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Extracellular vesicles — new tool for joint repair and regeneration.

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  • معلومة اضافية
    • Abstract:
      Cell-derived extracellular vesicles (EVs), present in synovial fluid and cartilage extracellular matrix (ECM), are involved in joint development and in the regulation of joint homeostasis. Although the exact function of EVs in these processes remains incompletely defined, the knowledge already acquired in this field suggests a role for these EVs as biomarkers of joint disease, and as a new tool to restore joint homeostasis and enhance articular tissue regeneration. In addition to direct injection of therapeutic EVs into the target site, surface coating of scaffolds and embedding of EVs in hydrogels might also lead to novel therapeutic possibilities. Based on the existing literature of EVs in synovial fluid and articular tissues, and investigation of the molecular factors (including microRNAs) active in joint homeostasis (or during its disturbance), we postulate novel perspectives for the implementation of EVs as a regenerative medicine approach in joint repair. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Nature Reviews Rheumatology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, Netherlands
      2Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 112, 3584 CM, Utrecht, Netherlands
      3Department of Biochemistry & Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 2, 3584 CM, Utrecht, Netherlands
    • ISSN:
      1759-4790
    • Accession Number:
      10.1038/nrrheum.2015.170
    • Accession Number:
      114558285
  • Citations
    • ABNT:
      MALDA, J. et al. Extracellular vesicles — new tool for joint repair and regeneration. Nature Reviews Rheumatology, [s. l.], v. 12, n. 4, p. 243–249, 2016. DOI 10.1038/nrrheum.2015.170. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=114558285&custid=s8280428. Acesso em: 25 maio. 2020.
    • AMA:
      Malda J, Boere J, van de Lest CHA, van Weeren PR, Wauben MHM. Extracellular vesicles — new tool for joint repair and regeneration. Nature Reviews Rheumatology. 2016;12(4):243-249. doi:10.1038/nrrheum.2015.170.
    • APA:
      Malda, J., Boere, J., van de Lest, C. H. A., van Weeren, P. R., & Wauben, M. H. M. (2016). Extracellular vesicles — new tool for joint repair and regeneration. Nature Reviews Rheumatology, 12(4), 243–249. https://doi.org/10.1038/nrrheum.2015.170
    • Chicago/Turabian: Author-Date:
      Malda, Jos, Janneke Boere, Chris H. A. van de Lest, P. René van Weeren, and Marca H. M. Wauben. 2016. “Extracellular Vesicles — New Tool for Joint Repair and Regeneration.” Nature Reviews Rheumatology 12 (4): 243–49. doi:10.1038/nrrheum.2015.170.
    • Harvard:
      Malda, J. et al. (2016) ‘Extracellular vesicles — new tool for joint repair and regeneration’, Nature Reviews Rheumatology, 12(4), pp. 243–249. doi: 10.1038/nrrheum.2015.170.
    • Harvard: Australian:
      Malda, J, Boere, J, van de Lest, CHA, van Weeren, PR & Wauben, MHM 2016, ‘Extracellular vesicles — new tool for joint repair and regeneration’, Nature Reviews Rheumatology, vol. 12, no. 4, pp. 243–249, viewed 25 May 2020, .
    • MLA:
      Malda, Jos, et al. “Extracellular Vesicles — New Tool for Joint Repair and Regeneration.” Nature Reviews Rheumatology, vol. 12, no. 4, Apr. 2016, pp. 243–249. EBSCOhost, doi:10.1038/nrrheum.2015.170.
    • Chicago/Turabian: Humanities:
      Malda, Jos, Janneke Boere, Chris H. A. van de Lest, P. René van Weeren, and Marca H. M. Wauben. “Extracellular Vesicles — New Tool for Joint Repair and Regeneration.” Nature Reviews Rheumatology 12, no. 4 (April 2016): 243–49. doi:10.1038/nrrheum.2015.170.
    • Vancouver/ICMJE:
      Malda J, Boere J, van de Lest CHA, van Weeren PR, Wauben MHM. Extracellular vesicles — new tool for joint repair and regeneration. Nature Reviews Rheumatology [Internet]. 2016 Apr [cited 2020 May 25];12(4):243–9. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=114558285&custid=s8280428