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Effects of Angelicae Pubescentis and Loranthi Decotion on repairing knee joint cartilages in rats.

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  • معلومة اضافية
    • Author-Supplied Keywords:
      Angelicae Pubescentis and Loranthi decotion
      Chondrocyte
      Duhuo
      Knee osteoarthritis
      Serum
    • NAICS/Industry Codes:
      112990 All Other Animal Production
    • Abstract:
      Background: Knee osteoarthritis (KOA) is a common orthopedics disease and its pathological changes at early stage are the damage and loss of articular cartilage. Traditional Chinese medicine (TCM) prescription contains multiple components and has the unique advantages of the diversity of targets.We compared the traditional Chinese medical formulae (Angelicae Pubescentis and Loranthi decotion, APLD, or Duhuo Jisheng) with a western medicine (glucosamine sulfate, GS) to treat the rat arthritis models, and tracked the outcomes. Methods: Thirty-two Wistar rats (weight 180 ± 10 g, 6-week-old) were randomly divided into four groups (eight for each): group A as normal control group (no surgery and no drug treatment), group B as SIA (surgery-induced arthritis) model control without drug treatment, group C as SIA model + APLD, and group D as SIA model + GS. Anterior cruciate ligament in the knee joint of both hind legs from each rat in groups B, C, and D was shown and cut off to establish the SIA model. After 6 weeks of the surgery, rats in group C or D were treated with APLD or GS, respectively, for 8 weeks. Bone X-ray examination, histological images, and determination of genes of collagen II and aggrecan were performed. At week 14, both knee joint gap and bone structure disappeared in rats of group B, but they were visible in rats of groups A, C, and D. Results: Histological images revealed that the structure and composition of the knee joint cartilage were significantly degenerated in group B and improved in group C. Genes of collagen II and aggrecan were significantly increased in both group C and D. Conclusion: APLD or GS gavage treatment for knee osteoarthritis (KOA) rat models was effective on the proliferation of cartilage chondrocytes and the damaged knee joint tissue repairing, and the APLD showed slightly superior in general. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Journal of Orthopaedic Surgery & Research is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1Department of orthopedics, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, No. 164 Lanxi Rd, Shanghai 200062, China
    • ISSN:
      1749-799X
    • Accession Number:
      10.1186/s13018-017-0679-8
    • Accession Number:
      126824931
  • Citations
    • ABNT:
      SHUN LYU et al. Effects of Angelicae Pubescentis and Loranthi Decotion on repairing knee joint cartilages in rats. Journal of Orthopaedic Surgery & Research, [s. l.], v. 12, p. 1–7, 2017. DOI 10.1186/s13018-017-0679-8. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=126824931&custid=s8280428. Acesso em: 30 mar. 2020.
    • AMA:
      Shun Lyu, Bin Ji, Wenwu Gao, Xianqi Chen, Xiaotao Xie, Junjie Zhou. Effects of Angelicae Pubescentis and Loranthi Decotion on repairing knee joint cartilages in rats. Journal of Orthopaedic Surgery & Research. 2017;12:1-7. doi:10.1186/s13018-017-0679-8.
    • APA:
      Shun Lyu, Bin Ji, Wenwu Gao, Xianqi Chen, Xiaotao Xie, & Junjie Zhou. (2017). Effects of Angelicae Pubescentis and Loranthi Decotion on repairing knee joint cartilages in rats. Journal of Orthopaedic Surgery & Research, 12, 1–7. https://doi.org/10.1186/s13018-017-0679-8
    • Chicago/Turabian: Author-Date:
      Shun Lyu, Bin Ji, Wenwu Gao, Xianqi Chen, Xiaotao Xie, and Junjie Zhou. 2017. “Effects of Angelicae Pubescentis and Loranthi Decotion on Repairing Knee Joint Cartilages in Rats.” Journal of Orthopaedic Surgery & Research 12 (December): 1–7. doi:10.1186/s13018-017-0679-8.
    • Harvard:
      Shun Lyu et al. (2017) ‘Effects of Angelicae Pubescentis and Loranthi Decotion on repairing knee joint cartilages in rats’, Journal of Orthopaedic Surgery & Research, 12, pp. 1–7. doi: 10.1186/s13018-017-0679-8.
    • Harvard: Australian:
      Shun Lyu, Bin Ji, Wenwu Gao, Xianqi Chen, Xiaotao Xie & Junjie Zhou 2017, ‘Effects of Angelicae Pubescentis and Loranthi Decotion on repairing knee joint cartilages in rats’, Journal of Orthopaedic Surgery & Research, vol. 12, pp. 1–7, viewed 30 March 2020, .
    • MLA:
      Shun Lyu, et al. “Effects of Angelicae Pubescentis and Loranthi Decotion on Repairing Knee Joint Cartilages in Rats.” Journal of Orthopaedic Surgery & Research, vol. 12, Dec. 2017, pp. 1–7. EBSCOhost, doi:10.1186/s13018-017-0679-8.
    • Chicago/Turabian: Humanities:
      Shun Lyu, Bin Ji, Wenwu Gao, Xianqi Chen, Xiaotao Xie, and Junjie Zhou. “Effects of Angelicae Pubescentis and Loranthi Decotion on Repairing Knee Joint Cartilages in Rats.” Journal of Orthopaedic Surgery & Research 12 (December 12, 2017): 1–7. doi:10.1186/s13018-017-0679-8.
    • Vancouver/ICMJE:
      Shun Lyu, Bin Ji, Wenwu Gao, Xianqi Chen, Xiaotao Xie, Junjie Zhou. Effects of Angelicae Pubescentis and Loranthi Decotion on repairing knee joint cartilages in rats. Journal of Orthopaedic Surgery & Research [Internet]. 2017 Dec 12 [cited 2020 Mar 30];12:1–7. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=126824931&custid=s8280428