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Conditional Survival Analysis Demonstrates that Recurrence Risk of Surgically Treated Hepatocellular Carcinoma Evolves with Time.

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  • معلومة اضافية
    • Author-Supplied Keywords:
      Conditional survival
      Hepatectomy
      Survival analysis
      Tumor recurrence
    • Abstract:
      Objective: The study aim was to investigate long-term change in tumor recurrence risk in patients with hepatocellular carcinoma (HCC) after hepatic resection. Recurrence probability over time was estimated by conditional survival (CS) analysis.Patients and Methods: Early-stage HCC patients with hepatic resection were selected for inclusion from our surgery database. Variables predictive of tumor recurrence were identified by univariate and multivariate analyses. Five-year recurrence-free CS probability was calculated for all patients and for risk groups stratified by independent predictors.Results: In this series of 436 patients, tumor size >5 cm, microvascular invasion, positive resection margin, liver cirrhosis, and a indocyanine green retention ratio at 15 min (ICG-R15) >20% were independently predictive of tumor recurrence. The estimated 5-year recurrence-free CS probability improved with each additional year of recurrence-free survival, and the improvement was significantly greater in the high-risk than in the low- or intermediate-risk groups.Conclusion: CS provides added value during follow-up of early-stage HCC patients treated by surgical resection. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Journal of Gastrointestinal Surgery is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1Department of Surgery , Ajou University School of Medicine , 164 World cup-ro, Yeongtong-gu Suwon 16499 South Korea
      2Division of SMEs Innovation, Supercomputing Modeling and Simulation Center, Department of Supercomputing M&S Technology Development , Korea Institute of Science and Technology Information , Daejeon South Korea
      3Department of Surgery , Catholic Kwandong University International St. Mary's Hospital , Incheon South Korea
      4Graduate School of Public Health , Ajou University , Suwon South Korea
      5Department of Surgery, Ajou University School of Medicine, 164 World cup-ro, Yeongtong-gu, Suwon, 16499, South Korea
      6Department of Surgery, Catholic Kwandong University International St. Mary's Hospital, Incheon, South Korea
      7Graduate School of Public Health, Ajou University, Suwon, South Korea
    • ISSN:
      1091-255X
    • Accession Number:
      10.1007/s11605-017-3437-7
    • Accession Number:
      124215564
  • Citations
    • ABNT:
      PARK, Y. et al. Conditional Survival Analysis Demonstrates that Recurrence Risk of Surgically Treated Hepatocellular Carcinoma Evolves with Time. Journal of Gastrointestinal Surgery, [s. l.], v. 21, n. 8, p. 1237–1244, 2017. DOI 10.1007/s11605-017-3437-7. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=124215564&custid=s8280428. Acesso em: 23 fev. 2020.
    • AMA:
      Park Y, Song S, Kim B-W, et al. Conditional Survival Analysis Demonstrates that Recurrence Risk of Surgically Treated Hepatocellular Carcinoma Evolves with Time. Journal of Gastrointestinal Surgery. 2017;21(8):1237-1244. doi:10.1007/s11605-017-3437-7.
    • APA:
      Park, Y., Song, S., Kim, B.-W., Park, S.-K., Lee, J. I., Lim, S., Wang, H.-J., Park, Y. K., Song, S. K., & Lim, S. S. (2017). Conditional Survival Analysis Demonstrates that Recurrence Risk of Surgically Treated Hepatocellular Carcinoma Evolves with Time. Journal of Gastrointestinal Surgery, 21(8), 1237–1244. https://doi.org/10.1007/s11605-017-3437-7
    • Chicago/Turabian: Author-Date:
      Park, Yong, Sung Song, Bong-Wan Kim, Seung-Keun Park, Jong In Lee, Seung Lim, Hee-Jung Wang, Yong Keun Park, Sung Kyu Song, and Seung Su Lim. 2017. “Conditional Survival Analysis Demonstrates That Recurrence Risk of Surgically Treated Hepatocellular Carcinoma Evolves with Time.” Journal of Gastrointestinal Surgery 21 (8): 1237–44. doi:10.1007/s11605-017-3437-7.
    • Harvard:
      Park, Y. et al. (2017) ‘Conditional Survival Analysis Demonstrates that Recurrence Risk of Surgically Treated Hepatocellular Carcinoma Evolves with Time’, Journal of Gastrointestinal Surgery, 21(8), pp. 1237–1244. doi: 10.1007/s11605-017-3437-7.
    • Harvard: Australian:
      Park, Y, Song, S, Kim, B-W, Park, S-K, Lee, JI, Lim, S, Wang, H-J, Park, YK, Song, SK & Lim, SS 2017, ‘Conditional Survival Analysis Demonstrates that Recurrence Risk of Surgically Treated Hepatocellular Carcinoma Evolves with Time’, Journal of Gastrointestinal Surgery, vol. 21, no. 8, pp. 1237–1244, viewed 23 February 2020, .
    • MLA:
      Park, Yong, et al. “Conditional Survival Analysis Demonstrates That Recurrence Risk of Surgically Treated Hepatocellular Carcinoma Evolves with Time.” Journal of Gastrointestinal Surgery, vol. 21, no. 8, Aug. 2017, pp. 1237–1244. EBSCOhost, doi:10.1007/s11605-017-3437-7.
    • Chicago/Turabian: Humanities:
      Park, Yong, Sung Song, Bong-Wan Kim, Seung-Keun Park, Jong In Lee, Seung Lim, Hee-Jung Wang, Yong Keun Park, Sung Kyu Song, and Seung Su Lim. “Conditional Survival Analysis Demonstrates That Recurrence Risk of Surgically Treated Hepatocellular Carcinoma Evolves with Time.” Journal of Gastrointestinal Surgery 21, no. 8 (August 2017): 1237–44. doi:10.1007/s11605-017-3437-7.
    • Vancouver/ICMJE:
      Park Y, Song S, Kim B-W, Park S-K, Lee JI, Lim S, et al. Conditional Survival Analysis Demonstrates that Recurrence Risk of Surgically Treated Hepatocellular Carcinoma Evolves with Time. Journal of Gastrointestinal Surgery [Internet]. 2017 Aug [cited 2020 Feb 23];21(8):1237–44. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=124215564&custid=s8280428