obtain safe times of slaughter. Veterinary World [Internet]. 2018 Jun [cited 2020 Jul 10];11(6):731–8. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=130667575&custid=s8280428