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No Effect of a Whey Growth Factor Extract during Resistance Training on Strength, Body Composition, or Hypertrophic Gene Expression in Resistance-Trained Young Men.

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  • معلومة اضافية
    • Author-Supplied Keywords:
      FOXO3a
      gene expression
      lean tissue mass
      Nutritional supplement
      P70s6k
    • NAICS/Industry Codes:
      541910 Marketing Research and Public Opinion Polling
    • Abstract:
      Growth factors can be isolated from bovine milk to form a whey growth factor extract (WGFE). This study examined whether WGFE promoted activation of the AKT/mTOR pathway enabling increased lean tissue mass and strength in resistance trained men. Forty six men with >6 months of resistance training (RT) experience performed 12 weeks of RT. Participants consumed 20 g/day of whey protein and were randomised to receive either 1.6 g WGFE/day (WGFE; n = 22) or 1.6 g cellulose/day (control, CONT; n = 24). The primary outcome was leg press one-repetition maximum (LP1-RM) which was assessed at baseline, 6 and 12 weeks. At baseline and 12 weeks body composition was assessed by dual energy x-ray absorptiometry, and muscle protein synthesis and gene expression were assessed (vastus lateralis biopsy) in a sub-sample (WGFE n = 10, CONT n = 10) pre- and 3 hr post-training. RT increased LP1-RM (+34.9%) and lean tissue mass (+2.3%; p < 0.05) with no difference between treatments (p > 0.48, treatment x time). Post-exercise P70s6k phosphorylation increased acutely, FOXO3a phosphorylation was unaltered. There were no differences in kinase signalling or gene expression between treatments. Compared with CONT, WGFE did not result in greater increases in lean tissue mass or strength in experienced resistance trained men. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Journal of Sports Science & Medicine is the property of Hakan Gur, Journal of Sports Science & Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1Alliance for Research in Exercise, Nutrition and Activity (ARENA), Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia
      2Clinical Nutrition Research Centre, University of Newcastle, Callaghan, NSW, Australia
      3Department of Kinesiology and Public Health Education, University of North Dakota, North Dakota, USA
      4Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia
      5Murray Goulburn Co-Operative Ltd, Parkville, Melbourne, Australia
      6Basic and Clinical Myology Laboratory, Department of Physiology, University of Melbourne, Australia
      7Liggins Institute, University of Auckland, Auckland, New Zealand
    • ISSN:
      1303-2968
    • Accession Number:
      124286457
  • Citations
    • ABNT:
      DALE, M. J. et al. No Effect of a Whey Growth Factor Extract during Resistance Training on Strength, Body Composition, or Hypertrophic Gene Expression in Resistance-Trained Young Men. Journal of Sports Science & Medicine, [s. l.], v. 16, n. 2, p. 230–238, 2017. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=124286457&custid=s8280428. Acesso em: 23 out. 2020.
    • AMA:
      Dale MJ, Coates AM, Howe PRC, et al. No Effect of a Whey Growth Factor Extract during Resistance Training on Strength, Body Composition, or Hypertrophic Gene Expression in Resistance-Trained Young Men. Journal of Sports Science & Medicine. 2017;16(2):230-238. Accessed October 23, 2020. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=124286457&custid=s8280428
    • APA:
      Dale, M. J., Coates, A. M., Howe, P. R. C., Tomkinson, G. R., Haren, M. T., Brown, A., Caldow, M., Cameron-Smith, D., & Buckley, J. D. (2017). No Effect of a Whey Growth Factor Extract during Resistance Training on Strength, Body Composition, or Hypertrophic Gene Expression in Resistance-Trained Young Men. Journal of Sports Science & Medicine, 16(2), 230–238.
    • Chicago/Turabian: Author-Date:
      Dale, Michael J., Alison M. Coates, Peter R. C. Howe, Grant R. Tomkinson, Matthew T. Haren, Andrew Brown, Marissa Caldow, David Cameron-Smith, and Jonathan D. Buckley. 2017. “No Effect of a Whey Growth Factor Extract during Resistance Training on Strength, Body Composition, or Hypertrophic Gene Expression in Resistance-Trained Young Men.” Journal of Sports Science & Medicine 16 (2): 230–38. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=124286457&custid=s8280428.
    • Harvard:
      Dale, M. J. et al. (2017) ‘No Effect of a Whey Growth Factor Extract during Resistance Training on Strength, Body Composition, or Hypertrophic Gene Expression in Resistance-Trained Young Men’, Journal of Sports Science & Medicine, 16(2), pp. 230–238. Available at: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=124286457&custid=s8280428 (Accessed: 23 October 2020).
    • Harvard: Australian:
      Dale, MJ, Coates, AM, Howe, PRC, Tomkinson, GR, Haren, MT, Brown, A, Caldow, M, Cameron-Smith, D & Buckley, JD 2017, ‘No Effect of a Whey Growth Factor Extract during Resistance Training on Strength, Body Composition, or Hypertrophic Gene Expression in Resistance-Trained Young Men’, Journal of Sports Science & Medicine, vol. 16, no. 2, pp. 230–238, viewed 23 October 2020, .
    • MLA:
      Dale, Michael J., et al. “No Effect of a Whey Growth Factor Extract during Resistance Training on Strength, Body Composition, or Hypertrophic Gene Expression in Resistance-Trained Young Men.” Journal of Sports Science & Medicine, vol. 16, no. 2, June 2017, pp. 230–238. EBSCOhost, search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=124286457&custid=s8280428.
    • Chicago/Turabian: Humanities:
      Dale, Michael J., Alison M. Coates, Peter R. C. Howe, Grant R. Tomkinson, Matthew T. Haren, Andrew Brown, Marissa Caldow, David Cameron-Smith, and Jonathan D. Buckley. “No Effect of a Whey Growth Factor Extract during Resistance Training on Strength, Body Composition, or Hypertrophic Gene Expression in Resistance-Trained Young Men.” Journal of Sports Science & Medicine 16, no. 2 (June 2017): 230–38. http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=124286457&custid=s8280428.
    • Vancouver/ICMJE:
      Dale MJ, Coates AM, Howe PRC, Tomkinson GR, Haren MT, Brown A, et al. No Effect of a Whey Growth Factor Extract during Resistance Training on Strength, Body Composition, or Hypertrophic Gene Expression in Resistance-Trained Young Men. Journal of Sports Science & Medicine [Internet]. 2017 Jun [cited 2020 Oct 23];16(2):230–8. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=124286457&custid=s8280428