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Involvement of the JAK- STAT pathway in collagen regulation of decidual NK cells.

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  • معلومة اضافية
    • Author-Supplied Keywords:
      collagen
      decidual NK cells
      JAK‐STAT
      JAK-STAT
      LAIR‐1
      LAIR-1
    • Abstract:
      Problem The mechanisms underlying the regulation of decidual natural killer cells ( dNKs) at the maternal-fetal interface are unclear. Method of study Primary trophoblasts ( TROs), decidual stromal cells ( DSCs), and dNKs were cocultured, and responses to LAIR-2 ( LAIR-1 inhibitor) and P4H sh RNA (collagen inhibitor) were studied. Results Coculture of dNKs with primary TROs/ DSCs resulted in downregulation of Th1 cytokine production by dNKs. These effects were abrogated by LAIR-2 and P4H sh RNA. LAIR-1 binds to SHP-1, which in turn binds to JAK1 and JAK2. Further, the phosphorylation of STAT1/ STAT4 and the expression of the downstream transcription factors T-bet and Helios in dNKs were decreased by collagen treatment and primary TROs/ DSCs coculture. Conclusion The JAK- STAT pathway and its downstream transcription factors T-bet and Helios are involved in the regulation of dNK function by collagen/ LAIR-1 interaction, and this signaling mechanism may contribute to the maintenance of immune tolerance at the maternal-fetal interface. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of American Journal of Reproductive Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1Department of Immunology, Binzhou Medical University, Yantai China
      2Hospital and Institute of Obstetrics & Gynecology, Fudan University, Shanghai China
    • ISSN:
      1046-7408
    • Accession Number:
      10.1111/aji.12769
    • Accession Number:
      126171787
  • Citations
    • ABNT:
      FU, Q. et al. Involvement of the JAK- STAT pathway in collagen regulation of decidual NK cells. American Journal of Reproductive Immunology, [s. l.], v. 78, n. 6, p. n/a-N.PAG, 2017. DOI 10.1111/aji.12769. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=126171787&custid=s8280428. Acesso em: 8 ago. 2020.
    • AMA:
      Fu Q, Sun Y, Tao Y, et al. Involvement of the JAK- STAT pathway in collagen regulation of decidual NK cells. American Journal of Reproductive Immunology. 2017;78(6):n/a-N.PAG. doi:10.1111/aji.12769
    • APA:
      Fu, Q., Sun, Y., Tao, Y., Piao, H., Wang, X., Luan, X., Du, M., & Li, D. (2017). Involvement of the JAK- STAT pathway in collagen regulation of decidual NK cells. American Journal of Reproductive Immunology, 78(6), n/a-N.PAG. https://doi.org/10.1111/aji.12769
    • Chicago/Turabian: Author-Date:
      Fu, Qiang, Yufei Sun, Yu Tao, Hailan Piao, Xiaoqiu Wang, Xiying Luan, Meirong Du, and Dajin Li. 2017. “Involvement of the JAK- STAT Pathway in Collagen Regulation of Decidual NK Cells.” American Journal of Reproductive Immunology 78 (6): n/a-N.PAG. doi:10.1111/aji.12769.
    • Harvard:
      Fu, Q. et al. (2017) ‘Involvement of the JAK- STAT pathway in collagen regulation of decidual NK cells’, American Journal of Reproductive Immunology, 78(6), p. n/a-N.PAG. doi: 10.1111/aji.12769.
    • Harvard: Australian:
      Fu, Q, Sun, Y, Tao, Y, Piao, H, Wang, X, Luan, X, Du, M & Li, D 2017, ‘Involvement of the JAK- STAT pathway in collagen regulation of decidual NK cells’, American Journal of Reproductive Immunology, vol. 78, no. 6, p. n/a-N.PAG, viewed 8 August 2020, .
    • MLA:
      Fu, Qiang, et al. “Involvement of the JAK- STAT Pathway in Collagen Regulation of Decidual NK Cells.” American Journal of Reproductive Immunology, vol. 78, no. 6, Dec. 2017, p. n/a-N.PAG. EBSCOhost, doi:10.1111/aji.12769.
    • Chicago/Turabian: Humanities:
      Fu, Qiang, Yufei Sun, Yu Tao, Hailan Piao, Xiaoqiu Wang, Xiying Luan, Meirong Du, and Dajin Li. “Involvement of the JAK- STAT Pathway in Collagen Regulation of Decidual NK Cells.” American Journal of Reproductive Immunology 78, no. 6 (December 2017): n/a-N.PAG. doi:10.1111/aji.12769.
    • Vancouver/ICMJE:
      Fu Q, Sun Y, Tao Y, Piao H, Wang X, Luan X, et al. Involvement of the JAK- STAT pathway in collagen regulation of decidual NK cells. American Journal of Reproductive Immunology [Internet]. 2017 Dec [cited 2020 Aug 8];78(6):n/a-N.PAG. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=126171787&custid=s8280428