Distinct Effects of Type I and III Interferons on Enteric Viruses.

Item request has been placed! ×
Item request cannot be made. ×
  Processing Request
  • معلومة اضافية
    • Author-Supplied Keywords:
      immunity
      interferon
      microbiota
      norovirus
      reovirus
      rotavirus
    • NAICS/Industry Codes:
      325410 Pharmaceutical and medicine manufacturing
    • Abstract:
      Interferons (IFNs) are key host cytokines in the innate immune response to viral infection, and recent work has identified unique roles for IFN subtypes in regulating different aspects of infection. Currently emerging is a common theme that type III IFNs are critical in localized control of infection at mucosal barrier sites, while type I IFNs are important for broad systemic control of infections. The intestine is a particular site of interest for exploring these effects, as in addition to being the port of entry for a multitude of pathogens, it is a complex tissue with a variety of cell types as well as the presence of the intestinal microbiota. Here we focus on the roles of type I and III IFNs in control of enteric viruses, discussing what is known about signaling downstream from these cytokines, including induction of specific IFN-stimulated genes. We review viral strategies to evade IFN responses, effects of IFNs on the intestine, interactions between IFNs and the microbiota, and briefly discuss the role of IFNs in controlling viral infections at other barrier sites. Enhanced understanding of the coordinate roles of IFNs in control of viral infections may facilitate development of antiviral therapeutic strategies; here we highlight potential avenues for future exploration. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Viruses (1999-4915) is the property of MDPI Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
    • Full Text Word Count:
      14598
    • ISSN:
      1999-4915
    • Accession Number:
      10.3390/v10010046
    • Accession Number:
      127638903
  • Citations
    • ABNT:
      INGLE, H.; PETERSON, S. T.; BALDRIDGE, M. T. Distinct Effects of Type I and III Interferons on Enteric Viruses. Viruses (1999-4915), [s. l.], v. 10, n. 1, p. 46, 2018. Disponível em: . Acesso em: 18 nov. 2019.
    • AMA:
      Ingle H, Peterson ST, Baldridge MT. Distinct Effects of Type I and III Interferons on Enteric Viruses. Viruses (1999-4915). 2018;10(1):46. doi:10.3390/v10010046.
    • APA:
      Ingle, H., Peterson, S. T., & Baldridge, M. T. (2018). Distinct Effects of Type I and III Interferons on Enteric Viruses. Viruses (1999-4915), 10(1), 46. https://doi.org/10.3390/v10010046
    • Chicago/Turabian: Author-Date:
      Ingle, Harshad, Stefan T. Peterson, and Megan T. Baldridge. 2018. “Distinct Effects of Type I and III Interferons on Enteric Viruses.” Viruses (1999-4915) 10 (1): 46. doi:10.3390/v10010046.
    • Harvard:
      Ingle, H., Peterson, S. T. and Baldridge, M. T. (2018) ‘Distinct Effects of Type I and III Interferons on Enteric Viruses’, Viruses (1999-4915), 10(1), p. 46. doi: 10.3390/v10010046.
    • Harvard: Australian:
      Ingle, H, Peterson, ST & Baldridge, MT 2018, ‘Distinct Effects of Type I and III Interferons on Enteric Viruses’, Viruses (1999-4915), vol. 10, no. 1, p. 46, viewed 18 November 2019, .
    • MLA:
      Ingle, Harshad, et al. “Distinct Effects of Type I and III Interferons on Enteric Viruses.” Viruses (1999-4915), vol. 10, no. 1, Jan. 2018, p. 46. EBSCOhost, doi:10.3390/v10010046.
    • Chicago/Turabian: Humanities:
      Ingle, Harshad, Stefan T. Peterson, and Megan T. Baldridge. “Distinct Effects of Type I and III Interferons on Enteric Viruses.” Viruses (1999-4915) 10, no. 1 (January 2018): 46. doi:10.3390/v10010046.
    • Vancouver/ICMJE:
      Ingle H, Peterson ST, Baldridge MT. Distinct Effects of Type I and III Interferons on Enteric Viruses. Viruses (1999-4915) [Internet]. 2018 Jan [cited 2019 Nov 18];10(1):46. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=127638903&custid=s8280428