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Characterization of the effects of receptor-selective ligands in rats discriminating the novel antipsychotic quetiapine.

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  • معلومة اضافية
    • Author-Supplied Keywords:
      α
      Antipsychotic
      Clozapine
      Drug discrimination
      Muscarinic antagonism
      Prazosin
      Quetiapine
      Rats
      Receptor
      Scopolamine
      Selective ligands
    • NAICS/Industry Codes:
      325410 Pharmaceutical and medicine manufacturing
      112990 All Other Animal Production
    • Abstract:
      Rationale. Drug discrimination studies with clozapine have shown that such assays are of value in analysing the actions of novel antipsychotic agents in vivo. Objectives. To evaluate the role of specific receptors in the discriminative stimulus properties of the novel "atypical" antipsychotic quetiapine. Methods. Rats were trained to discriminate quetiapine at 10 mg/kg and tested with a range of ligands, selective for specific classes of receptor. Results. Full generalization to quetiapine was only seen with quetiapine itself (100%) and with the muscarinic antagonist, scopolamine (87%). Partial generalization was seen with the α[sub 1]-adrenoceptor antagonist prazosin (63%), the presumed preferential dopamine D[sub 3] receptor antagonist PNU 91194A (54%) and the 5-HT/H[sub 1]/M[sub 1] antagonist cyproheptadine (55%). Minimal (<40%) or no (0%) generalization was seen with mepyramine (H[sub 1] antagonist), SCH 23390 (D[sub 1] antagonist), raclopride (D[sub 2/3 ]antagonist), ketanserin and MDL 100,907 (5-HT[sub 2A ] antagonists), ondansetron (5-HT[sub 3] antagonist), SB 242,084 (5-HT[sub 2C] antagonist), 8-OHDPAT (5-HT[sub 1A] agonist) yohimbine (α[sub 2]-adrenoceptor antagonist) and the benzodiazepine, chlordiazepoxide. Conclusions. Together with data from a previous study (Smith and Goudie 2002) in which we observed full generalization to quetiapine with olanzapine, risperidone and clozapine, but not with typical antipsychotics (such as haloperidol) or the novel antipsychotic amisulpride, these data suggest that: i) the discriminative stimulus properties of quetiapine, like those of clozapine, probably reflect a "compound" stimulus which involves several classes of receptor; ii) the quetiapine cue is of value in analysing, and screening for, quetiapine- and clozapine-like agents in vivo; iii) blockade of muscarinic receptors is sufficient, although not necessary, to achieve full generalization to quetiapine; and iv) α[sub 1-]adrenoceptors may be implicated in the quetiapine discriminative stimulus. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1Psychology Department, Eleanor Rathbone Building, Liverpool University, UK
      2Institut de Recherches Servier, Psychopharmacology Department, France
    • ISSN:
      0033-3158
    • Accession Number:
      10.1007/s00213-003-1576-x
    • Accession Number:
      11753428
  • Citations
    • ABNT:
      GOUDIE, A. J.; SMITH, J. A.; MILLAN, M. J. Characterization of the effects of receptor-selective ligands in rats discriminating the novel antipsychotic quetiapine. Psychopharmacology, [s. l.], v. 171, n. 2, p. 212–222, 2004. DOI 10.1007/s00213-003-1576-x. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=11753428&custid=s8280428. Acesso em: 11 ago. 2020.
    • AMA:
      Goudie AJ, Smith JA, Millan MJ. Characterization of the effects of receptor-selective ligands in rats discriminating the novel antipsychotic quetiapine. Psychopharmacology. 2004;171(2):212-222. doi:10.1007/s00213-003-1576-x
    • APA:
      Goudie, A. J., Smith, J. A., & Millan, M. J. (2004). Characterization of the effects of receptor-selective ligands in rats discriminating the novel antipsychotic quetiapine. Psychopharmacology, 171(2), 212–222. https://doi.org/10.1007/s00213-003-1576-x
    • Chicago/Turabian: Author-Date:
      Goudie, Andrew J., Judith A. Smith, and Mark J. Millan. 2004. “Characterization of the Effects of Receptor-Selective Ligands in Rats Discriminating the Novel Antipsychotic Quetiapine.” Psychopharmacology 171 (2): 212–22. doi:10.1007/s00213-003-1576-x.
    • Harvard:
      Goudie, A. J., Smith, J. A. and Millan, M. J. (2004) ‘Characterization of the effects of receptor-selective ligands in rats discriminating the novel antipsychotic quetiapine’, Psychopharmacology, 171(2), pp. 212–222. doi: 10.1007/s00213-003-1576-x.
    • Harvard: Australian:
      Goudie, AJ, Smith, JA & Millan, MJ 2004, ‘Characterization of the effects of receptor-selective ligands in rats discriminating the novel antipsychotic quetiapine’, Psychopharmacology, vol. 171, no. 2, pp. 212–222, viewed 11 August 2020, .
    • MLA:
      Goudie, Andrew J., et al. “Characterization of the Effects of Receptor-Selective Ligands in Rats Discriminating the Novel Antipsychotic Quetiapine.” Psychopharmacology, vol. 171, no. 2, Jan. 2004, pp. 212–222. EBSCOhost, doi:10.1007/s00213-003-1576-x.
    • Chicago/Turabian: Humanities:
      Goudie, Andrew J., Judith A. Smith, and Mark J. Millan. “Characterization of the Effects of Receptor-Selective Ligands in Rats Discriminating the Novel Antipsychotic Quetiapine.” Psychopharmacology 171, no. 2 (January 2004): 212–22. doi:10.1007/s00213-003-1576-x.
    • Vancouver/ICMJE:
      Goudie AJ, Smith JA, Millan MJ. Characterization of the effects of receptor-selective ligands in rats discriminating the novel antipsychotic quetiapine. Psychopharmacology [Internet]. 2004 Jan [cited 2020 Aug 11];171(2):212–22. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=11753428&custid=s8280428