Critical analysis of radioiodination techniques for micro and macro organic molecules.

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  • معلومة اضافية
    • Author-Supplied Keywords:
      Chloramine-T
      Iodogen
      N-halosuccinimides
      Radioiodination
      Radioiodo-desilylation
    • Abstract:
      A variety of radioiodination methods is available in the literature depending upon the nature of organic compound to be labeled, however only few can completely fulfill manufacturing requirements.Ideally a selected method should be one which offers maximum benefits like regioselectivity, minimum reaction steps, minimum reaction time, high radiochemical yield and high specific activity. In this review radioiodination techniques were critically analyzed. Advantages, drawbacks, possible mode of action and special reaction conditions required to get high radiochemical yield were taken into account. The influence of iodine introduction on physicochemical properties, in vivo or in vitro pharmacological properties of pharmaceutical due to increase of lipophilicity were discussed along with examples. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Journal of Radioanalytical & Nuclear Chemistry is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1Department of Chemistry, Faculty of Science, The Islamia University of Bahawalpur, Bahawalpur 63100 Pakistan
    • ISSN:
      0236-5731
    • Accession Number:
      10.1007/s10967-015-4679-z
    • Accession Number:
      116709926
  • Citations
    • ABNT:
      MUSHTAQ, S. et al. Critical analysis of radioiodination techniques for micro and macro organic molecules. Journal of Radioanalytical & Nuclear Chemistry, [s. l.], v. 309, n. 2, p. 859–889, 2016. DOI 10.1007/s10967-015-4679-z. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=116709926&custid=s8280428. Acesso em: 20 fev. 2020.
    • AMA:
      Mushtaq S, Jeon J, Shaheen A, Jang B, Park S. Critical analysis of radioiodination techniques for micro and macro organic molecules. Journal of Radioanalytical & Nuclear Chemistry. 2016;309(2):859-889. doi:10.1007/s10967-015-4679-z.
    • APA:
      Mushtaq, S., Jeon, J., Shaheen, A., Jang, B., & Park, S. (2016). Critical analysis of radioiodination techniques for micro and macro organic molecules. Journal of Radioanalytical & Nuclear Chemistry, 309(2), 859–889. https://doi.org/10.1007/s10967-015-4679-z
    • Chicago/Turabian: Author-Date:
      Mushtaq, Sajid, Jongho Jeon, Aqeela Shaheen, Beom Jang, and Sang Park. 2016. “Critical Analysis of Radioiodination Techniques for Micro and Macro Organic Molecules.” Journal of Radioanalytical & Nuclear Chemistry 309 (2): 859–89. doi:10.1007/s10967-015-4679-z.
    • Harvard:
      Mushtaq, S. et al. (2016) ‘Critical analysis of radioiodination techniques for micro and macro organic molecules’, Journal of Radioanalytical & Nuclear Chemistry, 309(2), pp. 859–889. doi: 10.1007/s10967-015-4679-z.
    • Harvard: Australian:
      Mushtaq, S, Jeon, J, Shaheen, A, Jang, B & Park, S 2016, ‘Critical analysis of radioiodination techniques for micro and macro organic molecules’, Journal of Radioanalytical & Nuclear Chemistry, vol. 309, no. 2, pp. 859–889, viewed 20 February 2020, .
    • MLA:
      Mushtaq, Sajid, et al. “Critical Analysis of Radioiodination Techniques for Micro and Macro Organic Molecules.” Journal of Radioanalytical & Nuclear Chemistry, vol. 309, no. 2, Aug. 2016, pp. 859–889. EBSCOhost, doi:10.1007/s10967-015-4679-z.
    • Chicago/Turabian: Humanities:
      Mushtaq, Sajid, Jongho Jeon, Aqeela Shaheen, Beom Jang, and Sang Park. “Critical Analysis of Radioiodination Techniques for Micro and Macro Organic Molecules.” Journal of Radioanalytical & Nuclear Chemistry 309, no. 2 (August 2016): 859–89. doi:10.1007/s10967-015-4679-z.
    • Vancouver/ICMJE:
      Mushtaq S, Jeon J, Shaheen A, Jang B, Park S. Critical analysis of radioiodination techniques for micro and macro organic molecules. Journal of Radioanalytical & Nuclear Chemistry [Internet]. 2016 Aug [cited 2020 Feb 20];309(2):859–89. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=116709926&custid=s8280428