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Characterization of olanzapine-induced weight gain in rats.

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  • معلومة اضافية
    • NAICS/Industry Codes:
      325410 Pharmaceutical and medicine manufacturing
      112990 All Other Animal Production
    • Abstract:
      Novel antipsychotic drugs (APDs) have enhanced therapeutic actions compared to 'typical' APDs. However, clinical studies indicate that some induce marked weight gain. We attempted to model this effect in female Wistar rats given olanzapine chronically at 4 mg/kg b.i.d (4.5 h between injections). Such rats showed marked weight gain, which was statistically significant after only a single day of treatment, although weight gain increased up to a plateau after 10 days of treatment. Cessation of treatment led to rapid weight loss, which was significant after a single day of withdrawal. The weight gain observed was characterized by marked individual differences. As some clinical reports suggest that novel APD-induced weight gain is most pronounced in patients with the lowest body weight, we examined the relationship between weight gain and baseline body weight. However, we observed no significant relationship between baseline body weight and weight gain. The observation that olanzapine can induce weight gain rapidly in rats, in conjunction with the observation of marked individual differences in weight gain, suggests that patients at risk of developing weight gain might be detectable early in treatment. Furthermore, the finding that weight gain is rapidly reversible suggests that patients at risk of weight gain could be switched to APDs with less pronounced tendencies to induce weight gain. The study of APD-induced weight gain in rodents may provide insights into the nature, causes, and treatments for, novel APD-induced weight gain in the clinic. However, it remains to be determined how closely rodent models mimic the clinical situation and whether the mechanism(s) involved in the weight gain we have observed are the same as those involved in the clinical use of these drugs. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Journal of Psychopharmacology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • ISSN:
      0269-8811
    • Accession Number:
      10.1177/026988110201600402
    • Accession Number:
      10361465
  • Citations
    • ABNT:
      GOUDIE, A. J.; SMITH, J. A.; HALFORD, J. C. G. Characterization of olanzapine-induced weight gain in rats. Journal of Psychopharmacology, [s. l.], v. 16, n. 4, p. 291–296, 2002. DOI 10.1177/026988110201600402. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=10361465&custid=s8280428. Acesso em: 14 ago. 2020.
    • AMA:
      Goudie AJ, Smith JA, Halford JCG. Characterization of olanzapine-induced weight gain in rats. Journal of Psychopharmacology. 2002;16(4):291-296. doi:10.1177/026988110201600402
    • APA:
      Goudie, A. J., Smith, J. A., & Halford, J. C. G. (2002). Characterization of olanzapine-induced weight gain in rats. Journal of Psychopharmacology, 16(4), 291–296. https://doi.org/10.1177/026988110201600402
    • Chicago/Turabian: Author-Date:
      Goudie, Andrew J., Judith A. Smith, and Jason C. G. Halford. 2002. “Characterization of Olanzapine-Induced Weight Gain in Rats.” Journal of Psychopharmacology 16 (4): 291–96. doi:10.1177/026988110201600402.
    • Harvard:
      Goudie, A. J., Smith, J. A. and Halford, J. C. G. (2002) ‘Characterization of olanzapine-induced weight gain in rats’, Journal of Psychopharmacology, 16(4), pp. 291–296. doi: 10.1177/026988110201600402.
    • Harvard: Australian:
      Goudie, AJ, Smith, JA & Halford, JCG 2002, ‘Characterization of olanzapine-induced weight gain in rats’, Journal of Psychopharmacology, vol. 16, no. 4, pp. 291–296, viewed 14 August 2020, .
    • MLA:
      Goudie, Andrew J., et al. “Characterization of Olanzapine-Induced Weight Gain in Rats.” Journal of Psychopharmacology, vol. 16, no. 4, Dec. 2002, pp. 291–296. EBSCOhost, doi:10.1177/026988110201600402.
    • Chicago/Turabian: Humanities:
      Goudie, Andrew J., Judith A. Smith, and Jason C. G. Halford. “Characterization of Olanzapine-Induced Weight Gain in Rats.” Journal of Psychopharmacology 16, no. 4 (December 2002): 291–96. doi:10.1177/026988110201600402.
    • Vancouver/ICMJE:
      Goudie AJ, Smith JA, Halford JCG. Characterization of olanzapine-induced weight gain in rats. Journal of Psychopharmacology [Internet]. 2002 Dec [cited 2020 Aug 14];16(4):291–6. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=10361465&custid=s8280428