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Synthesis, characterization and biological evaluation of Tc-labeled Mitomycin C.

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  • معلومة اضافية
    • Author-Supplied Keywords:
      Biodistribution and scintigraphy
      Electrophoresis
      HPLC
      Mitomycin C
      Quality control
      TcO
    • Abstract:
      Mitomycin-C is used for the treatment of different types of tumours. In present work, a reliable method was developed for radiolabeling of Mitomycin-C with Tc for diagnostic purpose. Tc-Mitomycin-C was obtained with radiochemical yield of 100 % by adding 200 µg Mitomycin-C, 1 mL (15 mCi) of pertechnetate in 25 μg SnCl·2HO at pH 7. Labeling efficiency was determined by paper chromatography and ITLC. The charge on Tc-Mitomycin-C was determined by electrophoresis technique. HPLC analyses were performed for the determination of purity of Mitomycin-C and radiochemical purity of labeled complex. Evaluation of Tc-Mitomycin-C, in vitro stability, biodistribution and scintigraphic images in normal mice were performed. [ABSTRACT FROM AUTHOR]
    • Abstract:
      Copyright of Journal of Radioanalytical & Nuclear Chemistry is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
    • Author Affiliations:
      1Department of Chemistry, Government College University, Faisalabad, Faisalabad 38000 Pakistan
      2Isotope Production Division, Pakistan Institute of Nuclear Science and Technology, Islamabad Pakistan
      3Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Faisalabad Pakistan
      4Pakistan Institute of Engineering and Applied Sciences, Islamabad Pakistan
    • ISSN:
      0236-5731
    • Accession Number:
      10.1007/s10967-014-3743-4
    • Accession Number:
      101091096
  • Citations
    • ABNT:
      BOKHARI, T. et al. Synthesis, characterization and biological evaluation of Tc-labeled Mitomycin C. Journal of Radioanalytical & Nuclear Chemistry, [s. l.], v. 303, n. 3, p. 1779–1784, 2015. DOI 10.1007/s10967-014-3743-4. Disponível em: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=101091096&custid=s8280428. Acesso em: 1 abr. 2020.
    • AMA:
      Bokhari T, Akbar M, Roohi S, Hina S, Sohaib M, Rizvi F. Synthesis, characterization and biological evaluation of Tc-labeled Mitomycin C. Journal of Radioanalytical & Nuclear Chemistry. 2015;303(3):1779-1784. doi:10.1007/s10967-014-3743-4.
    • APA:
      Bokhari, T., Akbar, M., Roohi, S., Hina, S., Sohaib, M., & Rizvi, F. (2015). Synthesis, characterization and biological evaluation of Tc-labeled Mitomycin C. Journal of Radioanalytical & Nuclear Chemistry, 303(3), 1779–1784. https://doi.org/10.1007/s10967-014-3743-4
    • Chicago/Turabian: Author-Date:
      Bokhari, Tanveer, Muhammad Akbar, Samina Roohi, Saira Hina, Muhammad Sohaib, and Faheem Rizvi. 2015. “Synthesis, Characterization and Biological Evaluation of Tc-Labeled Mitomycin C.” Journal of Radioanalytical & Nuclear Chemistry 303 (3): 1779–84. doi:10.1007/s10967-014-3743-4.
    • Harvard:
      Bokhari, T. et al. (2015) ‘Synthesis, characterization and biological evaluation of Tc-labeled Mitomycin C’, Journal of Radioanalytical & Nuclear Chemistry, 303(3), pp. 1779–1784. doi: 10.1007/s10967-014-3743-4.
    • Harvard: Australian:
      Bokhari, T, Akbar, M, Roohi, S, Hina, S, Sohaib, M & Rizvi, F 2015, ‘Synthesis, characterization and biological evaluation of Tc-labeled Mitomycin C’, Journal of Radioanalytical & Nuclear Chemistry, vol. 303, no. 3, pp. 1779–1784, viewed 1 April 2020, .
    • MLA:
      Bokhari, Tanveer, et al. “Synthesis, Characterization and Biological Evaluation of Tc-Labeled Mitomycin C.” Journal of Radioanalytical & Nuclear Chemistry, vol. 303, no. 3, Mar. 2015, pp. 1779–1784. EBSCOhost, doi:10.1007/s10967-014-3743-4.
    • Chicago/Turabian: Humanities:
      Bokhari, Tanveer, Muhammad Akbar, Samina Roohi, Saira Hina, Muhammad Sohaib, and Faheem Rizvi. “Synthesis, Characterization and Biological Evaluation of Tc-Labeled Mitomycin C.” Journal of Radioanalytical & Nuclear Chemistry 303, no. 3 (March 2015): 1779–84. doi:10.1007/s10967-014-3743-4.
    • Vancouver/ICMJE:
      Bokhari T, Akbar M, Roohi S, Hina S, Sohaib M, Rizvi F. Synthesis, characterization and biological evaluation of Tc-labeled Mitomycin C. Journal of Radioanalytical & Nuclear Chemistry [Internet]. 2015 Mar [cited 2020 Apr 1];303(3):1779–84. Available from: http://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=101091096&custid=s8280428